anti-G Protein-Coupled Receptor 17 (GPR17) Antikörper

Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Zusätzlich bieten wir Ihnen GPR17 Proteine (4) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
GPR17 2840 Q13304
GPR17 574402 Q6NS65
GPR17 767613 Q09QM4
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Top anti-GPR17 Antikörper auf antikoerper-online.de

Showing 10 out of 108 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Ziege Unkonjugiert ELISA, IHC, WB Antibody (0.1µg/ml) staining of Human Cerebellum lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Antibody (0.3µg/ml) staining of Rat Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$429.84
Details
Human Kaninchen Unkonjugiert ICC, IHC (p) Immunocytochemistry/Immunofluorescence: GPR17 Antibody [NLS4229] - immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells. Immunohistochemistry-Paraffin: GPR17 Antibody [NLS4229] - IHC staining of human brain, neurons and glia. 0.05 mL Anmelden zum Anzeigen 10 bis 13 Tage
$516.98
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of GPR17 expression in HEK293T (A), Jurkat (B), NIH3T3 (C), rat kidney (D) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert IF, ELISA Immunofluorescence analysis of HeLa cells, using GPR17 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from LOVO cells, using GPR17 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Ziege Unkonjugiert ELISA, WB 0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$515.63
Details
Huhn Ziege Unkonjugiert ELISA, IHC, IHC (p), WB Anti-GPR17 antibody IHC staining of human heart, desmosomes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1101834 concentration 10 ug/ml. Anti-GPR17 antibody IHC of human heart, desmosomes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Human Kaninchen Unkonjugiert ICC, IHC, IHC (p) Anti-GPR17 antibody  ABIN1048753 IHC staining of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-GPR17 antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Anti-GPR17 antibody  ABIN1048752 IHC staining of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-GPR17 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, IHC (p) Anti-GPR17 antibody  ABIN1048754 IHC staining of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-GPR17 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details

Am meisten referenzierte anti-GPR17 Antikörper

  1. Human Polyclonal GPR17 Primary Antibody für ICC, IHC (p) - ABIN271042 : Ciana, Fumagalli, Trincavelli, Verderio, Rosa, Lecca, Ferrario, Parravicini, Capra, Gelosa, Guerrini, Belcredito, Cimino, Sironi, Tremoli, Rovati, Martini, Abbracchio: The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. in The EMBO journal 2006 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal GPR17 Primary Antibody für ELISA, WB - ABIN4315679 : Parravicini, Ranghino, Abbracchio, Fantucci: GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors. in BMC bioinformatics 2008 (PubMed)

Weitere Antikörper gegen GPR17 Interaktionspartner

Human G Protein-Coupled Receptor 17 (GPR17) Interaktionspartner

  1. In silico and ex vivo validation experiments provided the deep understanding of ligand binding with GPR17 and the present findings reported here may lead to use these two compounds as a potential activator of GPR17 for therapeutic intervention.

  2. Results show a crucial role of SNX27 in modulating GPR17 levels by means of a post-translational mechanism and highlights the relationship between the trafficking of the receptor through the endomembrane system and oligodendrocyte differentiation; and provide novel evidence of impairment of GPR17 expression and oligodendrocyte maturation in a mouse model of Down syndrome that is characterized by SNX27 down-regulation.

  3. uracil nucleotides and cysteinyl leukotrienes do not activate human, mouse, or rat GPR17 in various cellular backgrounds.

  4. GPR17 gene disruption does not alter food intake or glucose homeostasis in mice.

  5. This review summarizes knowledge about role of GPR17 receptors in physiology and pathology of nervous system, with special attention to remyelination processes.

  6. Low levels of GRK2/GRK5 causes a slow and not complete desensitization/down-regulation of GPR17.

  7. Data indicate that small molecule MDL29,951 activates human, mouse and rat orphan G protein-coupled receptor GPR17.

  8. Data validate GPR17 as a target for neurorepair

  9. Nucleotides, nucleotide sugars, and cysteinyl leukotrienes do not promote activation of GPR17 in five different cell lines, nor does GPR17 have signaling properties.

  10. analysis of agonist-induced trafficking of native GPR17 in oligodendroglial cells

  11. A functional cross-talk exists between cysteinyl-leukotriene and purinergic sites at GPR17; the latter have a hierarchy in producing desensitizing signals.

  12. REVIEW: functional properties and in vivo biology

  13. We present the first isoform-specific characterization of GPR17 and show that differences exist between the isoforms in expression pattern and pharmacological profile; the two human isoforms might serve tissue-specific functions

  14. GPR17, a Gi-coupled orphan receptor at intermediate phylogenetic position between P2Y and CysLT receptors, is specifically activated by both families of endogenous ligands.

