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GGA2 encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. Zusätzlich bieten wir Ihnen Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 2 Proteine (4) und und viele weitere Produktgruppen zu diesem Protein an.
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GGA2 binds to the internal DXXLL motif of the LRP9 (zeige LRP10 Antikörper)
PI4KIIIbeta (zeige PI4KB Antikörper) interaction with the VHS domain of GGA2 affected PI4KIIIbeta (zeige PI4KB Antikörper) localization.
full length alpha2B (zeige ADRA2B Antikörper)-AR associated with GGA2 but not GGA1 (zeige GGA1 Antikörper), its third intracellular loop was found to directly interact with both GGA1 (zeige GGA1 Antikörper) and GGA2. More interestingly, further mapping of interaction domains showed that the GGA1 (zeige GGA1 Antikörper) hinge region and the GGA2 GAE domain bound to multiple subdomains of the loop.
These data indicate that clathrin is required for the function of AP-1 (zeige FOSB Antikörper)- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane.
GGA2 mediates a vital function that cannot be compensated for by GGA1and/or GGA3 (zeige GGA3 Antikörper).
endocytosis and intracellular transport of memapsin 2 (zeige BACE Antikörper), mediated by its cytosolic domain, may involve the binding of GGA1 (zeige GGA1 Antikörper) and GGA2
Results demonstrate that cargo proteins contribute to the recruitment of GGA2 onto membranes and to the formation of GGA-positive clathrin-coated vesicles.
p56 (zeige IFIT1 Antikörper) tightly cooperates with the GGAs in the sorting of cathepsin D (zeige CTSD Antikörper) to lysosomes, probably by enabling the movement of GGA-containing transport carriers.
GGA2 is recruited to the trans-Golgi network independently of the other Golgi-localized, gamma-ear-containing, ARF-binding proteins and is required for the efficient sorting of lysosomal enzymes
GGA overexpression causes various sorting defects as measured by recycling of CD-MPR, internalization of transferrin receptor, and the subcellular localization of proteins like Tsg101, ubiquitin, and Hrs.
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.
ADP-ribosylation factor-binding protein GGA2
, gamma-adaptin-related protein 2
, golgi-localized, gamma ear-containing, ARF-binding protein 2
, VHS domain and ear domain of gamma-adaptin
, VHS domain and ear domain-containing protein
, golgi associated, gamma adaptin ear containing, ARF binding protein 2