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This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. Zusätzlich bieten wir Ihnen FOXE1 Antikörper (56) und viele weitere Produktgruppen zu diesem Protein an.
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Report that PTCSC2 binds myosin-9 (MYH9 (zeige MYH9 Proteine)). In a bidirectional promoter shared by FOXE1 and PTCSC2, MYH9 (zeige MYH9 Proteine) inhibits the promoter activity in both directions. This inhibition can be reversed by PTCSC2, which acts as a suppressor.
replication confirmed at genome-wide significance the association of loci at FOXE1 with hypothyroidism, and PDE8B, CAPZB and PDE10A with serum TSH. A total of 12 SNPs seemed to explain nearly 7% of the serum TSH variation
The functional variants rs965513 and rs1867277 independently contribute to genetic predisposition to papillary thyroid carcinoma, while a contributing role of the FOXE1 poly-Ala polymorphism could not be confirmed.
FOXE1 interacts with ELK1 (zeige ELK1 Proteine) on thyroid relevant gene promoters, establishing a new regulatory pathway for its role in adult thyroid function. Co-regulation of TERT (zeige TERT Proteine) suggests a mechanism by which allelic variants in/near FOXE1 are associated with thyroid cancer risk.
In a Cuban population, differentiated thyroid cancer risk was positively and strongly associated with the number of copies in the minor allele (A) for SNP rs965513 near FOXE1 among people who consumed less iodine than the median.
methylation-mediated silencing of FOXE1 expression may contribute to the progression of CRC (zeige CALR Proteine).
Patient-related factors modify the predisposition to papillary thyroid carcinoma by increasing the risk for rs944289 (near the NKX2-1 locus) per year of age, and by enhancing the protective effect of the FOXE1 GGT haplotype in men.
We identified a FOXE1: c.532_537delGCCGCC p.(Ala178_Ala179del) variant that predisposes to thyroid ectopia. Taken together, this is the first report of mosaic 11p13 deletion in association with thyroid dysgenesis
Our results implicate FOXE1 as an important locus whose polymorphic variation increases risks for all types of isolated clefts, and opens a new biological pathway to investigate in efforts to understand genetic factors underlying human clefting.
FOXE1 polyalanine repeat polymorphisms are associated with thyroid cancer, but only for tumours larger than 1 cm, suggesting a role in disease progression.
These results indicate that Foxe1 overexpression is not directly involved in the development of thyroid cancer and that proper Foxe1 dosage is essential for achieving normal structure and function of the thyroid.
Foxe1 mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes.
MSX1 (zeige MSX1 Proteine) and TGF-beta3 (zeige TGFB3 Proteine) are direct targets of FOXE1.
Data report a detailed expression pattern of thyroid transcription factor-2 protein during mouse embryogenesis.
Foxe1 is required for hair follicle morphogenesis.
Xenopus FoxE1, a gene that is primarily expressed in the developing pituitary and thyroid
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I.
HNF-3/fork head-like protein 5
, forkhead box E2
, forkhead box protein E1
, forkhead box protein E2
, forkhead, drosophila, homolog-like 15
, forkhead-related protein FKHL15
, thyroid transcription factor 2
, forkhead box E1 (thyroid transcription factor 2)
, forkhead box E1
, forkhead box E protein