Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Zusätzlich bieten wir Ihnen Granulin Antikörper (160) und Granulin Kits (119) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 43 products:
Human Granulin Protein expressed in Wheat germ - ABIN1355792
Chen, Chang, Deng, Xu, Nguyen, Martens, Cenik, Taylor, Hudson, Chung, Yu, Yu, Herz, Farese, Kukar, Tansey: Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Show all 3 Pubmed References
Findings show that miR (zeige MYLIP Proteine)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (zeige MYLIP Proteine)-145 in zebrafish embryonic development.
the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes
GrnA positively modulates hepatic MET expression both in vivo and in vitro.
mTOR (zeige FRAP1 Proteine) signaling contributes to PGRN-stimulated carcinogenesis of cervical cancer
This study describe a novel GRN, p.(Tyr229*) mutation, resulting in haploinsufficiency of GRN and a severe neuropathologic FTLD phenotype.
This meta-analysis supported the T allele of rs5848 within progranulin, as a risk factor for Alzheimer's Disease.
Our case report further corroborates the notion that, in addition to FTD (zeige FTL Proteine), progranulin may be involved in the neurobiology of bipolar disorder type 1, and suggests to screen patients with late-onset bipolar disorder for GRN mutations.
GRN SNPs likely influence disease course and relapse recovery in multiple sclerosis.
This study revealed no patients presenting with typical clinical PSPS to have evidence of GRN mutations producing TDP-43 (zeige TARDBP Proteine) pathology.
This study reported a novel pathogenic splice site mutation in GRN (c.709-2 A>T) causative for FTD (zeige FTL Proteine) and we show that 1) GRN LoF mutations are a rare cause of FTD (zeige FTL Proteine) in this Italian cohort.
progranulin expression is critical for tumor growth in vivo, in both xenograft and orthotopic tumor models
results revealed an important role of NF-kappaB (zeige NFKB1 Proteine) signalling in PGRN-associated frontotemporal lobar degeneration-DNA-binding protein (zeige UBE2V1 Proteine) 43 and confirm that PGRN can bind to TNF-alpha (zeige TNF Proteine) receptors regulating the expression of WNT5A (zeige WNT5A Proteine), suggesting novel targets for treatment of frontotemporal lobar degeneration-DNA-binding protein (zeige UBE2V1 Proteine) linked to GRN mutations.
These results suggest an important role of Wnt (zeige WNT2 Proteine) activation inducing cell cycle disturbance-mediated neuronal loss in the pathogenesis of PGRN deficiency-linked frontotemporal lobar degeneration with TDP-43 (zeige TARDBP Proteine) protein inclusions.
This study demonstrated that Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice.
The results of this study show that endogenous and recombinant PGRN limit axonal injury and astrogliosis and suggest therapeutic potential of PGRN in traumatic brain injury.
Study demonstrate that PGRN interacts with the lysosomal protease CTSD (zeige CTSD Proteine) and maintains its proper activity in vivo. Therefore, by regulating CTSD (zeige CTSD Proteine) activity, PGRN may modulate protein homeostasis. This could potentially explain the TDP-43 (zeige TARDBP Proteine) aggregation observed in frontotemporal lobar degeneration with GRN mutations.
Findings suggest that elevated PGRN is linked to cognitive deficits of fragile X (zeige FMR1 Proteine) syndrome.
highlight an important role for neuron-derived progranulin in maintaining normal social function.
overexpression of PGRN was also found to increase activity of neprilysin (zeige MME Proteine), a key amyloid beta degrading enzyme. PGRN regulation of neprilysin (zeige MME Proteine) activity could play a major role in the observed alterations in plaque burden
PGRN decrease, resulting from pathogenic mutations, might compromise the trophism of cortical neurons by affecting GluN2B (zeige GRIN2B Proteine)-contaning NMDA receptors
The PGRN is a nonredundant regulator of systemic inflammation via modulating the levels and activity of C/EBPalpha, IL-10, and the ubiquitin-proteasome proteolysis pathway.
Grn and Tmem106b genes have opposite effects on lysosomal enzyme levels, and their interaction determines the extent of neurodegeneration
ADAM15 (zeige ADAM15 Proteine) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
, PC cell-derived growth factor