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Endothelial receptor that acts as an essential regulator of CNS angiogenesis.
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Data suggest that GPR124 promotes cell adhesion via interaction with Elmo1-Dock180 (zeige DOCK1 ELISA Kits) and intersectin 1 (zeige ITSN1 ELISA Kits)/2; this constitutes a previously unrecognized heteromeric complex that is putatively involved in GPR124-dependent adhesive/angiogenic responses in vascular endothelial cells. (GPR124 = G-protein coupled receptor 124; Elmo1 = ELMO domain-containing protein 1; Dock180 (zeige DOCK1 ELISA Kits) = dedicator of cytokinesis protein 1 (zeige DOCK1 ELISA Kits) 180 kDa)
Observed an inverse correlation between the expression of miR (zeige MLXIP ELISA Kits)-138-5p and GPR124 in lung adenocarcinoma specimens. Knockdown of GPR124 mimicked the effects of miR (zeige MLXIP ELISA Kits)-138-5p on the sensitivity to gefitinib.
Thrombin (zeige F2 ELISA Kits)-induced shedding of tumour endothelial marker 5 and exposure of its RGD motif are regulated by cell-surface protein (zeige CD28 ELISA Kits) disulfide-isomerase (zeige P4HB ELISA Kits).
TEM5 expression during capillary morphogenesis is induced by the small GTPase (zeige RACGAP1 ELISA Kits) Rac (zeige AKT1 ELISA Kits) and mediates contact inhibition of proliferation in endothelial cells.
Proteolytically processed soluble tumor endothelial marker TEM5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v (zeige ITGAV ELISA Kits))beta3 to glycosaminoglycans
experiments indicate that Reck (zeige RECK ELISA Kits) and Gpr124 are part of the cell surface protein (zeige CD28 ELISA Kits) complex that transduces Wnt7a (zeige WNT7A ELISA Kits)- and Wnt7b (zeige WNT7B ELISA Kits)-specific signals in mammalian CNS Epithelial Cells to promote angiogenesis and regulate the BBB (zeige ALMS1 ELISA Kits).
Gpr124 is an endothelial GPCR (zeige GPBAR1 ELISA Kits) specifically required for endothelial Wnt (zeige WNT2 ELISA Kits) signaling and BBB (zeige ALMS1 ELISA Kits) integrity under pathological conditions in adult mice.
Vital role for GPR124 is potentiation of WNT7 (zeige WNT7B ELISA Kits)-induced canonical beta-catenin (zeige CTNNB1 ELISA Kits) signaling with important implications for understanding and manipulating CNS-specific angiogenesis.
Gpr124 functions as coactivator of Wnt7a (zeige WNT7A ELISA Kits)- and Wnt7b (zeige WNT7B ELISA Kits)-stimulated canonical Wnt (zeige WNT2 ELISA Kits) signaling via Frizzled receptor and Lrp (zeige LRP1 ELISA Kits) coreceptor and that Gpr124-stimulated signaling functions in concert with Norrin (zeige NDP ELISA Kits)/Frizzled4 (zeige FZD4 ELISA Kits) signaling to control CNS vascular development
GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.
TGF-beta (zeige TGFB1 ELISA Kits) stimulates Gpr124 expression which is required for angiogenic sprouting into neural tissues.
study shows that complete null or endothelial-specific GPR124 deletion resulted in embryonic lethality from CNS-specific angiogenesis arrest in forebrain and neural tube; results demonstrate CNS-specific angiogenesis regulation by an endothelial receptor
The GPI (zeige ITGA2 ELISA Kits)-anchored MMP inhibitor Reck (zeige RECK ELISA Kits) and the adhesion GPCR (zeige GPRC6A ELISA Kits) Gpr124 are integral components of the Wnt7a (zeige WNT7A ELISA Kits)/Wnt7b (zeige WNT7B ELISA Kits)-specific signaling complex required for brain angiogenesis and dorsal root ganglia neurogenesis.
Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube.
G-protein coupled receptor 124
, tumor endothelial marker 5
, G protein-coupled receptor 124
, probable G-protein coupled receptor 124-like