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GM2A encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Zusätzlich bieten wir Ihnen GM2 Ganglioside Activator Antikörper (155) und GM2 Ganglioside Activator Kits (19) und viele weitere Produktgruppen zu diesem Protein an.
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Review of GM2A mutations causing GM2 (zeige CYB5D2 Proteine) activator protein deficiency and GM2 (zeige CYB5D2 Proteine) gangliosidosis-AB variant.
Studies indicate that sphingolipid activator proteins (SAPs (zeige SKAP2 Proteine)) and anionic lipids are essential stimulators to reach physiological rates of lysosomal sphingolipid degradation.
this study has established the potential role of GM2A in breast cancer progression
Mobilization of membrane lipids by GM2AP was also inhibited in the presence of cholesterol or SM, as revealed by surface plasmon resonance studies
Gene polymorphisms of MD2 (zeige LY96 Proteine) and GM2A were associated with the occurrence or severity of neonatal necrotizing enterocolitis.
In vitro assays with the isolated H1 or H2 homodimers (beta-alpha hybrid construct of beta-hexosaminidase A subunits) confirmed that neither was capable of human GM2AP-dependent hydrolysis of GM2 (zeige CYB5D2 Proteine) ganglioside.
impact of GM2AP on glucose metabolism
Treatment of meniscal explants with IL-1RA (zeige IL1RN Proteine) inhibited the expression of many catabolic genes following a single bout of high dynamic strain.
these results provide novel insights into the physiological functions of GM2AP in obesity.
GM2 (zeige CYB5D2 Proteine) activator protein exerts strong and broad inhibitory effects on the hydrolysis of phospholipids carried out by plant and microbial phospholipases D
The most interesting finding was the association of the GM2-AP with the acrosomal apparatus in early spermatids. A modest to intense staining was observed in some acrosomal granules and acrosomal caps (zeige CAPS Proteine). The GM2-AP seemed to disappear from acrosomal caps (zeige CAPS Proteine) in the later stage of spermatids, in which the nucleus became elongated and condensed.
The trafficking of prosaposin (zeige PSAP Proteine) and GM2 (zeige CYB5D2 Proteine) activator protein to the lysosome in sertoli cells is dependent on sortilin (zeige SORT1 Proteine).
This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants.
GM2 ganglioside activator protein
, ganglioside GM2 activator
, GM2 ganglioside activator
, GM2 activator protein
, cerebroside sulfate activator protein
, shingolipid activator protein 3
, sphingolipid activator protein 3