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Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Zusätzlich bieten wir Ihnen Granulin Antikörper (164) und Granulin Kits (128) und viele weitere Produktgruppen zu diesem Protein an.
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Human Granulin Protein expressed in Wheat germ - ABIN1355792
Chen, Chang, Deng, Xu, Nguyen, Martens, Cenik, Taylor, Hudson, Chung, Yu, Yu, Herz, Farese, Kukar, Tansey: Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
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The data od this study suggest that Pgrn-a plays a dual role during nervous system development by governing the rate at which progenitors progress through the cell cycle and attracting microglial progenitors into the embryonic brain and retina.
Findings show that miR (zeige MYLIP Proteine)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (zeige MYLIP Proteine)-145 in zebrafish embryonic development.
the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes
GrnA positively modulates hepatic MET expression both in vivo and in vitro.
The increased serum progranulin concentrations were closely related to measures of adiposity, metabolic parameters, inflammatory marker and insulin (zeige INS Proteine) resistance indices, suggesting that progranulin may be an excellent biomarker for obesity in childhood.
This work identifies PGRN as an activator of lysosomal cathepsin D (zeige CTSD Proteine) activity, and suggests that decreased cathepsin D (zeige CTSD Proteine) activity due to loss of PGRN contributes to both FTD (zeige FTL Proteine) and NCL (zeige CLN5 Proteine) pathology in a dose-dependent manner.
MiR (zeige MLXIP Proteine)-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN.
Results provide evidence that progranulin destabilizes sortilin (zeige SORT1 Proteine) via ubiquitination and lysosomal degradation to override the negative modulatory functions of sortilin (zeige SORT1 Proteine) thereby assuring the sustainable pro-tumorigenic actions of progranulin in castration-resistant prostate cancer.
PGRN is a regulator of tumorigenesis because it stimulates cell proliferation, migration, invasion, angiogenesis, malignant transformation, resistance to anticancer drugs, and immune evasion. [review]
PGRN regulated its own expression in a positive feedback loop via the AKT (zeige AKT1 Proteine) and ERK (zeige EPHB2 Proteine) signaling pathways.
PGRN is involved in lysosomal homeostasis and lipid metabolism.
High serum GP88 concentrations are associated with poor prognosis in patients with DLBCL
This study showed that endogenous levels of multiple GRNs are haploinsufficient in FTD (zeige FTL Proteine)-GRN patient fibroblasts and frontal cortex, mirroring full-length PGRN.
HSPA5 (GRP78 (zeige HSPA5 Proteine)) and GEP were identified to interact. Clinical analysis showed that expression of GRP78 (zeige HSPA5 Proteine) was up-regulated in hepatocellular carcinoma tumor and correlated with GEP expression.
this study shows that C5a/C5aR pathway accelerates renal ischemia-reperfusion injury by downregulating PGRN expression
PGRN reduction from knock-in R504X mutation disinhibits Gas6 (zeige GAS6 Proteine) binding to Tyro3 (zeige TYRO3 Proteine), resulting in activation of PKCalpha (zeige PKCa Proteine) via PLCgamma, inducing tau phosphorylation at Ser203, mislocalization of tau to dendritic spines, and spine loss
PGRN haploinsufficiency may decrease accumulation of Abeta (zeige APP Proteine).
that mutations resulting in progranulin is processed in the lysosome through the actions of cathepsins
Results from conditional progranulin-knockout mice that lack progranulin in nestin (zeige NES Proteine)-expressing cells (Nes (zeige NES Proteine)-cKO mice), which include most neurons as well as astrocytes, suggest that increased lipofuscinosis and gliosis in Grn-null animals are not caused by intrinsic progranulin deficiency in neurons, and that microglia-derived progranulin may be sufficient to maintain neuronal health and homeostasis in the brain.
PGRN deficiency exacerbates neuroinflammatory responses related to activated microglia in aged animals, while PGRN may not counteract the decline of hippocampal neurogenesis with age.
findings suggest that PGRN deficiency leads to excessive NF-kappaB (zeige NFKB1 Proteine) activation in microglia and elevated TNFalpha (zeige TNF Proteine) signaling, which in turn lead to hyperexcitability of medium spiny neurons and obsessive-compulsive behavior-like behavior.
PGRN plays a protecting role in hippocampal neurogenesis.
This study ascertained that PGRN expression in airway epithelial cells inhibits CS-induced apoptosis, presumably through regulation of the ER stress response and MAPK (zeige MAPK1 Proteine) activation.
ADAM15 (zeige ADAM15 Proteine) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
, PC cell-derived growth factor