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FEV belongs to the ETS transcription factor family.
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This study adds to the growing evidence on the association of single- and multiple-risk variants in DRD3 (zeige DRD3 Antikörper), DRD4 (zeige DRD4 Antikörper), and FEV with aggressive behavior in Chinese adolescents.
identified FEV is unique to fetal HSCs and stably expressed in leukemic cells of prenatal origin
novel evidence for the role of Pet-1 in human amygdala threat processing extends literature demonstrating the influence of genetic variation in the serotonin system on emotional regulation
Fev-ERK signaling is essential for hemogenic endothelium-based hematopoietic stem cell development.
our data argue against an exclusive role of FEV in the adult human brain serotonergic system and genetic analyses did not suggest that FEV variation adds to the genetic liability towards affective disorders
FEV identifies serotonin-producing cells in normal and neoplastic small intestine.
Serotonin-related FEV gene variant in the sudden infant death syndrome is a common polymorphism in the African-American population.
FEV acts as a transcriptional repressor through its DNA-binding ETS (zeige ETS1 Antikörper) domain and alanine-rich domain.
We showed that fev is exclusively expressed in the midline part of the human brainstem containing raphe nuclei, which also specifically expressed 5-HT (zeige DDC Antikörper) transporter (sert (zeige SLC6A4 Antikörper)) and tryptophan hydroxylase (tph (zeige TPH1 Antikörper)), two markers of the 5-HT (zeige DDC Antikörper) neurotransmitter system.
Analysis of transgene expression in Pet-1 null mice indicates that Pet-1 is required to maintain the activity of the Pet-1 enhancer region in a subset of serotonin (5-HT (zeige DDC Antikörper)) neurons.
These results suggest a causal relationship between 5-HT1A (zeige HTR1A Antikörper) and Pet1, and reveal a potential mechanism by which 5-HT1A (zeige HTR1A Antikörper)-Pet1 autoregulatory loop is maintained by serotonin.
novel evidence for the role of Pet-1 in fear processing and dendritic organization of amygdala neurons
Pet1-dependent and Pet1-resistant 5-serotonin (5-HT (zeige DDC Antikörper)) neurons target different brain centers that might delineate the anatomical basis for a dual serotonergic control on stress responses.
The data of this study indicated that, in addition to transcriptional regulation by Pet-1 in raphe neurons, 5-HT1A receptor (zeige CC2D1A Antikörper) expression is regulated indirectly by alterations in 5-HT (zeige DDC Antikörper) neurotransmission in a region-specific manner
This study indicated that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription.
Pet-1(-/-) neonates are probably not hypoxic from respiratory dysfunction until P14 (zeige PCOLCE Antikörper)-15; neither apnea-related hypoxia nor greater hypopnea contribute to the enhanced bradycardias of Pet-1 and there may be enhanced temperature reflex in hyperthermia
expressed in central serotonergic (5-hydroxytryptaminergic) neurons located in the mes (zeige PTCH1 Antikörper)-/metencephalic raphe nuclei from E11 (zeige PDPN Antikörper) on until adulthood
Pet-1 is a critical determinant of 5-HT (zeige DDC Antikörper) neuron identity and Pet-1-dependent program is involved in serotonergic modulation of behavior
Ectopic expression of Lmx1b (zeige LMX1B Antikörper) plus Pet-1 is able to induce formation of 5-HT (zeige DDC Antikörper) cells in the most ventral spinal cord, where Nkx2.2 (zeige Nkx2-2 Antikörper) is normally expressed. Combined expression of Lmx1b (zeige LMX1B Antikörper), Pet-1, and Nkx2.2 (zeige Nkx2-2 Antikörper), drives 5-HT (zeige DDC Antikörper) differentiation in the dorsal spinal cord
Our findings identify a direct transcriptional interaction between Gata-2 (zeige GATA2 Antikörper) and FEV and a unique marker for new insight into FEV/Pet-1 function in 5-HT (zeige DDC Antikörper) neuron development.
Spatiotemporal expression profile of the Ets-domain transcription factor-encoding gene pet1 in developing and adult zebrafish.
This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations.
, FEV (ETS oncogene family)
, PC12 ETS domain-containing transcription factor 1
, fifth Ewing variant protein
, ETS-domain transcription factor Pet-1
, FEV (fifth Ewing variant)
, PC12 ETS factor 1
, pheochromocytoma 12 ETS (E26 transformation-specific)
, ETS domain transcription factor Pet-1
, ETS domain transcription factor
, protein Pet-1