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The protein encoded by FRS3 is a substrate for the fibroblast growth factor receptor.
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signaling via Pax6 expression through Shp2-binding sites of XFrs3 is necessary for the eye development in Xenopus laevis
Mechanisms by which FRS2beta acts as a feedback inhibitor of EGFR (zeige EGFR ELISA Kits) family members and suggest a role for FRS2beta as a tumor suppressor.
an FRS2beta-CIN85/CD2AP (zeige Cd2ap ELISA Kits)-Cbl (zeige CBL ELISA Kits) axis for downregulation of ErbB2 (zeige ERBB2 ELISA Kits) may regulate ErbB2 (zeige ERBB2 ELISA Kits) protein levels in physiological and pathological settings
FRS2 (zeige FRS2 ELISA Kits) PTB (zeige PTBP1 ELISA Kits) domain conformation regulates interactions with divergent neurotrophic receptors
FRS2beta can compensate for the loss of FRS2alpha (zeige FRS2 ELISA Kits) for activation of MAP kinase (zeige MAPK1 ELISA Kits) when expressed in fibroblasts
SNT-2 (zeige SNTB1 ELISA Kits) negatively regulates ERK2 (zeige MAPK1 ELISA Kits) signaling activated via EGF (zeige EGF ELISA Kits) stimulation through direct binding to ERK2 (zeige MAPK1 ELISA Kits)
Novel mechanism of negative control of EGFR (zeige EGFR ELISA Kits) tyrosine kinase (zeige TXK ELISA Kits) activity with SNT-2 (zeige SNTB1 ELISA Kits) by recruiting ERK2 (zeige MAPK1 ELISA Kits).
Analysis of a mutant Fgfr1 (zeige FGFR1 ELISA Kits) allele, unable to bind to the adaptor protein, Frs2 (zeige FRS2 ELISA Kits)/3, indicates that Sox2 (zeige SOX2 ELISA Kits) maintenance can be
data indicate that the fibroblast growth factor receptor substrate 2 (zeige FRS2 ELISA Kits) and fibroblast growth factor receptor substrate 3 adapters may have a role in thyroid carcinogenesis triggered by TRK (zeige NTRK1 ELISA Kits) oncogenes
Some essential functions of Fgfr1 (zeige FGFR1 ELISA Kits) are mediated by Frs (zeige SLC25A37 ELISA Kits)-independent signaling.
ULK2, by interaction with FRS2 (zeige FRS2 ELISA Kits)/3 and inhibition of SynGAP, functions to negatively regulate tyrosyl phosphorylation of signaling proteins downstream of FGFR1 (zeige FGFR1 ELISA Kits).
SNT family proteins may play significant roles in cellular transformation triggered by NPM-ALK.
The results showed that the interaction of full-length FRS2beta with FGFR1 (zeige FGFR1 ELISA Kits) was not enhanced by activation of the receptor kinase.
Prominent expression of Frs2beta protein in neural cells and its association with intracellular vesicles is reported.
The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras.
fibroblast growth factor receptor substrate 3
, FGFR substrate 3
, FGFR-signaling adaptor SNT2
, suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor)
, suc1-associated neurotrophic factor target 2