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The protein encoded by GNL3L appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Zusätzlich bieten wir Ihnen GNL3L Antikörper (65) und GNL3L Kits (5) und viele weitere Produktgruppen zu diesem Protein an.
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GNL3L-LDOC1 (zeige LDOC1 Proteine) interplay regulates cell proliferation through the modulation of NF-kappaB (zeige NFKB1 Proteine) pathway during tumorigenesis.
the present study provides evidence that GNL3L is exported from the nucleus in CRM1 (zeige XPO1 Proteine) dependent manner and the nuclear localization of GNL3L is important to promote 'S' phase progression during cell proliferation.
GNL3L depletion impairs ribosome production without inducing appreciable DNA damage. During evolution, GNL3L retained the role of the ancestral gene in ribosome biosynthesis, whereas the paralogous nucleostemin (zeige E2IG3 Proteine) acquired a novel genome-protective function.
differences in the relative nucleostemin (zeige E2IG3 Proteine) protein and mRNA levels may reflect the degree of proliferation of mesnchymal stem cells and can be used to characterize in vitro expansion capabilities
GNL3L bound MDM2 (zeige MDM2 Proteine) in vivo, stabilizing MDM2 (zeige MDM2 Proteine) and preventing its ubiquitylation. GNL3L depletion upregulated specific p53 (zeige TP53 Proteine) targets (Bax (zeige BAX Proteine), 14-3-3sigma and p21 (zeige CDKN1A Proteine)).
analysis uncovers an important role for Grn1p/GNL3L within this unique group of nucleolar GTPases
GNL3L is composed of distinct modules, each of which plays a specific role in molecular interactions for its nucleolar retention and subsequent function(s) within the nucleolus
work reveals a novel mechanism that negatively regulates the transcriptional function of ERRgamma (estrogen-related receptor (zeige ESRRG Proteine))by GNL3L through coactivator competition.
GNL3L mediates the mitotic increase of TRF1 (zeige TERF1 Proteine) protein and promotes the metaphase-to-anaphase transition.
The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene.
guanine nucleotide-binding protein-like 3-like protein
, guanine nucleotide binding protein-like 3 (nucleolar)-like
, guanine nucleotide-binding protein-like 3-like protein-like
, novel GTPase