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FFAR2 encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. Zusätzlich bieten wir Ihnen FFAR2 Kits (7) und FFAR2 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal FFAR2 Primary Antibody für FACS, IF (p) - ABIN1713521
Kobayashi, Mikami, Kimura, Kamiyama, Morikawa, Yokoi, Kasuno, Takahashi, Taniguchi, Iwano: Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-α-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells. in Biochemical and biophysical research communications 2017
Compared with the control group, the densitometric quantification and mean density of GPR43 and ChAT proteins, and expression of GPR43 and CHAT genes, were significantly decreased in the patients with mixed refractory constipation.
a single dose of soluble fibre was able to significantly reduce airway inflammation in stable asthma by downregulating GPR43 and GPR41 (zeige FFAR3 Antikörper)
Short-chain fatty acids lowered TNF-alpha (zeige TNF Antikörper)-induced MCP-1 (zeige CCL2 Antikörper) expression by reducing phosphorylation of p38 MAPK (zeige MAPK14 Antikörper) and JNK (zeige MAPK8 Antikörper) in a GPR41 (zeige FFAR3 Antikörper)/GRP43-dependent manner in renal cortical epithelial cells.
FFA2 processes mediated by Gi signaling, whereas, in concert with blockade by the Gq/G11 (zeige STK19 Antikörper) inhibitor FR900359, the inability of AZ1729 to mimic or regulate propionate-mediated release of GLP-1 (zeige GCG Antikörper) from mouse colonic preparations defined this physiological response as an end point transduced via activation of Gq/G11 (zeige STK19 Antikörper).
the results of mutagenesis studies based on the crystal structure of hFFA1 bound to TAK (zeige CDK9 Antikörper)-875 at 2.3 A resolution to identify important residues for orthosteric agonist 6e inducing FFA2 activation.
Although both agonist and antagonist ligands contain negatively charged carboxylates that interact with two key positively charged arginine residues in transmembrane domains V and VII (zeige TH Antikörper) of FFA2, there are clear differences in how these interactions occur.
FFAR2 signaling occurs by divergent G protein pathways.
GPR3 agonism potentiates insulin secretion in isolated islets.
GPR43 expression is reduced in monocytes upon siRNA-knockdown of XBP1 (zeige XBP1 Antikörper), while A549 cells overexpressing XBP1 (zeige XBP1 Antikörper) displayed elevated GPR43 levels.
FFAR2 is a potential therapeutic target of T1 diabetes, representing a link between immune response and glucose homeostasis.
dual oxidase-2 (zeige DUOX1 Antikörper) and IL-6 (zeige IL6 Antikörper) play important roles in GPR43-mediated skin inflammation.
Loss of Ffar2 expression is associated with leukemia.
the role of GPR43 in adipose tissue macrophages, was examined.
loss of FFAR2 is associated with colon tumorigenesis.
Gestational glucose tolerance in WT mice, but not Ffar2-/- mice improved while on antibiotics. Gestational glucose tolerance worsened in Ffar2-/- mice during a second pregnancy. Maternal Ffar2 expression had no effect on the growth rates and glucose and glucose tolerance in the offspring.
A Western diet could aggravate the inflammatory colitis process; the activation of the GPR43 receptor pathway could be used as a new strategy to treat Crohn's Disease patients.
Data (including data from studies in knockout mice) suggest Ffar2 expression in pancreatic beta-cells plays role in gestational glucose homeostasis; this mechanism involves gut microbiome (which contributes to plasma short-chain fatty acid levels).
High fat diet fed GPR43 KO mice develop glucose intolerance due to a defect in insulin (zeige INS Antikörper) secretion, reduced beta-cell mass and expression of differentiation genes. GPR3 (zeige GPR3 Antikörper) agonism potentiates insulin (zeige INS Antikörper) secretion.
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels.
G protein-coupled receptor 43
, G-protein coupled receptor 43
, free fatty acid activated receptor 2
, leukocyte-specific STAT-induced GPCR