anti-Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE) Antikörper

The protein encoded by GNE is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids.

Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Human GNE GNE 10020 Q9Y223
Anti-Maus GNE GNE 50798 Q91WG8
Anti-Ratte GNE GNE 114711 O35826
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top anti-GNE Antikörper auf antikoerper-online.de

Showing 10 out of 69 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert FACS, WB GNE Antibody (C-term) (ABIN651511) western blot analysis in mouse kidney tissue lysates (35 µg/lane). This demonstrates the GNE antibody detected GNE protein (arrow). GNE Antibody (C-term) (ABIN651511) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB GNE Antibody (N-term) (ABIN656219) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue reacted with GNE / GLCNE Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis of GNE / GLCNE Antibody (N-term) in human placenta tissue lysates (35ug/lane). This demonstrates the GNE antibody detected the GNE protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB 100 μL Anmelden zum Anzeigen 16 Days
$181.73
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB   100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Maus Unkonjugiert ELISA, WB Western Blot detection against Immunogen (38.21 KDa) . 50 μL Anmelden zum Anzeigen 11 bis 12 Tage
$305.71
Details
Human Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of various cells, using GNE antibody. Immunohistochemistry of paraffin-embedded mouse brain using GNE antibody at dilution of 1:100 (x40 lens). 100 μL Anmelden zum Anzeigen 16 Days
$334.02
Details
Human Kaninchen Unkonjugiert WB Western Blot analysis of GNE expression in transfected 293T cell line by GNE MaxPab polyclonal antibody.<br><br>Lane 1: GNE transfected lysate(79.30 KDa).<br>Lane 2: Non-transfected lysate.<br> 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$425.71
Details
Human Kaninchen Unkonjugiert WB   100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$903.83
Details
Human Kaninchen Unkonjugiert FACS, ELISA, WB   200 μL Anmelden zum Anzeigen 11 bis 16 Tage
$594.00
Details

Weitere Antikörper gegen GNE Interaktionspartner

Zebrafish Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE) Interaktionspartner

  1. The results demonstrate a critical novel role for gne in embryonic development and particularly in myofiber development, muscle integrity and activity.

Human Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE) Interaktionspartner

  1. Thirty-five different mutations in the GNE gene were recorded in a cohort of GNE-myopathy patients from the Indian subcontinent. p.Val727Met is likely to be a founder mutation of Indian subcontinent.

  2. the interaction between GNE and alpha-actinin 1 (zeige ACTN1 Antikörper) and alpha-actinin 2 (zeige ACTN2 Antikörper) occur at different sites in the alpha-actinin (zeige ACTN1 Antikörper) molecules and that for alpha-actinin 2 (zeige ACTN2 Antikörper) the interaction site is located at the C-terminus of the protein.

  3. the half-life of the M743T variant is two times longer than for the wild-type GNE protein. This study provides that the balance of phosphorylation and O-GlcNAcylation is decisive involved in efficiency and regulation of GNE.

  4. The results of this study widen the spectra of mutations to copy number variations encompassing 5'UTR (zeige UTS2R Antikörper), underscoring the pivotal role of the hGNE1 transcript in GNE myopathy.

  5. the complex crystal structure of the N-terminal epimerase part of human GNE shows a tetramer in which UDP binds to the active site and CMP (zeige MATN1 Antikörper)-Neu5Ac binds to the dimer-dimer interface.

  6. This study confirms that c.2228T>C (p.M743T) is the most prevalent disease-causing variant in the non-Jewish Persian population, but other GNE variants can cause GNE myopathy in this population.

  7. examined the consequences of the mutated GNEM743T enzyme in myoblasts cultures, depicted by the pattern of central signaling proteins of the PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper), BCL2 (zeige BCL2 Antikörper) and ARTS/XIAP (zeige XIAP Antikörper) pathways

  8. Novel GNE mutations were linked to GNE myopathy in patients from mainland China.

  9. GNE is a master regulator of sialic acid synthesis in the vertebrates. (Review)

  10. mutation in UDP-N-acetylglucosamine2-epimerase/N-acetylmannosamine kinase (GNE) affects beta1-integrin-mediated cell adhesion process in GNE mutant cells

Mouse (Murine) Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE) Interaktionspartner

  1. GNE is a master regulator of sialic acid synthesis in the vertebrates. (Review)

  2. Analysis of differential Gne transcript expression of the two splice variants, Gne1 and Gne2.

  3. GNE is strongly involved in cardiac tissue and skeletal muscle early survival and organization.

  4. Our findings suggest that GNE expression is induced when myofibers are damaged or regenerating, and that GNE plays a role in muscle regeneration.

  5. sialic acid biosynthesis is involved in proliferation and expression of GNE

  6. inactivation of the UDP-GlcNAc (zeige B3GNT2 Antikörper) 2-epimerase (zeige RENBP Antikörper) by gene targeting causes early embryonic lethality in mice, thereby emphasizing the fundamental role of this bifunctional enzyme and sialylation during development

  7. compared the amount of membrane-bound sialic acids of wildtype mice with those of heterozygous GNE-deficient mice

  8. Mutations in the Gne enzyme, which encode the rate-limiting enzyme in sialic acid biosynthesis, are causative of distal myopathies with rimmed vacuoles or hereditary inclusion body myopathy.

GNE Antigen-Profil

Protein Überblick

The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit GNE

  • glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE) Antikörper
  • glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (gne) Antikörper
  • glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (Gne) Antikörper
  • 2310066H07Rik Antikörper
  • DMRV Antikörper
  • GLCNE Antikörper
  • GNE Antikörper
  • IBM2 Antikörper
  • MGC145505 Antikörper
  • NM Antikörper
  • Uae1 Antikörper
  • zgc:77657 Antikörper

Bezeichner auf Proteinebene für GNE

UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase , bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase , glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase , bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase-like , N-acylmannosamine kinase , UDP-GlcNAc-2-epimerase/ManAc kinase , UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase , UDP-N-acetylglucosamine-2-epimerase/N- acetylmannosamine kinase

GENE ID SPEZIES
641344 Sus scrofa
393857 Danio rerio
427285 Gallus gallus
465094 Pan troglodytes
481607 Canis lupus familiaris
693525 Macaca mulatta
780185 Xenopus (Silurana) tropicalis
782201 Bos taurus
100171416 Pongo abelii
100340455 Oryctolagus cuniculus
100414213 Callithrix jacchus
100481169 Ailuropoda melanoleuca
100541275 Meleagris gallopavo
100554566 Anolis carolinensis
100589824 Nomascus leucogenys
10020 Homo sapiens
50798 Mus musculus
114711 Rattus norvegicus
100689450 Cricetulus griseus
Haben Sie etwas anderes gesucht?