Granulin Proteine (GRN)

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Zusätzlich bieten wir Ihnen Granulin Antikörper (164) und Granulin Kits (128) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
GRN 2896 P28799
GRN 29143 P23785
GRN 14824  
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Top Granulin Proteine auf antikoerper-online.de

Showing 10 out of 45 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HEK-293 Cells Human Unkonjugiert 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$810.00
Details
HEK-293 Cells Ratte DYKDDDDK Tag 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$765.00
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
HEK-293 Cells Maus DYKDDDDK Tag 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$765.00
Details
HEK-293 Cells Maus Unkonjugiert 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$810.00
Details
HEK-293 Cells Ratte Unkonjugiert 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$810.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Escherichia coli (E. coli) Human His tag,S tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$448.00
Details
Escherichia coli (E. coli) Maus His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$608.00
Details

GRN Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
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Rat (Rattus) , ,
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Mouse (Murine) , , ,
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Am meisten referenzierte Granulin Proteine

  1. Human Granulin Protein expressed in Wheat germ - ABIN1355792 : Chen, Chang, Deng, Xu, Nguyen, Martens, Cenik, Taylor, Hudson, Chung, Yu, Yu, Herz, Farese, Kukar, Tansey: Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 (PubMed)
    Show all 3 Pubmed References

Weitere Proteine zu Granulin (GRN) Interaktionspartnern

Zebrafish Granulin (GRN) Interaktionspartner

  1. The data od this study suggest that Pgrn-a plays a dual role during nervous system development by governing the rate at which progenitors progress through the cell cycle and attracting microglial progenitors into the embryonic brain and retina.

  2. Findings show that miR (zeige MYLIP Proteine)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (zeige MYLIP Proteine)-145 in zebrafish embryonic development.

  3. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  4. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) Interaktionspartner

  1. SNPs in GRN are not related to ankylosing spondylitis susceptibility in a Chinese Han population.

  2. Plasma progranulin levels predict the presence of GRN null mutations independent of proximity to symptoms and brain atrophy.

  3. Serum progranulin may have potential to be used as a biomarker for the differentiation between early-onset pre-eclampsia and late-onset pre-eclampsia.

  4. CHI3L1 (zeige CHI3L1 Proteine) may be a previously unrecognized biomarker for diagnosing Gaucher Diseases (GD) and for evaluating the therapeutic effects of new GD drug.

  5. The increased serum progranulin concentrations were closely related to measures of adiposity, metabolic parameters, inflammatory marker and insulin (zeige INS Proteine) resistance indices, suggesting that progranulin may be an excellent biomarker for obesity in childhood.

  6. This work identifies PGRN as an activator of lysosomal cathepsin D (zeige CTSD Proteine) activity, and suggests that decreased cathepsin D (zeige CTSD Proteine) activity due to loss of PGRN contributes to both FTD (zeige FTL Proteine) and NCL (zeige CLN5 Proteine) pathology in a dose-dependent manner.

  7. MiR (zeige MLXIP Proteine)-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN.

  8. Results provide evidence that progranulin destabilizes sortilin (zeige SORT1 Proteine) via ubiquitination and lysosomal degradation to override the negative modulatory functions of sortilin (zeige SORT1 Proteine) thereby assuring the sustainable pro-tumorigenic actions of progranulin in castration-resistant prostate cancer.

  9. PGRN is a regulator of tumorigenesis because it stimulates cell proliferation, migration, invasion, angiogenesis, malignant transformation, resistance to anticancer drugs, and immune evasion. [review]

  10. PGRN regulated its own expression in a positive feedback loop via the AKT (zeige AKT1 Proteine) and ERK (zeige EPHB2 Proteine) signaling pathways.

Mouse (Murine) Granulin (GRN) Interaktionspartner

  1. CHI3L1 (zeige CHI3L1 Proteine) may be a previously unrecognized biomarker for diagnosing Gaucher Diseases (GD) and for evaluating the therapeutic effects of new GD drug.

  2. this study shows that C5a/C5aR pathway accelerates renal ischemia-reperfusion injury by downregulating PGRN expression

  3. PGRN reduction from knock-in R504X mutation disinhibits Gas6 (zeige GAS6 Proteine) binding to Tyro3 (zeige TYRO3 Proteine), resulting in activation of PKCalpha (zeige PKCa Proteine) via PLCgamma, inducing tau phosphorylation at Ser203, mislocalization of tau to dendritic spines, and spine loss

  4. PGRN haploinsufficiency may decrease accumulation of Abeta (zeige APP Proteine).

  5. that mutations resulting in progranulin is processed in the lysosome through the actions of cathepsins

  6. Results from conditional progranulin-knockout mice that lack progranulin in nestin (zeige NES Proteine)-expressing cells (Nes (zeige NES Proteine)-cKO mice), which include most neurons as well as astrocytes, suggest that increased lipofuscinosis and gliosis in Grn-null animals are not caused by intrinsic progranulin deficiency in neurons, and that microglia-derived progranulin may be sufficient to maintain neuronal health and homeostasis in the brain.

  7. PGRN deficiency exacerbates neuroinflammatory responses related to activated microglia in aged animals, while PGRN may not counteract the decline of hippocampal neurogenesis with age.

  8. PGRN is involved in lysosomal homeostasis and lipid metabolism.

  9. findings suggest that PGRN deficiency leads to excessive NF-kappaB (zeige NFKB1 Proteine) activation in microglia and elevated TNFalpha (zeige TNF Proteine) signaling, which in turn lead to hyperexcitability of medium spiny neurons and obsessive-compulsive behavior-like behavior.

  10. PGRN plays a protecting role in hippocampal neurogenesis.

Guinea Pig Granulin (GRN) Interaktionspartner

  1. ADAM15 (zeige ADAM15 Proteine) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) Protein Überblick

Protein Überblick

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Genbezeichner und Symbole assoziert mit Granulin Proteine (GRN)

  • granulin precursor (GRN)
  • granulin a (grna)
  • Granulins (grn)
  • granulin L homeolog (grn.L)
  • granulin (granulin)
  • granulin (ORF1 granulin)
  • granulin precursor (Grn)
  • granulin (Grn)
  • acrogranin Protein
  • CLN11 Protein
  • DKFZp459H066 Protein
  • epithelin Protein
  • GEP Protein
  • GP88 Protein
  • grn Protein
  • MGC53354 Protein
  • PCDGF Protein
  • PEPI Protein
  • PGRN Protein
  • wu:fb11g12 Protein
  • wu:fj18f05 Protein

Bezeichner auf Proteinebene für Granulin Proteine (GRN)

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPEZIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
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