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FIGLA encodes a protein that functions in postnatal oocyte-specific gene expression. Zusätzlich bieten wir Ihnen FIGLA Antikörper (25) und FIGLA Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Biallelic mutations in FIGLA may be the cause of premature ovarian insufficiency (POI) . This study will aid researchers and clinicians in genetic counseling of POI and provides new insights into understanding the mode of genetic inheritance of FIGLA mutations in POI pathology.
study identified an association between FIGLA gene variants and the occurrence of premature ovarian failure(POF) in the Indian population; findings suggest that the c.427G->C and c.557C->T alleles lead to an increased risk of POF in Indian women
Expression of mRNA observed in ovarian follicles, mature oocytes, and less frequently in preimplantation embryos.
These results suggest that FIGLA is involved in continued oocyte survival as primordial follicles form in the human as in the rodent ovary.
the p.140 delN mutation disrupted FIGLA binding to the TCF3 helix-loop-helix (HLH) domain. Our findings show that a subset of Chinese women with sporadic, premature ovarian failure harbor mutations in FIGLA.
may have a role in the development of primordial follicle before zona pellucida formation
This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6.
, factor in the germline alpha
, transcription factor FIGa
, class C basic helix-loop-helix protein 8
, folliculogenesis-specific basic helix-loop-helix protein
, folliculogenesis specific basic helix-loop-helix
, folliculogenesis specific bHLH transcription factor L homeolog