anti-Fanconi Anemia, Complementation Group D2 (FANCD2) Antikörper

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Zusätzlich bieten wir Ihnen FANCD2 Kits (9) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
FANCD2 2177 Q9BXW9
FANCD2 211651 Q80V62
FANCD2 312641 Q6IV68
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Top anti-FANCD2 Antikörper auf antikoerper-online.de

Showing 10 out of 169 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Hund Kaninchen Unkonjugiert FACS, ICC, IF, IHC, IHC (p), IP, RNAi, SimWes, WB FancD2 colocalizes in vivo with another protein in SiHa cells after cell exposure to IR. Proliferating SiHa cells were exposed to 10 Gy of IR and double -color immunofluorescence staining was performed after 8 h.  Images were captured in a Kodak digital image system on a Leica fluorescence microscope. FancD2 colocalizes in vivo with another protein in U2OS cells after cell exposure to IR. Proliferating U2OS cells were exposed to 10 Gy of IR and double -color immunofluorescence staining was performed after 8 h. Images were captured in a Kodak digital image system on a Leica fluorescence microscope. 0.05 mL Anmelden zum Anzeigen 7 bis 9 Tage
$514.63
Details
Hund Kaninchen Biotin ICC, IF, IHC, IHC (p), WB FancD2 colocalizes in vivo with another protein in SiHa cells after cell exposure to IR. Proliferating SiHa cells were exposed to 10 Gy of IR and double -color immunofluorescence staining was performed after 8 h. Images were captured in a Kodak digital image system on a Leica fluorescence microscope. FancD2 colocalizes in vivo with another protein in U2OS cells after cell exposure to IR. Proliferating U2OS cells were exposed to 10 Gy of IR and double -color immunofluorescence staining was performed after 8 h. Images were captured in a Kodak digital image system on a Leica fluorescence microscope. 0.05 mL Anmelden zum Anzeigen 7 bis 9 Tage
$626.75
Details
Hund Kaninchen HRP IHC, IHC (p), WB FancD2 colocalizes in vivo with another protein in SiHa cells after cell exposure to IR. Proliferating SiHa cells were exposed to 10 Gy of IR and double -color immunofluorescence staining was performed after 8 h. Images were captured in a Kodak digital image system on a Leica fluorescence microscope. FancD2 colocalizes in vivo with another protein in U2OS cells after cell exposure to IR. Proliferating U2OS cells were exposed to 10 Gy of IR and double -color immunofluorescence staining was performed after 8 h. Images were captured in a Kodak digital image system on a Leica fluorescence microscope. 0.05 mL Anmelden zum Anzeigen 7 bis 9 Tage
$655.50
Details
Human Maus Unkonjugiert ChIP, IP, SimWes, WB Simple Western: FANCD2 Antibody (FI-17) [ABIN151782] - Simple Western lane view shows a specific band for FANCD2 in 1.0 mg/ml of HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$444.19
Details
Pferd Kaninchen Unkonjugiert WB Host: Rabbit Target Name: FANCD2 Sample Type: NCI-H226 Whole Cell lysates Antibody Dilution: 1.0ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert WB Indicated lymphoblasts (PD7, WT: GM1526, AT) were irradiated with 15 Gy (2), and immunoblotted with anti-FANCD2 and anti-FANCD2 (pS-222), cat# ABIN151945. 0.2 mL Anmelden zum Anzeigen 7 bis 9 Tage
$415.44
Details
Human Kaninchen Unkonjugiert IF, IHC, WB Immunofluorescence analysis of A549 cell using FANCD2 antibody. 100 μL Anmelden zum Anzeigen 16 Days
$334.02
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from HT29 cells treated with Calyculin A 50ng/ml 30', using FANCD2 (Phospho-Ser222) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using FANCD2 (Phospho-Ser222) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from HT-29 cells, treated with Calyculin A 50ng/ml 30', using FANCD2 (Ab-222) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using FANCD2 (Ab-222) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert ELISA, IHC, IHC (p), WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$493.17
Details

FANCD2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-FANCD2 Antikörper

  1. Dog (Canine) Polyclonal FANCD2 Primary Antibody für FACS, ICC - ABIN151329 : Bekker-Jensen, Lukas, Kitagawa, Melander, Kastan, Bartek, Lukas: Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. in The Journal of cell biology 2006 (PubMed)
    Show all 131 Pubmed References

  2. Dog (Canine) Polyclonal FANCD2 Primary Antibody für ICC, IF - ABIN250520 : Garcia-Higuera, Taniguchi, Ganesan, Meyn, Timmers, Hejna, Grompe, DAndrea: Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. in Molecular cell 2001 (PubMed)
    Show all 15 Pubmed References

