anti-Fused in Sarcoma (FUS) Antikörper

FUS encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. Zusätzlich bieten wir Ihnen FUS Kits (3) und FUS Proteine (2) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
FUS 2521 P35637
FUS 233908 P56959
FUS 317385  
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Top anti-FUS Antikörper auf antikoerper-online.de

Showing 10 out of 45 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert EIA, FACS, IF, IHC (p), WB Flow cytometric analysis of Hela cells using FUS Antibody (C-term) Cat.-No AP51735PU-N (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Confocal immunofluorescent analysis of FUS Antibody (C-term) Cat.-No AP51735PU-N with MDA-MB231 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Maus Unkonjugiert IF, WB Western blot analysis of TLS on a Jurkat cell lysate. Lane 1: 1:250, Lane 2: 1:500, Lane 3: 1:1000 dilution of the anti- TLS antibody. 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$168.74
Details
Human Kaninchen Unkonjugiert IHC (p), IP, WB 50 μL Anmelden zum Anzeigen 7 bis 9 Tage
$595.83
Details
Human Kaninchen Unkonjugiert IHC (p), WB Human Breast (formalin-fixed, paraffin-embedded) stained with FUS antibody ABIN462224 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Small Intestine (formalin-fixed, paraffin-embedded) stained with FUS antibody ABIN462224 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$727.83
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$390.50
Details
Human Kaninchen Unkonjugiert ELISA, FACS, IF, IHC, WB   200 μL Anmelden zum Anzeigen 7 bis 9 Tage
$793.83
Details
Human Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$815.83
Details
Human Kaninchen Unkonjugiert IHC (p), ELISA, WB   100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$845.17
Details
Human Kaninchen FITC IHC, ELISA, WB   100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$581.17
Details
Human Kaninchen Biotin IHC, ELISA, WB   100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$581.17
Details

FUS Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-FUS Antikörper

  1. Human Monoclonal FUS Primary Antibody für IF, WB - ABIN968508 : Hallier, Lerga, Barnache, Tavitian, Moreau-Gachelin: The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS. in The Journal of biological chemistry 1998 (PubMed)
    Show all 5 Pubmed References

  2. Human Monoclonal FUS Primary Antibody für IF, WB - ABIN968509 : Morohoshi, Ootsuka, Arai, Ichikawa, Mitani, Munakata, Ohki: Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes. in Gene 1998 (PubMed)
    Show all 5 Pubmed References

Weitere Antikörper gegen FUS Interaktionspartner

Human Fused in Sarcoma (FUS) Interaktionspartner

  1. A molecular docking and dynamics study concluded that R521C and R521H mutations in FUS result in weak binding with Karyopherin-beta2 leading to amyotrophic lateral sclerosis.

  2. both FUS and TDP43 (zeige TARDBP Antikörper) colocalize with active RNA polymerase II (zeige 0 Antikörper) at sites of DNA damage along with the DNA damage repair protein, BRCA1, and FUS and TDP43 (zeige TARDBP Antikörper) participate in the prevention or repair of R loop-associated DNA damage, a manifestation of aberrant transcription and/or RNA processing

  3. FUS mutations were significantly more common among mainland Chinese patients than those among Caucasian populations (p=6.8x10-3). The high frequency of FUS mutations in FALS and SALS (zeige CDH23 Antikörper) in mainland China is another genetic feature distinct from Caucasians.

  4. The impairment of PARP (zeige COL11A2 Antikörper)-dependent DNA damage response (DDR (zeige DDR1 Antikörper)) signaling due to mutations in the FUS nuclear localization sequence induces additional cytoplasmic FUS mislocalization which in turn results in neurodegeneration and FUS aggregate formation in amyotrophic lateral sclerosis.

  5. ALS (zeige IGFALS Antikörper)-associated mutations enhance FUS protein propagation in Drosophila neurons.

  6. juvenile ALS (zeige IGFALS Antikörper) linked to FUS mutations represent a specific entity different from both classical juvenile ALS (zeige IGFALS Antikörper) and adult ALS (zeige IGFALS Antikörper) linked to FUS gene

  7. Motor neurons expressing FUS with the P525L or the R521H mutation showed cytoplasmic mislocalization of FUS, hypoexcitability, and axonal transport defects.

  8. Results suggest that RBM45 (zeige RBM45 Antikörper) serves as a negative regulator to prevent FUS-mediated excessive recruitment of HDAC1 (zeige HDAC1 Antikörper) to the sites of DNA damage.

