anti-Fermitin Family Member 3 (FERMT3) Antikörper

Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. Zusätzlich bieten wir Ihnen FERMT3 Kits (9) und FERMT3 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
FERMT3 108101 Q8K1B8
FERMT3 309186  
FERMT3 83706 Q86UX7
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Top anti-FERMT3 Antikörper auf antikoerper-online.de

Showing 10 out of 75 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Ziege Unkonjugiert ELISA, WB Western Blot: FERMT3/URP2 Antibody [NBP1-51974] - Analysis of URP2 in Human Peripheral Blood Mononucleocytes lysate (35ug protein in RIPA buffer) using NBP1-51974 at 1ug/ml. Primary incubation was 1 hour. Detected bychemiluminescence. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$485.88
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
$507.83
Details
Fledermaus Ziege Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
$610.50
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Human Kaninchen Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$474.10
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Western Blot: URP2 Antibody [NBP2-20821] - Sample (30 ug of whole cell lysate) A: Jurkat B: Raji 7. 5% SDS PAGE gel, diluted at 1:1000. Immunohistochemistry-Paraffin: URP2 Antibody [NBP2-20821] - Immunohistochemical analysis of paraffin-embedded RT2 xenograft, using antibody at 1:500 dilution. 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$514.63
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Human Kaninchen Unkonjugiert ELISA, WB Western Blot: FERMT3/URP2 Antibody [NBP1-76349] - Rat spleen lysate with URP2 antibody at (A) 1 and (B) 2 ug/ml. Western Blot: FERMT3/URP2 Antibody  - Analysis of KINDLIN3 in rat spleen lysate with KINDLIN3 antibody at (A) 1 and (B) 2 ug/mL. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$485.88
Details
Human Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of various cells, using FERMT3 antibody. 100 μL Anmelden zum Anzeigen 16 Days
$334.77
Details
Human Kaninchen Unkonjugiert IHC (p), WB 50 μg Anmelden zum Anzeigen 12 bis 14 Tage
$685.40
Details
Human Ziege Unkonjugiert ELISA, WB FERMT3 polyclonal antibody  (1 ug/mL) staining of human peripheral blood mononucleocytes lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$374.13
Details

Am meisten referenzierte anti-FERMT3 Antikörper

  1. Human Polyclonal FERMT3 Primary Antibody für IF, WB - ABIN529478 : Feng, Li, Yau, Lee, Tang, Xue, Zhou, Lim, Cornvik, Ruedl, Shochat, Tan: Kindlin-3 mediates integrin ?L?2 outside-in signaling, and it interacts with scaffold protein receptor for activated-C kinase 1 (RACK1). in The Journal of biological chemistry 2012 (PubMed)

  2. Human Polyclonal FERMT3 Primary Antibody für ELISA, WB - ABIN4311346 : Svensson, Howarth, McDowall, Patzak, Evans, Ussar, Moser, Metin, Fried, Tomlinson, Hogg: Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. in Nature medicine 2009 (PubMed)

Weitere Antikörper gegen FERMT3 Interaktionspartner

Mouse (Murine) Fermitin Family Member 3 (FERMT3) Interaktionspartner

  1. Structure and lipid-binding properties of the kindlin-3 pleckstrin (zeige PLEK Antikörper) homology domain has been reported.

  2. Mice expressing as little as 5% of kindlin-3 were viable and protected from spontaneous bleeding and infections. In vitro platelet functions, leukocyte adhesion, extravasation, and bacterial clearance were diminished. Bleeding time increased.

  3. The accumulation of HSPCs in the circulation of leukocyte adhesion deficiency type III patients, who lack Kindlin-3, underlines the conserved functions of Kindlin-3 in man and the importance of our findings for human disease.

  4. Optimal T cell activation and B cell antibody responses in vivo require the interaction between Integrin beta2 and kindlin-3.

  5. Direct binding of kindlin-3 to integrin alphaIIbbeta3 is involved in supporting integrin alphaIIbbeta3 activation and integrin alphaIIbbeta3-dependent responses of platelets and consequently contributes significantly to arterial thrombus formation.

  6. ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.

