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The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Zusätzlich bieten wir Ihnen FANCD2 Kits (8) und und viele weitere Produktgruppen zu diesem Protein an.
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Dog (Canine) Polyclonal FANCD2 Primary Antibody für FACS, ICC - ABIN151329
Bekker-Jensen, Lukas, Kitagawa, Melander, Kastan, Bartek, Lukas: Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. in The Journal of cell biology 2006
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Dog (Canine) Polyclonal FANCD2 Primary Antibody für ICC, IF - ABIN250520
Garcia-Higuera, Taniguchi, Ganesan, Meyn, Timmers, Hejna, Grompe, DAndrea: Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. in Molecular cell 2001
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Dog (Canine) Polyclonal FANCD2 Primary Antibody für IHC, IHC (p) - ABIN250521
Rothfuss, Grompe: Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway. in Molecular and cellular biology 2003
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Human Monoclonal FANCD2 Primary Antibody für ChIP, IP - ABIN151782
Nomura, Adachi, Koyama: Human Mus81 and FANCB independently contribute to repair of DNA damage during replication. in Genes to cells : devoted to molecular & cellular mechanisms 2007
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Human Polyclonal FANCD2 Primary Antibody für IHC - ABIN966127
Kweekel, Antonini, Nortier, Punt, Gelderblom, Guchelaar: Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. in British journal of cancer 2009
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Human Polyclonal FANCD2 Primary Antibody für WB - ABIN151945
Taniguchi, Garcia-Higuera, Xu, Andreassen, Gregory, Kim, Lane, Kastan, DAndrea: Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. in Cell 2002
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FANCD2 acts independently of previous S phases to promote alignment and segregation of acentric DNA produced by double-strand breaks.
Fancd2 has a role in DNA repair.
study showed that FANCI (zeige FANCI Antikörper)-FANCD2 is required for replication-coupled DNA interstrand cross-link (ICL) repair in S phase; results show that multiple steps of the essential S-phase ICL repair mechanism fail when the Fanconi anemia (zeige PALB2 Antikörper) pathway is compromised
The Fanconi anemia protein (zeige FANCF Antikörper) FANCM (zeige FANCM Antikörper) is controlled by FANCD2 and the ATR (zeige ATR Antikörper)/ATM (zeige ATM Antikörper) pathways.
silkworm cells deficient for FA proteins FancD2 and FancM (zeige FANCM Antikörper) exhibit normal sensitivities to hydroxyurea (HU) and camptothecin (CPT (zeige DHDDS Antikörper))
It was shown that silkworm FancD2 is monoubiquitinated depending on FancI (zeige FANCI Antikörper) and FancL (zeige FANCL Antikörper), and stabilized on chromatin, following mitomycin C. Depletion of FancD2, FancI (zeige FANCI Antikörper) or FancL (zeige FANCL Antikörper) effected cell proliferation in the presence of mitomycin C.
FANCD2 and PALB2 (zeige PALB2 Antikörper), as indicators of the upstream and downstream arms, respectively, colocalize independently of each other in response to DNA damage.
FANCD2 has a ubiquitination-independent role in countering endogenous levels of replication stress, a function that is critical for the maintenance of genomic stability.
Data suggest that FANCI (zeige FANCI Antikörper) and FANCD2 have partially non-overlapping and possibly even opposing roles during the replication stress response.
Fanconi anemia (zeige PALB2 Antikörper) FANCD2 and FANCI (zeige FANCI Antikörper) proteins regulate the nuclear dynamics of splicing factors, such as SF3B1 (zeige SF3B2 Antikörper).
People with Fanconi anemia (zeige PALB2 Antikörper), or healthy people who develop sporadic mutations in FANCD2, may be hypersensitive to the carcinogenic activity of coffee.
Results indicate the importance of DNA binding and nuclear localization sequences (NLS (zeige ALDH1A2 Antikörper)) residues in Fanconi Anemia Group D2 Protein (FANCD2) to activate an efficient Fanconi anemia (zeige PALB2 Antikörper) (FA) pathway.
FANCB (zeige BRCA2 Antikörper) dimer coordinates FANCD2:FANCI (zeige FANCI Antikörper) monoubiquitination by two FANCL (zeige FANCL Antikörper) RING-ligases. Deubiquitination of FANCD2:FANCI (zeige FANCI Antikörper) by USP1 (zeige USP1 Antikörper):UAF1 (zeige WDR48 Antikörper) occurs only when DNA is removed.
These results reveal a synthetic lethal relationship between FANCD2 and BRCA1/2.
these findings provide a previously unrecognized central player FANCD2-V2 and thus novel insights into human tumorigenesis, and indicate that V2/V1 can act as an effective biomarker in assisting the recognition of tumor malignance
The data demonstrate that FANCD2 protein is required to ensure efficient chromosome fragile sites (CFS) replication and provide mechanistic insight into how FANCD2 regulates CFS stability.
Data show that stromal cell lines derived from both K14E7 Fancd2-/- and Fancd2-/- cultures were radiosensitive.
Fancd2-/- mice exhibit a pervasive developmental HSPC defect that echoes the constitutional defects evident at birth in a subset of FA patients.
loss of Fancd2 yields significant defects to fetal liver hematopoiesis, particularly the HSC (zeige FUT1 Antikörper) population, which mimics key phenotypes from adult Fancd2 KO bone marrow independently of aging-accrued DNA damage.
Data that suggest Usp1 (ubiquitin specific peptidase 1 (zeige USP1 Antikörper)) down-regulation by autocleavage is critical for Usp1 (zeige USP1 Antikörper) to exert role in DNA interstrand crosslink repair; Usp1 (zeige USP1 Antikörper) role is de-ubiquitination of Fancd2 and Pcna (proliferating cell nuclear antigen (zeige PCNA Antikörper)).
recruitment of Fan1 (zeige FAN1 Antikörper) by ubiquitinated-Fancd2 is dispensable for DNA interstrand cross-links repair
Results show that FANCD2 and ADH5 (zeige ADH5 Antikörper) protect hematopoietic stem cells, hepatocytes, and nephrons from endogenous DNA damage resulting from accumulation of endogenous formaldehyde.
Combined deficiency of Foxo3a (zeige FOXO3 Antikörper) and Fancc (zeige FANCC Antikörper) or Fancd2 not only impairs the self-renewal capacity but also markedly increases the apoptosis of neural stem and progenitor cells (NSPCs), leading to defective neurogenesis.
Data demonstrated that Fancd2 was required for nuclear retention of CA-FOXO3a (zeige FOXO3 Antikörper) and for maintaining hematopoietic repopulation of the HSCs.
CD25 (zeige IL2RA Antikörper)(+)Foxp3 (zeige FOXP3 Antikörper)(+) Tregs of Fanca (zeige FANCA Antikörper)(-/-) or Fancd2(-/-) mice were less efficient in suppressing the production of GVHD-associated inflammatory cytokines.
Fancd2-Ub activates the transcription of the tumor suppressor TAp63, thereby promoting cellular senescence and blocking skin tumorigenesis.
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms.
Fanconi anemia, complementation group D2
, Fanconi anemia group D2 protein-like
, fanconi anemia protein FANCD2
, Fanconi anemia complementation group D2
, Fanconi anemia group D2 protein
, Fanconi anemia group D2 protein homolog
, Fanconi anemia D2 protein