  9. Authors found that FUS, EWS (zeige EWSR1 Antikörper) and TAF15 (zeige TAF15 Antikörper) expression is differentially regulated during brain development, both in time and in space. In particular, this study identifies a fine-tuned regulation of FUS and EWS (zeige EWSR1 Antikörper) during neuronal differentiation.

  10. The review describes the main physiological functions of FUS and considers evidence for each of the theories of amyotrophic lateral sclerosis pathogenesis.

Mouse (Murine) Fused in Sarcoma (FUS) Interaktionspartner

  1. These two proteins were up-regulated in both HD and FUS/TLS heterozygote mice.

  2. Study established that Fus1 (zeige TUSC2 Antikörper) KO mice suffer from the age-related hearing loss (ARHL) of strial origin, making this model a valuable tool for studying mitochondrial/oxidative mechanisms of age-related hearing decline. The model describes the phenotype of premature hearing loss of strial etiology based on Fus1 (zeige TUSC2 Antikörper) loss-mediated mitochondrial dysfunction, and identify the target cells and tissues in the inner ear.

  3. Authors found that FUS, EWS (zeige EWSR1 Antikörper) and TAF15 (zeige TAF15 Antikörper) expression is differentially regulated during brain development, both in time and in space. In particular, this study identifies a fine-tuned regulation of FUS and EWS (zeige EWSR1 Antikörper) during neuronal differentiation.

  4. Study characterizes a heterozygous knock-in mouse model of ALS and demonstrates that mutations in FUS result in a toxic gain of function leading to motor neuron disease through cell autonomous and non-cell autonomous mechanisms; shows that mutant FUS triggers toxic events in both motor neurons and neighboring cells to elicit motor neuron disease.

  5. FUS-induced reductions to ER-mitochondria associations and are linked to activation of glycogen synthase kinase-3beta (GSK-3beta), a kinase already strongly associated with ALS/FTD (zeige FTL Antikörper).

  6. our findings indicate that cytoplasmic FUS mislocalization not only leads to nuclear loss of function, but also triggers motor neuron death through a toxic gain of function within motor neurons.

  7. The data of this study support the notion that expression of cytoplasmically mislocalized FUS with compromised RNA-binding capacity causes particularly prominent and harmful FUS pathology in the mouse nervous system.

  8. These results highlight the pivotal role of FUS in regulating GluA1 (zeige GRIA1 Antikörper) mRNA stability, post-synaptic function and fronto-temporal lobar degeneration-like animal behaviors.

  9. these studies establish potentially converging disease mechanisms in amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy, with ALS-causative mutants acquiring properties representing both gain and loss of function.

  10. FUS/TLS depletion causes phenotypes possibly related to neuropsychiatric and neurodegenerative conditions, but distinct from ALS and ET, together with specific alterations in RNA metabolisms.

FUS Antigen-Profil

Protein Überblick

This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.

Genbezeichner und Symbole assoziert mit anti-Fused in Sarcoma (FUS) Antikörper

  • FUS RNA binding protein (FUS) Antikörper
  • fused in sarcoma (Fus) Antikörper
  • FUS RNA binding protein (Fus) Antikörper
  • fused in sarcoma (FUS) Antikörper
  • ALS6 Antikörper
  • D430004D17Rik Antikörper
  • D930039C12Rik Antikörper
  • ETM4 Antikörper
  • FUS/TLS Antikörper
  • Fus1 Antikörper
  • HNRNPP2 Antikörper
  • POMP75 Antikörper
  • Tls Antikörper

Bezeichner auf Proteinebene für anti-Fused in Sarcoma (FUS) Antikörper

75 kDa DNA-pairing protein , RNA-binding protein FUS , fus-like protein , fusion gene in myxoid liposarcoma , heterogeneous nuclear ribonucleoprotein P2 , oncogene FUS , oncogene TLS , translocated in liposarcoma protein , fusion, derived from t(12;16) malignant liposarcoma , hnRNP P2 , pigpen protein , protein pigpen , translocated in liposarcoma , fusion , pigpen , fusion (involved in t(12;16) in malignant liposarcoma) , 16) in malignant liposarcoma) , 16) malignant liposarcoma , fusion (involved in t(12 , fusion, derived from t(12

GENE ID SPEZIES
2521 Homo sapiens
233908 Mus musculus
414144 Gallus gallus
280796 Bos taurus
317385 Rattus norvegicus
479778 Canis lupus familiaris
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