  3. Dog (Canine) Polyclonal FANCD2 Primary Antibody für IHC, IHC (p) - ABIN250521 : Rothfuss, Grompe: Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway. in Molecular and cellular biology 2003 (PubMed)
    Show all 15 Pubmed References

  4. Human Monoclonal FANCD2 Primary Antibody für ChIP, IP - ABIN151782 : Nomura, Adachi, Koyama: Human Mus81 and FANCB independently contribute to repair of DNA damage during replication. in Genes to cells : devoted to molecular & cellular mechanisms 2007 (PubMed)
    Show all 10 Pubmed References

  5. Human Polyclonal FANCD2 Primary Antibody für IHC - ABIN966127 : Kweekel, Antonini, Nortier, Punt, Gelderblom, Guchelaar: Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. in British journal of cancer 2009 (PubMed)
    Show all 6 Pubmed References

  6. Human Polyclonal FANCD2 Primary Antibody für WB - ABIN151945 : Taniguchi, Garcia-Higuera, Xu, Andreassen, Gregory, Kim, Lane, Kastan, DAndrea: Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. in Cell 2002 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen FANCD2 Interaktionspartner

Fruit Fly (Drosophila melanogaster) Fanconi Anemia, Complementation Group D2 (FANCD2) Interaktionspartner

  1. FANCD2 acts independently of previous S phases to promote alignment and segregation of acentric DNA produced by double-strand breaks.

  2. Fancd2 has a role in DNA repair.

Xenopus laevis Fanconi Anemia, Complementation Group D2 (FANCD2) Interaktionspartner

  1. study showed that FANCI (zeige FANCI Antikörper)-FANCD2 is required for replication-coupled DNA interstrand cross-link (ICL) repair in S phase; results show that multiple steps of the essential S-phase ICL repair mechanism fail when the Fanconi anemia (zeige PALB2 Antikörper) pathway is compromised

  2. The Fanconi anemia protein (zeige FANCF Antikörper) FANCM (zeige FANCM Antikörper) is controlled by FANCD2 and the ATR (zeige ATR Antikörper)/ATM (zeige ATM Antikörper) pathways.

Silk Worm Fanconi Anemia, Complementation Group D2 (FANCD2) Interaktionspartner

  1. silkworm cells deficient for FA proteins FancD2 and FancM (zeige FANCM Antikörper) exhibit normal sensitivities to hydroxyurea (HU) and camptothecin (CPT (zeige DHDDS Antikörper))

  2. It was shown that silkworm FancD2 is monoubiquitinated depending on FancI (zeige FANCI Antikörper) and FancL (zeige FANCL Antikörper), and stabilized on chromatin, following mitomycin C. Depletion of FancD2, FancI (zeige FANCI Antikörper) or FancL (zeige FANCL Antikörper) effected cell proliferation in the presence of mitomycin C.

Human Fanconi Anemia, Complementation Group D2 (FANCD2) Interaktionspartner

  1. demonstrate that the FANC pathway acts downstream MiTF (zeige MITF Antikörper) and establish the existence of an epistatic relationship between MiTF (zeige MITF Antikörper) and the FANC pathway

  2. we discuss the recent and relevant studies to provide an updated review on the roles of FANCD2 in the DNA damage response.

  3. FANCI (zeige FANCI Antikörper) phosphorylation activates the FANCI (zeige FANCI Antikörper)/D2 complex.

  4. FANCD2 and PALB2 (zeige PALB2 Antikörper), as indicators of the upstream and downstream arms, respectively, colocalize independently of each other in response to DNA damage.

  5. FANCD2 has a ubiquitination-independent role in countering endogenous levels of replication stress, a function that is critical for the maintenance of genomic stability.

  6. Data suggest that FANCI (zeige FANCI Antikörper) and FANCD2 have partially non-overlapping and possibly even opposing roles during the replication stress response.

  7. Fanconi anemia (zeige PALB2 Antikörper) FANCD2 and FANCI (zeige FANCI Antikörper) proteins regulate the nuclear dynamics of splicing factors, such as SF3B1 (zeige SF3B2 Antikörper).

  8. People with Fanconi anemia (zeige PALB2 Antikörper), or healthy people who develop sporadic mutations in FANCD2, may be hypersensitive to the carcinogenic activity of coffee.

  9. Results indicate the importance of DNA binding and nuclear localization sequences (NLS (zeige ALDH1A2 Antikörper)) residues in Fanconi Anemia Group D2 Protein (FANCD2) to activate an efficient Fanconi anemia (zeige PALB2 Antikörper) (FA) pathway.

  10. FANCB (zeige BRCA2 Antikörper) dimer coordinates FANCD2:FANCI (zeige FANCI Antikörper) monoubiquitination by two FANCL (zeige FANCL Antikörper) RING-ligases. Deubiquitination of FANCD2:FANCI (zeige FANCI Antikörper) by USP1 (zeige USP1 Antikörper):UAF1 (zeige WDR48 Antikörper) occurs only when DNA is removed.