  7. the requirement of Kindlin-3 for effector T cells to induce alpha4beta1 and alphaLbeta2 integrin ligand binding and stabilization of integrin-ligand bonds is critical when integrin ligand levels are low, but of less importance when integrin ligand levels are high.

  8. This is the first in vivo demonstration that Kindlin-3-stabilized integrin adhesions, although essential for lymphocyte arrest on blood vessels and interstitial motility, are not obligatory for leukocyte diapedesis.

  9. the beta-2-integrin-kindlin-3 interaction is particularly important in adhesion strengthening under shear flow, and for T-cell homing to lymph nodes, but dispensable for T cell activation which occurs in a shear-free environment

  10. Kindlin-3 is central to conversion of mechanical force to intracellular signaling via calcium influx.

Xenopus laevis Fermitin Family Member 3 (FERMT3) Interaktionspartner

Human Fermitin Family Member 3 (FERMT3) Interaktionspartner

  1. FERMT3 regulates glioma cell activity through integrin-mediated Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling.

  2. this case report describes a female Thai patient who was diagnosed with leukocyte adhesion deficiency type III with a novel mutation in FERMT3, presenting with a humoral immune defect

  3. kindlin-3 plays an important role in maintaining a proper conformation of the resting alpha4beta1 to mediate both rolling and firm cell adhesion

  4. Kindlin-3 regulates c-Myc (zeige MYC Antikörper) protein expression in the human chronic myeloid leukemia (zeige BCL11A Antikörper) cell line K562.

  5. NMR studies demonstrated that the F1 loop of kindlin-3 is globally unfolded but stretches of residues assuming transient helical conformations could be detected in aqueous solution.

  6. Suppression of the Kindlin-2 (zeige FERMT2 Antikörper)-integrin beta1-AKT (zeige AKT1 Antikörper) regulatory axis is an alternative mechanism underlying the tumor suppressor function of miR (zeige MLXIP Antikörper)-200b in esophageal squamous cell carcinoma.

  7. Kindlin-3/FERMT3 is upregulated in atherosclerotic, mainly in cells of monocytic origin and of M2 type. Simultaneous upregulation of ITGB2 (zeige ITGB2 Antikörper) suggests a synergistic effect on leukocyte adherence and transmigration into the vessel wall.

  8. The accumulation of HSPCs in the circulation of leukocyte adhesion deficiency type III patients, who lack Kindlin-3, underlines the conserved functions of Kindlin-3 in man and the importance of our findings for human disease.

  9. A new C>T point mutation was found in exon 13 in the FERMT3 gene in an infant diagnosed with LAD (zeige DLD Antikörper)-III. KINDLIN-3 expression is required for platelet aggregation and leukocyte function, but also osteoclast-mediated bone resorption.

  10. Mig-2 (zeige FERMT2 Antikörper) significantly attenuates the antitumor action of cisplatin.

FERMT3 Antigen-Profil

Protein Überblick

Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Genbezeichner und Symbole assoziert mit FERMT3

  • fermitin family member 3 (Fermt3) Antikörper
  • fermitin family member 3 L homeolog (fermt3.L) Antikörper
  • fermitin family member 3 (fermt3) Antikörper
  • fermitin family member 3 (FERMT3) Antikörper
  • fermitin family member 3b (fermt3b) Antikörper
  • C79673 Antikörper
  • KIND3 Antikörper
  • Kindlin3 Antikörper
  • MGC69069 Antikörper
  • MGC88900 Antikörper
  • MIG-2 Antikörper
  • MIG2B Antikörper
  • RGD1310168 Antikörper
  • UNC112C Antikörper
  • URP2 Antikörper
  • URP2SF Antikörper
  • zgc:64101 Antikörper

Bezeichner auf Proteinebene für FERMT3

fermitin family homolog 3 , unc-112-related protein 2 , fermitin family member 3 , MIG2-like protein , UNC-112 related protein 2 , kindlin 3 , kindlin-3

GENE ID SPEZIES
108101 Mus musculus
309186 Rattus norvegicus
379715 Xenopus laevis
448215 Xenopus (Silurana) tropicalis
483766 Canis lupus familiaris
100050011 Equus caballus
83706 Homo sapiens
525159 Bos taurus
393878 Danio rerio
Ausgewählte Anbieter für anti-FERMT3 (FERMT3) Antikörper
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