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GRAP encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. Zusätzlich bieten wir Ihnen GRAP Proteine (5) und GRAP Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal GRAP Primary Antibody für ELISA, WB - ABIN256861
Fathi, Rasouli, Yeganeh, Salekdeh, Baharvand: Efficient differentiation of human embryonic stem cells toward dopaminergic neurons using recombinant LMX1A factor. in Molecular biotechnology 2015
Show all 2 Pubmed References
A compound mutation consisting of a large deletion and a nonsense mutation, which provides a new insight in the mutation type of CTSC (zeige CTSC Antikörper) gene.
CTSC (zeige CTSC Antikörper) gene missense mutation is responsible for Papillo- Lefevre syndrome in a Turkish family.
analysis of fluorescent substrates provides a detailed S' specificity study of cathepsin C (zeige CTSC Antikörper)
Mutation screening of the CTSC (zeige CTSC Antikörper) gene from the two patients revealed the presence of the same homozygous nonsense mutation in Papillon-Lefevre syndrome and Haim-Munk syndromes. Phenotypic variants of the same rare disease caused by mutations of the cathepsin C (CTSC (zeige CTSC Antikörper)) gene.
Neutrophilic Cathepsin C (zeige CTSC Antikörper) Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases.
CTSC (zeige CTSC Antikörper) was associated with albuminuria in type 2 diabetes patients.
Homozygous mutation 901G>A in exon 7 of CTSC (zeige CTSC Antikörper) gene is associated with Papillon-Lefevre syndrome.
Results identify a missense mutation in CTSC (zeige CTSC Antikörper) gene that segregate within a family with Papillon-Lefevre syndrome.
Papillon-Lefevre syndrome cause by homozygous nonsense mutation of cathepsin C (zeige CTSC Antikörper) gene.
CatC (zeige CTSC Antikörper) has a role in the selective tuning of innate and adaptive immune responses, relevant to a chronic immune disease, such as atherosclerosis.
Grb2-related adaptor protein (GRAP) was up-regulated in kidney tubules from diabetic mice, indicating a potential novel role for GRAP in TGF-beta (zeige TGFB1 Antikörper)-induced tubule injury in diabetic kidney disease.
Data suggest that Grap, unlike Grb2 (zeige GRB2 Antikörper), acts as a negative regulator of TCR-stimulated intracellular signaling by downregulating signal relay through the Ras/Erk (zeige EPHB2 Antikörper) pathway.
Results suggest that the GRAP gene might have a role in the pathogenesis of Sjogren's syndrome.
FcgammaRIIB docking site for the SH2 (zeige MYO15 Antikörper) domain-containing adapters Grb2 (zeige GRB2 Antikörper) and Grap
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene.
GRB2-related adapter protein
, growth factor receptor-bound protein 2-related adaptor protein
, cathepsin J
, dipeptidyl peptidase 1
, dipeptidyl peptidase I
, dipeptidyl transferase
, dipeptidyl-peptidase I
, GRB2-related adaptor protein