GDNF Family Receptor alpha 2 (GFRA2) ELISA Kits

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. Zusätzlich bieten wir Ihnen GFRA2 Antikörper (95) und GFRA2 Proteine (17) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
GFRA2 2675 O00451
GFRA2 14586  
Anti-Ratte GFRA2 GFRA2 25136  
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Top GFRA2 ELISA Kits auf antikoerper-online.de

Showing 3 out of 3 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Lieferzeit Preis Details
Human
  96 Tests 26 bis 36 Tage
$899.80
Details
Human
  96 Tests 31 bis 41 Tage
$734.80
Details
Maus
  96 Tests 21 bis 31 Tage
$796.95
Details

Weitere ELISA Kits für GFRA2 Interaktionspartner

Human GDNF Family Receptor alpha 2 (GFRA2) Interaktionspartner

  1. GFRA2 was upregulated in human neuroblastoma cells and tissues, and promoted neuroblastoma cell proliferation through interacting with the tumor suppressor PTEN.

  2. A novel genome-wide significant locus at GFRA2 on chromosome 8p21.3 was identified to be associated with disease risk, and expression analyses showed that the risk-associated allele at rs36196656 decreased GFRA2 mRNA concentrations in GFRA2 tissue.

  3. biophysical results show that the relative concentration of GFRa2 on cell surfaces can affect the functional affinity of NRTN through avidity effects.

  4. The cardiac GFRA2 signaling pathway is distinct from the canonical pathway dependent on the RET tyrosine kinase.

  5. High GFRalpha2 expression level leads to PTEN inactivation via Mir-17-5p up-regulation, promoting pancreatic tumor cell growth and chemoresistance.

  6. GFRA2 variants associated with diabetic neuropathic pain.

  7. GFRalpha2 is under-expressed in functioning adenomas and over-expressed in non-functioning adenomas, specifically gonadotropinomas

  8. In the cochlea, immunolabeling for GFRalpha-2 receptors was identified mainly in the cell bodies of the spiral neurons than in the nerve fibers. No structures in the organ of Corti were labeled with GFRalpha-2 receptor antibody

  9. The study shows co-localization of RET with GFRA1 and GFRA2 in myenteric ganglia of the adult human colon.

  10. GFRalpha-2 is associated with severe abdominal pain sensation in pancreatic cancer patients.

  11. Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRalpha2 isoforms.

  12. GFRA2 genetic variants, and age, may play a role in susceptibility to tardive dyskinesia.

  13. This study found nominally-significant evidence for interactions between GFRA1, 2 and 3 associated with schizophrenia and clozapine response, consistent with the locations of these three genes within linkage regions for schizophrenia.

  14. Both GFR alpha2a and GFR alpha2c, but not GFR alpha2b, promote neurite outgrowth in transfected Neuro2A cells.

  15. GFRalpha-2 were observed within sensory and motor nuclei of cranial nerves, dorsal column nuclei, olivary nuclear complex, reticular formation, pontine nuclei, locus caeruleus, raphe nuclei, substantia nigra, and quadrigeminal plate.

Mouse (Murine) GDNF Family Receptor alpha 2 (GFRA2) Interaktionspartner

  1. The cardiac GFRA2 signaling pathway is distinct from the canonical pathway dependent on the RET tyrosine kinase.

  2. Ret and Gfra2 null mice display comparable early central projection deficits, but Gfra2 null rapidly adapting mechanoreceptors recover later.

  3. neurons switch their GFRalpha signaling pathways during postnatal development

  4. STAT3 phosphorylation by neurturin was found to be mediated specifically by GFRalpha2c and RET9 isoforms.

  5. Cholinergic innervation of gastric mucosa depends on neurturin-GFRalpha2 signalling but is dispensable for gastrin secretion and for basal and maximal acid output

  6. our data demonstrate that RET/GFRalpha signals are dispensable for thymic T cell development in vivo

  7. Transduction-function role for GFR alpha2/neurturin signalling in a specific class of sensory neurons.

  8. growth retardation in mice lacking GFRalpha2 is largely due to impaired salivary and pancreatic secretion and intestinal dysmotility.

  9. The cholinergic subpopulation of sympathetic neurons requires GFR alpha 2 signaling for soma size and for growth or maintenance of target innervation.

  10. The knockout mice of GFRalpha2 displayed significant impairment in contextual fear conditioning and conditioned taste aversion tests of memory.

  11. GFRalpha2 signaling is needed for development of the parasympathetic islet innervation that is critical for vagally induced hormone secretion.

  12. Critical role for endogenous GFRalpha2 signaling in maintaining the size and terminal innervation of the nonpeptidergic class of cutaneous nociceptors in vivo.

  13. Increased apoptosis of parasympathetic but not enteric neurons in the developing pancreas of mice lacking GFRalpha2.

  14. Demonstrate a role for GFRalpha2-expressing enteric neurons in the downstream signaling of the glucagon-like peptides to inhibit GI motility, but not in intestinal growth.

Cow (Bovine) GDNF Family Receptor alpha 2 (GFRA2) Interaktionspartner

  1. GFRA2 influences basal metabolic rates, suggesting a mechanism by which genetic variation may contribute to Residual feed intake.

GFRA2 Antigen-Profil

Beschreibung des Gens

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit GFRA2

  • GDNF family receptor alpha 2 (GFRA2) Antikörper
  • glial cell line derived neurotrophic factor family receptor alpha 2 (Gfra2) Antikörper
  • GDNF family receptor alpha 2 (Gfra2) Antikörper
  • GDNF family receptor alpha 2 (gfra2) Antikörper
  • GDNF family receptor alpha 2a (gfra2a) Antikörper
  • gdnfrb Antikörper
  • gfra2 Antikörper
  • nrtnr-alpha Antikörper
  • ntnra Antikörper
  • NTNRALPHA Antikörper
  • retl2 Antikörper
  • trnr2 Antikörper

Bezeichner auf Proteinebene für GFRA2

GDNF family receptor alpha-2 , GDNF receptor beta , GDNFR-alpha-2 , GDNFR-beta , GFR-alpha 2 , NTNR-alpha , PI-linked cell-surface accessory protein , RET ligand 2 , TGF-beta-related neurotrophic factor receptor 2 , TRN receptor, GPI-anchored , glial cell line derived neurotrophic factor receptor, beta , neurturin receptor alpha , GDNF receptor alpha-2 , GFR alpha 2 , GFR alpha-2 , GFR-alpha-2 , NRTNR-alpha , CDC42 binding protein kinase alpha (DMPK-like) , glial cell line derived neurotrophic factor family receptor alpha 2 , tyrosine kinase receptor ligand 2 , GDNF family receptor alpha 2 , GDNF family receptor alpha-2-like

GENE ID SPEZIES
2675 Homo sapiens
14586 Mus musculus
100157850 Sus scrofa
25136 Rattus norvegicus
395993 Gallus gallus
514036 Bos taurus
100127717 Xenopus (Silurana) tropicalis
100171804 Pongo abelii
405794 Danio rerio
609172 Canis lupus familiaris
100475044 Ailuropoda melanoleuca
100727079 Cavia porcellus
100146260 Equus caballus
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