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Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. Zusätzlich bieten wir Ihnen GCLM Antikörper (107) und GCLM Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.
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Glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response in THP-1 (zeige GLI2 ELISA Kits) macrophages is tightly and differentially regulated via GCLC (zeige GCLC ELISA Kits) and GCLM subunits of glutamate cysteine ligase (zeige GCLC ELISA Kits).
Two promoter polymorphisms of GCLM (-588C/T) and GCLC (zeige GCLC ELISA Kits) (-128T/C) are associated with an increased risk of ischemic heart disease in Kazakhstan population.
High GCLM expression is associated with chemotherapy resistance in breast cancer.
Glutaminolysis is activated in ES2 (zeige DGCR14 ELISA Kits) and OVCAR3, though ES2 (zeige DGCR14 ELISA Kits) exclusively synthesizes amino acids and GSH. ES2 (zeige DGCR14 ELISA Kits) cells are more resistant to carboplatin than OVCAR3 and the abrogation of GSH production by BSO sensitizes ES2 (zeige DGCR14 ELISA Kits) to carboplatin. HNF1beta (zeige HNF1B ELISA Kits) regulates the expression of GCLC (zeige GCLC ELISA Kits), but not GCLM, and consequently GSH production in ES2 (zeige DGCR14 ELISA Kits)
Data suggest gene expression in vascular endothelium is altered by dietary factors; aged garlic extract induces expression of HMOX1 (heme oxygenase-1 (zeige HMOX1 ELISA Kits)) and GCLM via activation of NRF2 (zeige GABPA ELISA Kits)-ARE (nuclear factor erythroid 2-antioxidant response element) signaling.
miR-433 targets both catalytic (GCLc) and regulatory (GCLm) subunits of GCL.
Data suggest expression of hepatocyte GCLC (zeige GCLC ELISA Kits) and GCLM can be regulated by dietary component; alpha-lipoic acid, a vitamin B complex nutrient, protects against oxidative stress/cytotoxicity induced by cadmium via restoration of GCLC (zeige GCLC ELISA Kits) and GCLM expression.
miR (zeige MLXIP ELISA Kits)-320a has a role in modulating the induction of HO-1 (zeige HMOX1 ELISA Kits), GCLM and OKL38 (zeige OSGIN1 ELISA Kits) by oxidized phospholipids in endothelial cells
This study demonstrated that Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase (zeige GCLC ELISA Kits).
Knockdown of glutamate cysteine ligase catalytic subunit (zeige GCLC ELISA Kits) by siRNA causes the gold nanoparticles-induced cytotoxicity in lung cancer cells.
glutathione levels in the skin of Gclm knock-out mice are reduced by 70 %, which is sufficient for wound repair in young mice, but become rate-limiting upon aging
Gclm(-/-) mice have accelerated ovarian aging due to ovarian oxidative stress.
Upregulation of both GCLC (zeige GCLC ELISA Kits) and GLCM mRNA levels in response to cysteine deprivation was dependent on new protein synthesis.
In Gclm KO mice, early-life insults inducing oxidative stress are detrimental to immature parvalbumin (zeige PVALB ELISA Kits) interneurons and have long-term consequences.
Wild type female mice deficient in GSH due to deletion of Gclm were resistant to increase visceral adiposity and hepatic steatosis caused by exposure to the PAH BaP (zeige PHB2 ELISA Kits).
The glutathione synthesis gene Gclm modulates amphiphilic polymer-coated CdSe/ZnS quantum dot-induced lung inflammation in mice.
Anxiety and drug-stimulated locomotor control brain regions are vulnerable to gclm/glutathione deficiencies.
Clinically relevant levels of TGF-beta1 (zeige TGFB1 ELISA Kits) suppresses GCLC (zeige GCLC ELISA Kits) and GCLM expression in mouse lung.
Genetic disruption of Gclm results in reduced aortic glutathione content and impaired acetylcholine mediated aortic ring relaxation.
Data suggest that Gclm is not involved in spermatogenesis but is involved in shielding testis/epididymis from oxidative stress; Gclm knockout mice are fertile but more sensitive to transplacental testicular/epididymal toxicity of benzo[a]pyrene.
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.
glutamate-cysteine ligase regulatory subunit
, GCS light chain
, gamma-ECS regulatory subunit
, gamma-glutamylcysteine synthetase regulatory subunit
, glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory
, glutamate--cysteine ligase regulatory subunit
, glutamate-cysteine ligase modifier subunit
, GSC light chain
, glutamate--cysteine ligase modifier subunit
, glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD)
, glutamate-cysteine ligase modifier subunit delta2 alternative splicing
, glutamate-cysteine ligase regulatory protein