Glutamate-Cysteine Ligase, Modifier Subunit (GCLM) ELISA Kits

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. Zusätzlich bieten wir Ihnen GCLM Antikörper (85) und GCLM Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
GCLM 29739 P48508
GCLM 2730 P48507
GCLM 14630 O09172
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Top GCLM ELISA Kits auf antikoerper-online.de

Showing 10 out of 48 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 0.057 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
$700.00
Details
Maus 0.068 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
$720.00
Details
Ratte 0.052 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
$760.00
Details
Schwein 0.094 ng/mL 0.156-10 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
Details
Kaninchen 0.094 ng/mL 0.156-10 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
Details
Huhn 37.5 pg/mL 62.5-4000 pg/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
Details
Affe 0.094 ng/mL 0.156-10 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
Details
Meerschweinchen
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details
Schaf
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details
Ziege
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details

Weitere ELISA Kits für GCLM Interaktionspartner

Human Glutamate-Cysteine Ligase, Modifier Subunit (GCLM) Interaktionspartner

  1. Glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response in THP-1 macrophages is tightly and differentially regulated via GCLC and GCLM subunits of glutamate cysteine ligase.

  2. Two promoter polymorphisms of GCLM (-588C/T) and GCLC (-128T/C) are associated with an increased risk of ischemic heart disease in Kazakhstan population.

  3. High GCLM expression is associated with chemotherapy resistance in breast cancer.

  4. Glutaminolysis is activated in ES2 and OVCAR3, though ES2 exclusively synthesizes amino acids and GSH. ES2 cells are more resistant to carboplatin than OVCAR3 and the abrogation of GSH production by BSO sensitizes ES2 to carboplatin. HNF1beta regulates the expression of GCLC, but not GCLM, and consequently GSH production in ES2

  5. Data suggest gene expression in vascular endothelium is altered by dietary factors; aged garlic extract induces expression of HMOX1 (heme oxygenase-1) and GCLM via activation of NRF2-ARE (nuclear factor erythroid 2-antioxidant response element) signaling.

  6. miR-433 targets both catalytic (GCLc) and regulatory (GCLm) subunits of GCL.

  7. Data suggest expression of hepatocyte GCLC and GCLM can be regulated by dietary component; alpha-lipoic acid, a vitamin B complex nutrient, protects against oxidative stress/cytotoxicity induced by cadmium via restoration of GCLC and GCLM expression.

  8. miR-320a has a role in modulating the induction of HO-1, GCLM and OKL38 by oxidized phospholipids in endothelial cells

  9. This study demonstrated that Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase.

  10. Knockdown of glutamate cysteine ligase catalytic subunit by siRNA causes the gold nanoparticles-induced cytotoxicity in lung cancer cells.

  11. Upregulation of both GCLC and GLCM mRNA levels in response to cysteine deprivation was dependent on new protein synthesis.

  12. Ten of the 17 maternal SNPs and 2 of the 17 fetal SNPs were found within the GCLM gene conotruncal heart defect cases.

  13. TP is expressed at high levels in human GBM tumors and shRNA knockdown of TP in U87 GBM cells results in a significant increase in cellular GCL enzymatic activity

  14. SNPs not associated with self-reported depression

  15. When eicosapentaenoic+docosahexaenoic acid or erythrocyte-mercury were divided into tertiles, GCLM-588 TT genotype individuals showed a lower risk than CC genotype; however, there were few TT carriers and the results were not statistically significant.

  16. GCLM is a functional target gene of the BACH1 transcription factor according to ChIP-seq and knockdown analysis in HEK 293 cells.

  17. Posttranslational modification and regulation of glutamate-cysteine ligase by the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal.

  18. SNPs not associted with schizophrenia in Japanese individuals

  19. The polymorphism of GCLM -588C/T and -23G/T sites were associated with susceptibility to COPD.

  20. To further investigate the role of the GCLM locus in schizophrenia susceptibility, we studied three SNPs and haplotypes in the region of GCLM using Han Chinese case-control samples.

Mouse (Murine) Glutamate-Cysteine Ligase, Modifier Subunit (GCLM) Interaktionspartner

  1. glutathione levels in the skin of Gclm knock-out mice are reduced by 70 %, which is sufficient for wound repair in young mice, but become rate-limiting upon aging

  2. Gclm(-/-) mice have accelerated ovarian aging due to ovarian oxidative stress.

  3. Upregulation of both GCLC and GLCM mRNA levels in response to cysteine deprivation was dependent on new protein synthesis.

