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The protein encoded by FXR2 is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. Zusätzlich bieten wir Ihnen Fragile X Mental Retardation, Autosomal Homolog 2 Antikörper (88) und Fragile X Mental Retardation, Autosomal Homolog 2 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
An accumulation of 8 SNPs in the fragile gene family (FMR1 (zeige FMR1 ELISA Kits), FXR1 (zeige FXR1 ELISA Kits) and FXR2)were found associated with autistic traits in a sample of male patients.
Data show that the nuclear localization signals of the FXR1 (zeige FXR1 ELISA Kits) and FXR2 comprise tandem Tudor domain architectures.
These results indicate that FMR1 (zeige FMR1 ELISA Kits) gene function is evolutionarily conserved in neural mechanisms and cannot be compensated by either FXR1 (zeige FXR1 ELISA Kits) or FXR2, but that all three proteins can substitute for each other in non-neuronal requirements.
FXR1P (zeige FXR1 ELISA Kits) and FXR2P KH2 (zeige KCNG1 ELISA Kits) domains bind G-quadruplex and kissing complex RNA with the same affinity as the FMRP (zeige FMR1 ELISA Kits) KH2 (zeige KCNG1 ELISA Kits) domain.
We discovered that FXR1P (zeige FXR1 ELISA Kits)-deficient aNSCs have altered expression of a select number of cell-cycle genes, and we identified the mRNA of cyclin-dependent kinase inhibitor 1A (Cdkn1a (zeige CDKN1A ELISA Kits), p21) as a direct target of FXR1P (zeige FXR1 ELISA Kits).
Both Fmr1 (zeige FMR1 ELISA Kits) and Fxr2 knockout mice have reduced fat deposits and glucose metabolism.
these findings show a coordinated regulation of PSD95/Dlg4 (zeige DLG4 ELISA Kits) mRNA by FMRP (zeige FMR1 ELISA Kits) and FXR2P that ultimately affects its fine-tuning during synaptic activity.
Differential regulation of SVZ and DG stem cells by FXR2 may be a key component of the mechanism that governs the different neurogenic processes in these two adult germinal.
Findings suggest that Fmr1 (zeige FMR1 ELISA Kits) and Fxr2 genes contribute in a cooperative manner to pathways controlling locomotor activity, sensorimotor gating and cognitive processes.
Fxr2 regulates mammalian circadian behavioral rhythms.
to unravel the function of Fxr2 protein, the expression pattern of 12,588 genes was studied in the brains of wild-type and Fxr2 knockout mice; genes and gene groups de-regulated in the brains of Fxr2 knockout mice were identified
The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome.
fragile X mental retardation syndrome-related protein 2
, fragile X mental retardation syndrome related protein 2
, fragile X mental retardation, autosomal homolog 2
, fragile X mental retardation syndrome-related protein 2-like
, fragile X-mental retardation 1-like 2
, fragile X mental retardation gene 2, autosomal homolog
, fragile X mental retardation-related protein 2