  15. Molecular dynamics simulations suggest that GPR17 nucleotide binding pocket is similar to that described for the other P2Y receptors, although only one of the 3 basic residues that have been typically involved in ligand recognition is conserved (Arg255).

  16. long-GPR17 isoform is a functional receptor that is stimulated by both uracil nucleotides and cysteinyl leukotrienes

Mouse (Murine) G Protein-Coupled Receptor 17 (GPR17) Interaktionspartner

  1. Study defined the differentiation capabilities of GPR17+ cells in rodents after myelin disruption in two different models, the former characterized by diffused immune response against myelin components and strong inflammation (the EAE model), and the latter one consisting in local demyelination induced by a toxic agent (the cuprizone model).

  2. Study finds that transcription factor FoxO1 exerts integrative control of leptin, insulin, and amino acid signaling in AgRP neurons, effectively coordinating food intake with peripheral metabolism; and identifies of a heretofore unrecognized FoxO1 pathway that regulates food intake through the G protein-coupled receptor, Gpr17.

  3. Agrp-Gpr17(-/-) mice show reduced food intake, increased relative energy expenditure, and increased satiety, resulting in leanness and reduced body fat. They also show increased central nervous system sensitivity to insulin and leptin.

  4. The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke.

  5. Results show a crucial role of SNX27 in modulating GPR17 levels by means of a post-translational mechanism and highlights the relationship between the trafficking of the receptor through the endomembrane system and oligodendrocyte differentiation; and provide novel evidence of impairment of GPR17 expression and oligodendrocyte maturation in a mouse model of Down syndrome that is characterized by SNX27 down-regulation.

  6. The loss of Gpr17 in mice led to precocious myelination and an earlier onset of remyelination after demyelination

  7. uracil nucleotides and cysteinyl leukotrienes do not activate human, mouse, or rat GPR17 in various cellular backgrounds.

  8. GPR17(+) cells--in contrast to GPR17(-) NG2-glia--did not differentiate within 3 months, a peculiarity that was overcome after cerebral damage induced by acute injury or ischemia

  9. stimulation of GPR17 by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein expression levels mainly by triggering the Galphai/o signaling pathway.

  10. The mouse GPR17 receptor plays a central role in the early response of cardiac stromal cells to ischaemia.

  11. Data indicate that small molecule MDL29,951 activates human, mouse and rat orphan G protein-coupled receptor GPR17.

  12. GPR17 is a marker for progenitor progression within the oligodendroglial lineage that participates in postacute reactivity of NG2-proteoglycan expressing cells in different injury paradigms.

  13. CysLT1R, CysLT2R and GPR17 might be involved in the MPTP-induced Parkinson disease damage in mice.

  14. analysis of agonist-induced trafficking of native GPR17 in oligodendroglial cells

  15. GPR17 is expressed by a subpopulation of oligodendrocyte precursor cells, but not by astrocytes; this expression pattern is also confirmed in vivo. In vitro, GPR17 expression is markedly influenced by culturing conditions.

  16. GPR17 negatively regulates type 1 cysteinyl leukotriene receptor (CysLT1R)-mediated inflammatory cell accumulation in the bronchoalveolar lavage fluid and lung, in both the antigen presentation and downstream phases of allergic pulmonary inflammation.

  17. GPR17 orchestrates the transition between immature and myelinating oligodendrocytes via an ID protein-mediated negative regulation and may serve as a potential therapeutic target for CNS myelin repair.

GPR17 Antigen-Profil

Protein Überblick

Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.

Genbezeichner und Symbole assoziert mit GPR17

  • G protein-coupled receptor 17 (GPR17) Antikörper
  • G protein-coupled receptor 17 (Gpr17) Antikörper
  • AI853548 Antikörper
  • GPR17 Antikörper

Bezeichner auf Proteinebene für GPR17

G protein-coupled receptor 17 , uracil nucleotide/cysteinyl leukotriene receptor-like , uracil nucleotide/cysteinyl leukotriene receptor , G-protein coupled receptor 17 , P2Y-like receptor , R12 , UDP/CysLT receptor

GENE ID SPEZIES
699576 Macaca mulatta
769024 Gallus gallus
100444185 Pongo abelii
100593986 Nomascus leucogenys
100611956 Pan troglodytes
782442 Bos taurus
2840 Homo sapiens
574402 Mus musculus
767613 Rattus norvegicus
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