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The protein encoded by FH is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. Zusätzlich bieten wir Ihnen FH Antikörper (194) und FH Proteine (22) und viele weitere Produktgruppen zu diesem Protein an.
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Induction of ferroptosis in fumarate hydratase-inactivated tumors represents an opportunity for synthetic lethality in cancer.
A case series of 2 sisters in their 20s who presented with isolated uterine leiomyomas and were found to carry a novel mutation for the fumarate hydratase gene.
The clinical spectrum associated with hereditary leiomyomatosis and renal cell carcinoma syndrome in French FH mutation carriers has been reassessed.
As with many emerging cancer syndromes, the phenotypic spectrum ofhereditary leiomyomatosis and renal cell cancer( HLRCC) is likely to expand as the FH gene becomes incorporated on more multiplex germline panels, which will also help to clarify the potential involvement of other tumor types in HLRCC
We show that the mechanism of fumarate hydratase distribution is alternative transcription initiation from a broad promoter.
fumarate increases ferritin (zeige FTL ELISA Kits) gene transcription by activating the NRF2 (zeige GABPA ELISA Kits) (nuclear factor [erythroid-derived 2]-like 2) transcription factor.
FH-Ser75 phosphorylation level inversely correlates with the OGT (zeige OGT ELISA Kits) level and poor prognosis in pancreatic cancer patients. Report mechanism underlying transcription regulation by FH and the linkage between dysregulated OGT (zeige OGT ELISA Kits) activity and growth advantage of cancer cells under glucose deficiency.
Loss of FH immunohistochemical (IHC) expression in cutaneous leiomyomas is a sensitive and specific marker for detection of hereditary leiomyomatosis and renal cell carcinoma (HLRCC). FH expression by IHC was absent in 9 specimens and retained in 85 specimens and 2 cases were equivocal with minimal FH expression while succinate dehydrogenase B (zeige SDHB ELISA Kits) expression was retained in 95 specimens and equivocal in 1 specimen.
LSH promoted cancer progression in part by regulating expression of fumarate hydratase (FH).
Cascade FH mutation screening enabled the early diagnosis of a renal tumour in an asymptomatic parent of a child with fumarate hydratase deficiency, resulting in timely and possibly life-saving treatment.
roles for fumarate metabolism in hematopoietic stem cell (HSC) maintenance and hematopoietic differentiation and reveal a differential requirement for mitochondrial Fh1 in normal hematopoiesis and leukemia propagation.
Adipose-Specific Deficiency of Fumarate Hydratase in Mice Protects Against Obesity, Hepatic Steatosis, and Insulin (zeige INS ELISA Kits) Resistance.
Reexpression of cytosolic FH in FH1-deficient mice is critical for the suppression of renal cyst development and restoration of defects in the arginine biosynthesis pathway.
Tumor-derived FH and SDH mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple alpha-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation.
identification of a metabolic pathway that is induced in Fh1-deficient cells to demonstrate that inhibition of haem oxygenation is synthetically lethal when combined with Fh1 deficiency, providing a new potential target for treating HLRCC patients
These experiments demonstrated that upregulation of HIF-1alpha (zeige HIF1A ELISA Kits) occurs as a direct consequence of FH inactivation.
progression of tumors where FH is lost might be boosted by activation of the MET oncogene (zeige RAB1A ELISA Kits), which is able to drive cell-autonomous tumor progression
The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.
fumarate hydratase, mitochondrial
, fumarate hydratase
, fumarate hydratase 1