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Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. Zusätzlich bieten wir Ihnen FBXL18 Antikörper (28) und FBXL18 Kits (13) und viele weitere Produktgruppen zu diesem Protein an.
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Study showed that LRRK2 phosphorylation is required for LRRK2 to bind to Fbxl18, and that this interaction is important for regulating the amount of LRRK2 via ubiquitination of LRRK2 by the SCFFbxl18 ubiquitin ligase and subsequent proteasomal degradation of LRRK2. We also show that LRRK2 can induce caspase 8 mediated cell death and that the degradation of LRRK2 mediated by Fbxl18 can prevent LRRK2-mediated toxicity.
FBXL18 plays an oncogenic role through promoting lysine 63-linked ubiquitination of Akt in glioma.
Fbxl18 regulates apoptosis by mediating ubiquitin-dependent proteasomal degradation of the pro-apoptotic protein Fbxl7 that may impact cellular processes involved in cell cycle progression.
Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1\\\\; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004
F-box/LRR-repeat protein 18
, F-box and leucine-rich repeat protein 18
, f-box/LRR-repeat protein 18-like