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Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate.
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These data suggests a novel physiological role for PDE5 (zeige PDE5A ELISA Kits) in restricting the effects of NOS3 (zeige NOS3 ELISA Kits)/sGC (zeige NPR1 ELISA Kits)/PKG (zeige PRKG1 ELISA Kits) signaling pathway to modulating beta-AR stimulated I(Ca), while limiting effects on cardiac contraction.[sGC (zeige NPR1 ELISA Kits)]
Requirement of both alpha-2 and alpha-1 guanylate cyclases for signaling in long-term potentiation (LTP (zeige SCP2 ELISA Kits)) indicates the existence of two distinct nitric oxide/cGMP-mediated pathways, which have to work in concert for expression of LTP (zeige SCP2 ELISA Kits).
The aim of this study was to investigate the role of Gucy1a2 in nitrergic regulation of gastric motility in male and female Gucy1a2 knock-out mice.
The data support a novel regulatory mechanism whereby sGC activity is tuned by distinct domain interactions that either promote or inhibit catalytic activity.
The CO binding affinity of soluble guanylate cyclase alpha 2 subunit is threefold greater than that of human soluble guanylate cyclase alpha 1 subunit.
The sGC alpha 1observed in OVCAR-3 and MDA-MB-468 cancer cells which correlated well with the sGC activity and a marked increase in cGMP levels upon exposure to the combination of a NO donor and a sGC activator.
Soluble guanylyl cyclase (sGC) is the major cellular receptor for the intercellular messenger nitric oxide (NO) and mediates a wide range of physiological effects through elevation of intracellular cGMP levels
No significant changes were found in sGC subunit mRNAs in people with schizophrenia or in controls.
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene.
guanylate cyclase 1, soluble, alpha 2
, guanylate cyclase soluble subunit alpha-2
, guanylate cyclase soluble subunit alpha-2-like
, soluble guanylyl cyclase alpha2 subunit