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The protein encoded by H19 is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide.
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Human H19 ELISA Kit für Sandwich ELISA - ABIN416970
Awojoodu, Keegan, Lane, Zhang, Lynch, Platt, Botchwey: Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD. in Blood 2014
Through genetic analysis it was determined that genetic variants in SMPD1 increase the risk of Parkinson's Disease in the Chinese Han population.
Enzyme activities (acid alpha-glucosidase (GAA), galactocerebrosidase (GALC (zeige GALC ELISA Kits)), glucocerebrosidase (GBA (zeige GBA ELISA Kits)), alpha-galactosidase A (GLA (zeige GLA ELISA Kits)), alpha-iduronidase (IDUA (zeige IDUA ELISA Kits)) and sphingomyeline phosphodiesterase-1 (SMPD-1 (zeige SMPD1 ELISA Kits))) were measured on ~43,000 de-identified dried blood spot (DBS (zeige MCF2L ELISA Kits)) punches, and screen positive samples were submitted for DNA sequencing to obtain genotype confirmation of disease risk
This study shows that the ASM (zeige SMPD1 ELISA Kits) alternative splicing pattern could be a biological target with diagnostic relevance and could serve as a novel biomarker for Major depressive disorder
stress-induced activation of p38 MAPK (zeige MAPK14 ELISA Kits) and apoptosis in endothelial cells and established the link between the acid sphingomyelinase (zeige SMPD1 ELISA Kits)/ceramide and p38 MAPK (zeige MAPK14 ELISA Kits) pathways.
Elevated acid sphingomyelinase (ASM (zeige SMPD1 ELISA Kits)) activity in the lung tumor environment and blood serum of patients with non-small cell lung cancer (NSCLC).
this is the largest study on mutation analysis of patients with ASM (zeige SMPD1 ELISA Kits)-deficient Niemann-Pick disease reported in literature and also the first study on the SMPD1 (zeige SMPD1 ELISA Kits) gene mutation spectrum in India.
ASM (zeige SMPD1 ELISA Kits) and ceramides, together with STX6 (zeige STX6 ELISA Kits) and cholesterol, constitute a new regulatory mechanism for the exit of Met from the Golgi during its biosynthetic route.
the p.Ala359Asp mutation causes structural alterations in the hydrophobic environment where ASM (zeige SMPD1 ELISA Kits) is located, decreasing its enzymatic activity
Airway cells with lower SMPD1 (zeige SMPD1 ELISA Kits) activity increases neutrophil chemotaxis towards them.
The results identify acid sphingomyelinase (zeige SMPD1 ELISA Kits) as a novel target of Lycium Chinense berries to decrease saturated/unsaturated fatty acid sphingomyelin ratio, known to be useful for cell health. Consistent with these data, the berries regulate specifically gene expression to protect cells from apoptosis.
The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified.
, sphingomyelin phosphodiesterase