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The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. Zusätzlich bieten wir Ihnen Hemoglobin Alpha, Adult Chain 1 Proteine (122) und Hemoglobin Alpha, Adult Chain 1 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal HBA-A1 Primary Antibody für ChIP, ELISA - ABIN258357
Chen, Mclean, Thomas, Anderson, Sparling: Point mutations in HpuB enable gonococcal HpuA deletion mutants to grow on hemoglobin. in Journal of bacteriology 2001
Show all 10 Pubmed References
Changes in HbA2 (zeige HBa2 Antikörper) and HbF in alpha thalassemia carriers with KLF1 (zeige KLF1 Antikörper) mutation.
A single genetic origin is responsible for the spread and high prevalence of the alpha(0)-thalassemia (SEA (zeige Slc25a1 Antikörper) deletion) in Southeast Asian populations and allow the monitoring of possible maternal contamination at prenatal diagnosis of this important genetic disorder.
In this study, a novel promoter mutation of -72 (T-->A) within the conserved CCAAT box of beta-globin (zeige HBB Antikörper) gene has been identified in heterozygous state. The proband and his two relatives carrying the same mutation showed almost normal mean corpuscular volume (MCV) and mean corpuscular hemoglobin (zeige HBB Antikörper) (MCH (zeige PMCH Antikörper)) level and slightly elevated HbA2 (zeige HBa2 Antikörper).
Carriers of Hb Nanning are asymptomatic and could be missed by screening based on MCV and MCH (zeige PMCH Antikörper) cutoffs of <80.0 fL and <27.0 pg, respectively. Both carriers of the mutation in the study have MCV and MCH (zeige PMCH Antikörper) values that are 2 standard deviations (SDs (zeige SDS Antikörper)) below normal, as would be predicted for an alpha+-thal.
Data indicate that binding of hemoblobin (Hb) to glycoprotein1balpha (GP1balpha) induced platelet activation plays a crucial role in thrombus formation on immobilized von Willebrand factor (VWF (zeige VWF Antikörper)) or type I collagen under shear stresses.
Hb Adana mutation was preferentially present in the alpha2-globin genes in Malays compared to the other ethnicities in Malaysia.
Seven novel nondeletional alpha-thalassemia mutations localized on the alpha2-globin gene in the heterozygous state were identified
Gene frequency for HBA2 (zeige HBa2 Antikörper):c.301-24delGinsCTCGGCCC carriers among the Chinese population in Guangxi.
Hemoglobin Constant Spring mutation in Southeast Asians with thalassemia.
We report herein for the first time the description of HbA2 (zeige HBa2 Antikörper)' in the Tunisian population.
both Ciprofloxacin and enrofloxacin could lead to the conformational and microenvironmental changes of bovine hemoglobin.
Determination of a representative formal redox potentials of the Fe(II)/Fe(III) redox couple cyanhaemoglobin/cyanmethaemoglobin and the myoglobin (zeige MB Antikörper)/metmyoglobin , at pH=7 and related to the state in solution, was the objective of this work.
Data indicate that on incubating hemoglobin with glyoxal for 0-20 days, advanced glycation end products (AGEs) were detected on day 20.
Residues 33-61a of hemoglobin alpha-chain from cattle tick gut (zeige GUSB Antikörper) exhibit nonconventional conformation for an antimicrobial peptide (zeige CAMP Antikörper), bound to sodium dodecyl sulfate micelles. The peptide is able to disrupt the bacterial membrane of Micrococcus luteus A270.
identify a novel sequence on Hb alpha that is important for Hb alpha/eNOS (zeige NOS3 Antikörper) complex formation and is critical for nitric oxide signaling at myoendothelial junctions
The human locus establishes prominent sites of Polycomb (zeige CBX2 Antikörper) complex recruitment in pluripotent stem cells, whereas the corresponding mouse locus does not.
The objective of this study was to test whether amino acid differences among triplicated alpha-globin paralogs are attributable to a relaxation of purifying selection or to a history of positive selection.
It is suggested that the higher expression of hemoglobin (zeige HBB Antikörper) alpha1 in the brain may be associated with ECM (zeige MMRN1 Antikörper) and could be a source of excess heme, a molecule that is considered to trigger the pathogenesis of cerebral malaria.
These data suggest that CP2b (zeige CYP27B1 Antikörper) potentiate erythroid cell-specific alpha-globin expression by recruiting CP2c into the nucleus.
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin\; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1\; some nondeletion alpha thalassemias have also been reported.
, globin, alpha 1
, hemoglobin alpha chain
, hemoglobin subunit alpha
, alpha globin
, alpha-2 globin
, alpha 1 globin
, alpha globin 1
, haemaglobin alpha 1
, Hemoglobin alpha chain