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L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors.
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Human Metabotropic Glutamate Receptor 1 ELISA Kit für Sandwich ELISA - ABIN420429
Bovenschen, Spijkers, Wensink, Schellens, van Domselaar, van Baarle: Elevated granzyme M-expressing lymphocytes during cytomegalovirus latency and reactivation after allogeneic stem cell transplantation. in Clinical immunology (Orlando, Fla.) 2014
Age-dependent increase in metabotropic glutamate (zeige GRIN1 ELISA Kits) receptor type 1 availability in several brain regions may exist predominantly in males.
Missense Mutation in GRM1 gene is associated with Spinocerebellar Ataxia Type 44.
our findings suggest that pharmacological manipulation of mglur1 should be explored as an exciting new approach for the treatment of a variety of human cerebellar ataxias.
a missense variant was found in GRM1 gene, while in the second family, a frameshift alteration was identified in TRMT1, both of which were found to co-segregate with the intellectual disability.
It has the intrinsic ability to form a heteromeric complex with adenosine A1 receptor (zeige ADORA1 ELISA Kits) and mutually modulate signaling.
These data demonstrate that the approaches commonly used to study mGlu1 receptor function and signaling in other systems may be inappropriate for studying mGlu1 receptor-mediated melanoma cell viability.
Our results are likely relevant to human breast cancer, highlighting a putative role of mGluR1 in the pathophysiology of breast cancer and the potential of mGluR1 as a novel therapeutic target.
elevated glutamate (zeige GRIN1 ELISA Kits) secretion and mGluR1 expression play a role in Kaposi's sarcoma associated herpesvirus induced cell proliferation
alpha-actinin-4 (zeige ACTN4 ELISA Kits) is a novel group 1 mGluR (zeige GRM8 ELISA Kits)-interacting partner that orchestrates spine dynamics and morphogenesis in neurons.
Deleterious GRM1 mutations are associated with schizophrenia.
Study shows that blocking of metabotropic glutamate (zeige GRIN1 ELISA Kits) type 5 receptor (mGlu5 (zeige GRM5 ELISA Kits)) reduced the dysregulation of glutamate (zeige GRIN1 ELISA Kits) transmission and improved motor coordination in the metabotropic glutamate (zeige GRIN1 ELISA Kits) type 1 receptor (Grm1crv4) mouse model of cerebellar ataxia SCAR13.
These findings demonstrate that mGlu1 receptors play a key role in excitotoxic degeneration of retinal ganglion cell
this work reveals novel functions of mGlu1 receptors in the bone and indicates that in osteoblasts mGlu1 receptors are necessary for production of normal bone matrix, longitudinal bone growth, and normal skeletal development.
mGluR1 activation at the onset of reperfusion induces cardioprotection and might represent a putative strategy to prevent ischaemia-reperfusion injury.
These findings demonstrate a deleterious positive feedback loop involving elevated intracellular calcium and enhanced mGluR1 function, a mechanism likely to contribute to Purkinje neuron dysfunction and loss in spinocerebellar ataxia type 2.
mouse external globus pallidus astrocytes critically control ambient glutamate (zeige GRIN1 ELISA Kits) level, which in turn gates striatopallidal transmission via the activation of presynaptic metabotropic glutamate (zeige GRIN1 ELISA Kits) receptors.
The results of our study showed that thalamic mGluR1-PLCbeta4 pathway was critical in controlling sleep architecture.
This study confirmed the presence of mGluR1/5 complex by (i) reverse immunoprecipitation using an mGluR1 antibody to pulldown mGluR5 (zeige GRM5 ELISA Kits) from hippocampal tissue.
results demonstrate that mGluR1 is crucial for the visual-experience-dependent maintenance of mature synaptic connectivity in the dorsal Lateral Geniculate Nuc.
These results suggest that impairment of synaptic mGluR (zeige GRM8 ELISA Kits) cascades is one of the important contributing factors to cerebellar ataxia in early and middle stages of spinocerebellar ataxia type 1 (SCA1 (zeige ATXN1 ELISA Kits)) pathology, and that modulation of mGluR (zeige GRM8 ELISA Kits) signalling by baclofen or other clinical interventions may be therapeutic targets to treat SCA1 (zeige ATXN1 ELISA Kits)
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms\; some of which may have distinct functions.
metabotropic glutamate receptor 1
, metabotropic glutamate receptor A
, G protein coupled receptor, family C, group 1, member A
, G protein-coupled receptor, family C, group 1, member A
, G protein coupled receptor family C group 1 member A