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FYCO1 encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain.
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FYCO1 and MAP1LC3A (zeige MAP1LC3A ELISA Kits) interact through a novel binding mode that involves Atg8 (zeige GABARAPL2 ELISA Kits)-family proteins
Rare missense variants in FYCO1 are overrepresented in sporadic inclusion body myositis patients.
FYCO1 requires a functional LC3A (zeige MAP1LC3A ELISA Kits)/B-preferring LC3 (zeige MAP1LC3A ELISA Kits)-interacting Region (LIR (zeige CD300C ELISA Kits)) motif to facilitate efficient maturation of autophagosomes under basal conditions, whereas starvation-induced autophagy was unaffected
FYCO1 is involved in lens development and transparency in humans, and mutations in this gene are one of the most common causes of autosomal-recessive congenital cataracts in the Pakistani population.
We have characterized the LC3 (zeige MAP1LC3A ELISA Kits)-, Rab7-, and phosphatidylinositol-3-phosphate-binding domains in FYCO1 and mapped part of the CC region essential for MT plus end-directed transport.
Ribonucleoprotein (zeige RBP31 ELISA Kits) granule homeostasis is regulated by FYCO1-mediated autophagy.
The crystal structure of mouse LC3B (zeige MAP1LC3B ELISA Kits) in complex with the FYCO1 LC3 (zeige MAP1LC3A ELISA Kits)-interacting region (LIR (zeige CD300C ELISA Kits)) reveals the importance of the flanking region of the LIR (zeige CD300C ELISA Kits) motif.
FYVE and coiled-coil domain containing 1 (FYCO1), a protein previously implicated in autophagosome trafficking, is recruited directly by LC3 (zeige MAP1LC3A ELISA Kits) to Dectin-1 (zeige CLEC7A ELISA Kits) phagosomes.
This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2).
FYVE and coiled-coil domain-containing protein 1
, FYVE and coiled-coil domain containing 1
, FYVE and coiled-coil domain-containing protein 1-like
, RUN and FYVE domain containing 3
, zinc finger FYVE domain-containing protein 7
, maternal embryonic message 2