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The protein encoded by FH is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. Zusätzlich bieten wir Ihnen FH Kits (22) und FH Proteine (20) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 186 products:
Human Monoclonal FH Primary Antibody für ELISA, WB - ABIN515646
Kov?ová, Mrá?ek, N?sková, Holzerová, Vrbacký, Pecina, Hejzlarová, K?u?ková, Rohlena, Neuzil, Houšt?k: High molecular weight forms of mammalian respiratory chain complex II. in PLoS ONE 2013
Show all 2 Pubmed References
Human Polyclonal FH Primary Antibody für ICC, IF - ABIN441343
Burkart, Tan, Warren, Iovino, Hughes, Kahn, Patti: Insulin Resistance in Human iPS Cells Reduces Mitochondrial Size and Function. in Scientific reports 2016
Human Polyclonal FH Primary Antibody für ELISA, WB - ABIN253302
Pollard, Spencer-Dene, Shukla, Howarth, Nye, El-Bahrawy, Deheragoda, Joannou, McDonald, Martin, Igarashi, Varsani-Brown, Rosewell, Poulsom, Maxwell, Stamp, Tomlinson: Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. in Cancer cell 2007
We show that the mechanism of fumarate hydratase distribution is alternative transcription initiation from a broad promoter.
fumarate increases ferritin (zeige FTL Antikörper) gene transcription by activating the NRF2 (zeige GABPA Antikörper) (nuclear factor [erythroid-derived 2]-like 2) transcription factor.
FH-Ser75 phosphorylation level inversely correlates with the OGT (zeige OGT Antikörper) level and poor prognosis in pancreatic cancer patients. Report mechanism underlying transcription regulation by FH and the linkage between dysregulated OGT (zeige OGT Antikörper) activity and growth advantage of cancer cells under glucose deficiency.
Loss of FH immunohistochemical (IHC) expression in cutaneous leiomyomas is a sensitive and specific marker for detection of hereditary leiomyomatosis and renal cell carcinoma (zeige MOK Antikörper) (HLRCC). FH expression by IHC was absent in 9 specimens and retained in 85 specimens and 2 cases were equivocal with minimal FH expression while succinate dehydrogenase B (zeige SDHB Antikörper) expression was retained in 95 specimens and equivocal in 1 specimen.
LSH (zeige HELLS Antikörper) promoted cancer progression in part by regulating expression of fumarate hydratase (FH).
Cascade FH mutation screening enabled the early diagnosis of a renal tumour in an asymptomatic parent of a child with fumarate hydratase deficiency, resulting in timely and possibly life-saving treatment.
Mutations in some enzymes of the TCA cycle: Isocitrate dehydrogenase (IDH (zeige IDH1 Antikörper)), succinate dehydrogenase (SDH (zeige SDHA Antikörper)) and fumarate hydratase (FH) are associated with the accumulation of metabolites that are able to influence many aspects of cancer development and progression and for this reason are termed onco-metabolites.
After indirect co-culture, OP was increased in the BxPc-3 and Panc-1 cells; correspondingly, succinate dehydrogenase (zeige SDHA Antikörper), FH and MCT (zeige MCAT Antikörper) expression were increased. After the MCT1 (zeige CMA1 Antikörper)-specific inhibitor removed 'tumor-stromal' metabolic coupling, the migration and invasion abilities of the pancreatic cancer cells were decreased.
A novel deletion of the Fumarate Hydratase (FH) gene was identified in a 22 year old male and his father, which predisposes to an aggressive form of renal cell cancer.
While the great majority of patients with hereditary leiomyomatosis and renal cell carcinoma (zeige MOK Antikörper) will have FH-deficient leiomyomas, 1% of all uterine leiomyomas are FH deficient usually due to somatic inactivation.
roles for fumarate metabolism in hematopoietic stem cell (HSC) maintenance and hematopoietic differentiation and reveal a differential requirement for mitochondrial Fh1 in normal hematopoiesis and leukemia propagation.
Adipose-Specific Deficiency of Fumarate Hydratase in Mice Protects Against Obesity, Hepatic Steatosis, and Insulin (zeige INS Antikörper) Resistance.
Reexpression of cytosolic FH in FH1-deficient mice is critical for the suppression of renal cyst development and restoration of defects in the arginine biosynthesis pathway.
Tumor-derived FH and SDH (zeige SDS Antikörper) mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple alpha-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation (zeige HELLS Antikörper).
identification of a metabolic pathway that is induced in Fh1-deficient cells to demonstrate that inhibition of haem oxygenation is synthetically lethal when combined with Fh1 deficiency, providing a new potential target for treating HLRCC patients
These experiments demonstrated that upregulation of HIF-1alpha (zeige HIF1A Antikörper) occurs as a direct consequence of FH inactivation.
progression of tumors where FH is lost might be boosted by activation of the MET oncogene (zeige RAB1A Antikörper), which is able to drive cell-autonomous tumor progression
The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.
fumarate hydratase, mitochondrial
, fumarate hydratase
, fumarate hydratase 1