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Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. Zusätzlich bieten wir Ihnen F-Box Protein 28 Antikörper (37) und F-Box Protein 28 Kits (13) und viele weitere Produktgruppen zu diesem Protein an.
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It was shown on human primary islets that FBXO28 improves pancreatic beta-cell survival under diabetogenic conditions without affecting insulin (zeige INS Proteine) secretion.
Expression levels of TP53BP2 (zeige TP53BP2 Proteine), FBXO28, and FAM53A (zeige Fam53a Proteine) genes were associated with patient survival specifically in ER-positive, TP53 (zeige TP53 Proteine)-mutated tumors.
Fbxo28 regulates topoisomerase IIalpha decatenation activity and plays an important role in maintaining genomic stability.
Refinement of the critical region of 1q41q42 microdeletion syndrome identifies FBXO28 as a candidate causative gene for intellectual disability and seizures.
Study identified F-box protein, FBXO28 that controls MYC (zeige MYC Proteine)-dependent transcription by non-proteolytic ubiquitylation. Depletion of FBXO28 or overexpression of an F-box mutant unable to support MYC (zeige MYC Proteine) ubiquitylation results in an impairment of MYC (zeige MYC Proteine)-driven transcription, transformation and tumourigenesis.
Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1\; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004
F-box protein 28
, F-box only protein 28
, centromere protein 30