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Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Zusätzlich bieten wir Ihnen GPR17 Proteine (4) und und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal GPR17 Primary Antibody für ICC, IHC (p) - ABIN271042
Ciana, Fumagalli, Trincavelli, Verderio, Rosa, Lecca, Ferrario, Parravicini, Capra, Gelosa, Guerrini, Belcredito, Cimino, Sironi, Tremoli, Rovati, Martini, Abbracchio: The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. in The EMBO journal 2006
Show all 2 Pubmed References
Human Polyclonal GPR17 Primary Antibody für ELISA, WB - ABIN4315679
Parravicini, Ranghino, Abbracchio, Fantucci: GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors. in BMC bioinformatics 2008
In silico and ex vivo validation experiments provided the deep understanding of ligand binding with GPR17 and the present findings reported here may lead to use these two compounds as a potential activator of GPR17 for therapeutic intervention.
Results show a crucial role of SNX27 (zeige SNX27 Antikörper) in modulating GPR17 levels by means of a post-translational mechanism and highlights the relationship between the trafficking of the receptor through the endomembrane system and oligodendrocyte differentiation; and provide novel evidence of impairment of GPR17 expression and oligodendrocyte maturation in a mouse model of Down syndrome that is characterized by SNX27 (zeige SNX27 Antikörper) down-regulation.
uracil nucleotides and cysteinyl leukotrienes do not activate human, mouse, or rat GPR17 in various cellular backgrounds.
GPR17 gene disruption does not alter food intake or glucose homeostasis in mice.
This review summarizes knowledge about role of GPR17 receptors in physiology and pathology of nervous system, with special attention to remyelination processes.
Low levels of GRK2 (zeige ADRBK1 Antikörper)/GRK5 (zeige GRK5 Antikörper) causes a slow and not complete desensitization/down-regulation of GPR17.
Data indicate that small molecule MDL29,951 activates human, mouse and rat orphan G protein-coupled receptor (zeige GPRC5D Antikörper) GPR17.
Data validate GPR17 as a target for neurorepair
Nucleotides, nucleotide sugars, and cysteinyl leukotrienes do not promote activation of GPR17 in five different cell lines, nor does GPR17 have signaling properties.
analysis of agonist-induced trafficking of native GPR17 in oligodendroglial cells
The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke.
The loss of Gpr17 in mice led to precocious myelination and an earlier onset of remyelination after demyelination
GPR17(+) cells--in contrast to GPR17(-) NG2 (zeige Vcan Antikörper)-glia--did not differentiate within 3 months, a peculiarity that was overcome after cerebral damage induced by acute injury or ischemia
stimulation of GPR17 by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein (zeige MBP Antikörper) expression levels mainly by triggering the Galphai/o signaling pathway.
Agrp (zeige AGRP Antikörper)-Gpr17(-/-) mice show reduced food intake, increased relative energy expenditure, and increased satiety, resulting in leanness and reduced body fat. They also show increased central nervous system sensitivity to insulin (zeige INS Antikörper) and leptin (zeige LEP Antikörper).
The mouse GPR17 receptor plays a central role in the early response of cardiac stromal cells to ischaemia.
Data indicate that small molecule MDL29,951 activates human, mouse and rat orphan G protein-coupled receptor (zeige GPRC5C Antikörper) GPR17.
GPR17 is a marker for progenitor progression within the oligodendroglial lineage that participates in postacute reactivity of NG2 (zeige Vcan Antikörper)-proteoglycan (zeige Vcan Antikörper) expressing cells in different injury paradigms.
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.
G protein-coupled receptor 17
, uracil nucleotide/cysteinyl leukotriene receptor-like
, uracil nucleotide/cysteinyl leukotriene receptor
, G-protein coupled receptor 17
, P2Y-like receptor
, UDP/CysLT receptor