  4. In Gclm KO mice, early-life insults inducing oxidative stress are detrimental to immature parvalbumin interneurons and have long-term consequences.

  5. Wild type female mice deficient in GSH due to deletion of Gclm were resistant to increase visceral adiposity and hepatic steatosis caused by exposure to the PAH BaP.

  6. The glutathione synthesis gene Gclm modulates amphiphilic polymer-coated CdSe/ZnS quantum dot-induced lung inflammation in mice.

  7. Anxiety and drug-stimulated locomotor control brain regions are vulnerable to gclm/glutathione deficiencies.

  8. Clinically relevant levels of TGF-beta1 suppresses GCLC and GCLM expression in mouse lung.

  9. Genetic disruption of Gclm results in reduced aortic glutathione content and impaired acetylcholine mediated aortic ring relaxation.

  10. Data suggest that Gclm is not involved in spermatogenesis but is involved in shielding testis/epididymis from oxidative stress; Gclm knockout mice are fertile but more sensitive to transplacental testicular/epididymal toxicity of benzo[a]pyrene.

  11. gclm KO mice showed a potentiated hyperlocomotor response to amphetamine, impaired sensorimotor gating, and altered social behavior compared to WT. These anomalies resemble important aspects of both SZ and the manic component of BP.

  12. This finding indicates that GSH synthesis can mediate DEP-induced lung inflammation and suggests that polymorphisms in Gclm may be an important factor in determining adverse health outcomes in humans following inhalation of particulate matter.

  13. Gclm is involved in the regulation of basal metabolic rate and metabolism of dietary lipid

  14. investigation of roles for maternal Gclm in preimplantation development: Gclm -/- mice (compared to Gclm +/+ littermates) exhibit lower litter size, fewer uterine implantation sites, delayed blastocyst development after in vitro fertilization

  15. GCLM(-/-) mice were susceptible to myocardial I/R injury partly through an increased vulnerability of mitochondria to oxidative damage owing to mitochondrial GSH reduction

  16. primary fibroblasts from knock-out mice disaplay premature senescence

  17. induction in RAW264.7 cells by Nepsilon-(Carboxymethyl)lysine

  18. Glutamate-cysteine ligase catalytic subunit knockout mice are described.

  19. the oxPAPC-inducible expression of heme oxygenase-1, GCLM, and NQO1 is lower in Nrf2-null than wild-type mouse carotid arteries in vivo.

GCLM Antigen-Profil

Beschreibung des Gens

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.

Genbezeichner und Symbole assoziert mit GCLM

  • glutamate-cysteine ligase regulatory subunit (PTRG_09814) Antikörper
  • glutamate cysteine ligase, modifier subunit (Gclm) Antikörper
  • glutamate-cysteine ligase modifier subunit (GCLM) Antikörper
  • glutamate-cysteine ligase, modifier subunit (gclm) Antikörper
  • glutamate-cysteine ligase, modifier subunit L homeolog (gclm.L) Antikörper
  • glutamate-cysteine ligase, modifier subunit (Gclm) Antikörper
  • glutamate-cysteine ligase modifier subunit (Gclm) Antikörper
  • AI649393 Antikörper
  • Gcmc Antikörper
  • GLCLR Antikörper
  • id:ibd3182 Antikörper
  • wu:fi24c07 Antikörper
  • zgc:55903 Antikörper

Bezeichner auf Proteinebene für GCLM

glutamate-cysteine ligase regulatory subunit , GCS light chain , gamma-ECS regulatory subunit , gamma-glutamylcysteine synthetase regulatory subunit , glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory , glutamate--cysteine ligase regulatory subunit , glutamate-cysteine ligase modifier subunit , GSC light chain , glutamate--cysteine ligase modifier subunit , glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD) , glutamate-cysteine ligase modifier subunit delta2 alternative splicing , glutamate-cysteine ligase regulatory protein

GENE ID SPEZIES
6348110 Pyrenophora tritici-repentis Pt-1C-BFP
29739 Rattus norvegicus
100352174 Oryctolagus cuniculus
333974 Danio rerio
380105 Xenopus laevis
424492 Gallus gallus
2730 Homo sapiens
525659 Bos taurus
14630 Mus musculus
100725164 Cavia porcellus
101117899 Ovis aries
100153977 Sus scrofa
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