Mouse (Murine) Fanconi Anemia, Complementation Group D2 (FANCD2) Interaktionspartner

  1. Data show that stromal cell lines derived from both K14E7 Fancd2-/- and Fancd2-/- cultures were radiosensitive.

  2. Fancd2-/- mice exhibit a pervasive developmental HSPC defect that echoes the constitutional defects evident at birth in a subset of FA patients.

  3. loss of Fancd2 yields significant defects to fetal liver hematopoiesis, particularly the HSC (zeige FUT1 Antikörper) population, which mimics key phenotypes from adult Fancd2 KO bone marrow independently of aging-accrued DNA damage.

  4. Data that suggest Usp1 (ubiquitin specific peptidase 1 (zeige USP1 Antikörper)) down-regulation by autocleavage is critical for Usp1 (zeige USP1 Antikörper) to exert role in DNA interstrand crosslink repair; Usp1 (zeige USP1 Antikörper) role is de-ubiquitination of Fancd2 and Pcna (proliferating cell nuclear antigen (zeige PCNA Antikörper)).

  5. recruitment of Fan1 (zeige FAN1 Antikörper) by ubiquitinated-Fancd2 is dispensable for DNA interstrand cross-links repair

  6. Results show that FANCD2 and ADH5 (zeige ADH5 Antikörper) protect hematopoietic stem cells, hepatocytes, and nephrons from endogenous DNA damage resulting from accumulation of endogenous formaldehyde.

  7. Combined deficiency of Foxo3a (zeige FOXO3 Antikörper) and Fancc (zeige FANCC Antikörper) or Fancd2 not only impairs the self-renewal capacity but also markedly increases the apoptosis of neural stem and progenitor cells (NSPCs), leading to defective neurogenesis.

  8. Data demonstrated that Fancd2 was required for nuclear retention of CA-FOXO3a (zeige FOXO3 Antikörper) and for maintaining hematopoietic repopulation of the HSCs.

  9. CD25 (zeige IL2RA Antikörper)(+)Foxp3 (zeige FOXP3 Antikörper)(+) Tregs of Fanca (zeige FANCA Antikörper)(-/-) or Fancd2(-/-) mice were less efficient in suppressing the production of GVHD-associated inflammatory cytokines.

  10. Fancd2-Ub activates the transcription of the tumor suppressor TAp63, thereby promoting cellular senescence and blocking skin tumorigenesis.

FANCD2 Antigen-Profil

Protein Überblick

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit FANCD2

  • Fanconi anemia complementation group D2 (FANCD2) Antikörper
  • CG17269 gene product from transcript CG17269-RA (Fancd2) Antikörper
  • Fanconi anemia group D2 protein (LOC100455970) Antikörper
  • Fanconi anemia complementation group D2 (fancd2) Antikörper
  • Fanconi anemia, complementation group D2 (fancd2) Antikörper
  • Fanconi anemia complementation group D2 L homeolog (fancd2.L) Antikörper
  • Fanconi anemia, complementation group D2 (FANCD2) Antikörper
  • Fanconi anemia, complementation group D2 (Fancd2) Antikörper
  • 2410150O07Rik Antikörper
  • AU015151 Antikörper
  • BB137857 Antikörper
  • CG17269 Antikörper
  • CG31192 Antikörper
  • CG31194 Antikörper
  • Dmel\\CG17269 Antikörper
  • dmFANCD2 Antikörper
  • FA-D2 Antikörper
  • FA4 Antikörper
  • FACD Antikörper
  • FAD Antikörper
  • FAD2 Antikörper
  • FANCD Antikörper
  • FANCD2 Antikörper
  • xfancd2 Antikörper

Bezeichner auf Proteinebene für FANCD2

Fanconi anemia, complementation group D2 , CG17269-PA , Fancd2-PA , Fanconi anemia group D2 protein-like , fanconi anemia protein FANCD2 , Fanconi anemia complementation group D2 , Fanconi anemia group D2 protein , Fanconi anemia group D2 protein homolog , Fanconi anemia D2 protein

GENE ID SPEZIES
460163 Pan troglodytes
2768674 Drosophila melanogaster
100024226 Monodelphis domestica
100051871 Equus caballus
100455970 Pongo abelii
100469116 Ailuropoda melanoleuca
100487938 Xenopus (Silurana) tropicalis
100546871 Meleagris gallopavo
100560437 Anolis carolinensis
394241 Danio rerio
415935 Gallus gallus
734196 Xenopus laevis
100346581 Oryctolagus cuniculus
100620065 Bombyx mori
2177 Homo sapiens
211651 Mus musculus
312641 Rattus norvegicus
484659 Canis lupus familiaris
100522343 Sus scrofa
515845 Bos taurus
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