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Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. Zusätzlich bieten wir Ihnen Glycoprotein Ib (Platelet), alpha Polypeptide Antikörper (204) und Glycoprotein Ib (Platelet), alpha Polypeptide Proteine (15) und viele weitere Produktgruppen zu diesem Protein an.
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both the gpIb-VWF (zeige VWF ELISA Kits) interaction and the integrin alpha(2 (zeige ITGA2 ELISA Kits))beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II (zeige GSTA3 ELISA Kits))beta(1) makes a greater contribution to adhesion to type I collagen because less VWF (zeige VWF ELISA Kits) is bound
this study shows that atheroma formation is inhibited in GPIba-deficient mice on atherosclerosis-prone background
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha-binding and heparin-binding site of thrombin (zeige F2 ELISA Kits)
Thrombin (zeige F2 ELISA Kits) cleavage of platelet PAR4 (zeige F2RL3 ELISA Kits) promotes leukocyte recruitment to sites of vascular injury. This process is negatively regulated by GPIbalpha.
GPIbalpha-mediated interactions between platelets and endothelial cells, as well as leukocytes, support innate immune cell recruitment and promote arteriogenesis-establishing platelets as critical players in this process.
Atherosclerosis reduction in mice lacking GPIbalpha may not result from the defective GPIbalpha-ligand binding, but more likely is a consequence of functional defects of GPIbalpha-/- platelets and reduced blood platelet counts.
Data suggest that targeting platelet receptor glycoprotein Ibalpha (GPIbalpha)-von Willebrand factor VWF (zeige VWF ELISA Kits)-A1 binding interface may offer a therapeutic approach to reducing platelet-driven thrombosis.
Following endothelial damage, platelet cross-linking during closure of the vessel lumen is mediated by GPIbalpha-VWF (zeige VWF ELISA Kits) interactions.
Platelet IKKbeta (zeige IKBKB ELISA Kits) deficiency increases the formation of injury-induced arterial neointimal tissue via delayed glycoprotein Ibalpha shedding.
these data demonstrate that coordinated expression of GPIbalpha and filamin (zeige FLNA ELISA Kits) is required for efficient trafficking of either protein to the cell surface, and for production of normal-sized platelets.
Desialylation of platelet VWFR therefore triggers platelet clearance and primes GPIbalpha and GPV (zeige GP5 ELISA Kits) for MP-dependent cleavage.
analysis of an artificial botrocetin that can inhibit the VWF (zeige VWF ELISA Kits)-GPIb interaction
Loss of the platelet surface receptors GPIbalpha and GPVI in heart failure, CF-VAD and ECMO patients may contribute to ablated platelet adhesion/activation, and limit thrombus formation under high/pathologic shear conditions
Very low birth weight preterm neonates have increased numbers of platelets interacting with von Willebrand Factor (zeige VWF ELISA Kits), and increased GPIbalpha expression on the platelet surface
Data suggest that an aspartate at position 1261 is the most critical residue of VWF (zeige VWF ELISA Kits) N-terminal linker for inhibiting binding of VWF (zeige VWF ELISA Kits) A1 domain to GP1BA on platelets in a model simulating blood flow velocity; network of salt bridges between Asp1261 and rest of VWF (zeige VWF ELISA Kits) A1 domain lock N-terminal linker in place such that binding to GP1BA is reduced.
Data show that von Willebrand factor (VWF (zeige VWF ELISA Kits)) is first converted from a compact to linear form by flow, and is subsequently activated to bind platelet glycoprotein Ib alpha polypeptide (GPIbalpha) in a tension-dependent manner.
The >30 nm macroglycopeptide separating the two domains of GPIbalpha transmits force on the VWF (zeige VWF ELISA Kits)-GPIbalpha bond (whose lifetime is prolonged by leucine-rich repeat domain unfolding) to the juxtamembrane mechanosensitive domain to enhance its unfolding, resulting in unfolding cooperativity at an optimal force.
Meta-analysis found that glycoprotein Ia (zeige MMRN1 ELISA Kits) C807T T allele or the TT genotype, the Ser (zeige SIGLEC1 ELISA Kits)-allele of HPA-3 and B allele of glycoprotein Ibalpha variable number tandem repeat polymorphisms were associated with increased risk for ischemic stroke.
Our results suggest that the -5CC genotype in Kozak sequence of GPIb-alpha may be associated with a higher risk of developing arterial ischemia of lower limbs in type 2 diabetes mellitus patients.
Specific inhibition of GPIbalpha shedding in the stored platelets improves post-transfusion platelet recovery and hemostatic function, providing clear evidence for GPIbalpha shedding as a cause of platelet clearance.
miR (zeige MLXIP ELISA Kits)-10a and miR10b regulate the expression of human platelet GP1BA and GP1bb (zeige GP1BB ELISA Kits) for normal megakaryopoiesis.
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.
glycoprotein 1b, alpha polypeptide
, platelet glycoprotein Ib alpha chain
, glycoprotein Ib (platelet), alpha polypeptide
, platelet glycoprotein Ib alpha polypeptide
, GP-Ib alpha
, glycoprotein Ibalpha
, antigen CD42b-alpha
, platelet membrane glycoprotein 1b-alpha subunit