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Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit.
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FEM1 proteins are ancient regulators of Stem-Loop Binding Protein (zeige SLBP Proteine).
These findings have implications for understanding the cellular functions of Fem1b, and the regulation of Gli1 (zeige GLI1 Proteine) oncoprotein activity.
the proapoptotic protein Fem1b is downregulated by the proteasome in malignant colon cancer cells and mediates proteasome inhibitor-induced apoptosis of these cells
This study presents evidence suggesting a role for FEM1A (zeige FEM1A Proteine) and FEM1B in the pathogenesis of polycystic ovary syndrome. Only FEM1B variants were associated with insulin (zeige INS Proteine)-related traits in PCOS women.
FEM1B is required for Rad9 (zeige RAD9A Proteine) recruitment and CHK1 (zeige CHEK1 Proteine) activation in response to replication stress.
Fem1b is a binding partner of Ankrd37, and their interaction resulted in Ankrd37 degradation through the ubiquitin-mediated proteolysis pathway.
Increased Fem1b is associated with intestinal neoplasia.
neither FEM1B nor PHTF1 (zeige PHTF1 Proteine) are directly implicated in apoptosis in testis tissue
Fem1b is implicated in pancreatic islet function and insulin (zeige INS Proteine) secretion
Fem1b may have a conserved role in the generation of sexual dimorphism through its interaction with Nkx3.1 (zeige NKX3-1 Proteine) in the developing prostate gland
Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet (By similarity). Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 (By similarity).
FEM-1-like death receptor binding protein
, fem-1-like death receptor-binding protein alpha
, fem-1-like in apoptotic pathway protein alpha
, protein fem-1 homolog B
, feminization 1 homolog b
, fem-1 homolog b (C. elegans)