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FCGR2A encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells.
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Human FCGR2A Protein expressed in Human Cells - ABIN2002712
Stuart, Simister, Clarkson, Kacinski, Shapiro, Mellman: Human IgG Fc receptor (hFcRII, CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium. in The EMBO journal 1990
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alphaIIb beta3 antagonist TMV-7/trimucrin prevents thrombosis with causing Fc receptor gamma-chain IIa-mediated thrombocytopenia.
The expression levels of human FcgammaRIIB but not FcgammaRIIA were negatively correlated with serum levels of IgE in human asthma patients.
When higher-affinity genotypes for FCGR2A, FCGR3A (zeige CD16 Proteine), and FCGR2C were considered together, they were associated with significantly increased tumor shrinkage and prolonged survival in response to HD-IL2 (zeige IL2 Proteine)... this is the first study to show associations of FCGR genotypes with outcome following HD-IL2 (zeige IL2 Proteine) treatment
FcgammaRIIA and FcgammaRIIB both demonstrated increased methylation levels in Kawasaki disease (KD) patients that underwent IVIG treatment. FcgammaRIIA expression influenced the IVIG treatment response of KD patients. The FcgammaRIIA/IIB mRNA expression ratio was greater in KD patients with coronary artery lesion formation.
FCGR2A rs1801274 G-allele confers susceptibility to Kawasaki disease and Ulcerative colitis
farletuzumab has enhanced binding to FCGR3A-158V high-affinity receptor and has an enhanced clinical outcome in ovarian cancer patients with low baseline CA125 levels and at least 1 high-affinity allele of FCGR2A or FCGR3A
inhibition of Abl (zeige ABL1 Proteine)/Src (zeige SRC Proteine) with bosutinib reduced FcgammaRIIA-mediated glomerular neutrophil accumulation and renal injury in experimental, crescentic anti-GBM nephritis.
The present study demonstrates that p.His167Arg, a KD-associated FCGR2A variant, acts as a susceptibility gene in males only. Overall, the gender differences associated with FCGR2A in KD provide a new insight into KD susceptibility.
Data indicate a mechanism in which Toll (zeige TLR4 Proteine)-like receptors TLR7 (zeige TLR7 Proteine)/8 signaling, through shedding of FcgRIIA, shifts neutrophil function from phagocytosis to a programmed necrosis pathway, neutrophil extracellular trap formation (NETosis).
Gene copy number variation (CNV) of the PKLR (zeige PKLR Proteine), FCGR2A, FCGR2C, and FCGR3 (zeige CD16 Proteine) genes is associated with malaria severity, and our results provide evidence for a role of CNV in host responses to malaria.
This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants.
Immunoglobulin G Fc receptor II
, fc-gamma RII-a
, igG Fc receptor II-a
, low affinity immunoglobulin gamma Fc region receptor II-a
, Fc fragment of IgG, low affinity IIa, receptor for (CD32)
, Fc gamma receptor IIa