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DNA helicase that acts as an essential component of the spindle assembly checkpoint. Zusätzlich bieten wir Ihnen Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6-Like Proteine (3) und und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal ERCC6L Primary Antibody für WB - ABIN527207
Laulier, Cheng, Stark: The relative efficiency of homology-directed repair has distinct effects on proper anaphase chromosome separation. in Nucleic acids research 2011
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Human Monoclonal ERCC6L Primary Antibody für ELISA, WB - ABIN565778
Leng, Bessuso, Jung, Wang, Qin: Targeting Plk1 to chromosome arms and regulating chromosome compaction by the PICH ATPase. in Cell cycle (Georgetown, Tex.) 2008
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Human Polyclonal ERCC6L Primary Antibody für WB - ABIN527205
Nera, Huang, Lai, Xu: Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions. in Nature communications 2015
ERCC6L may stimulates cancer cell proliferation by promoting cell cycle through a way of RAB31 (zeige RAB31 Antikörper)-MAPK (zeige MAPK1 Antikörper)-CDK2 (zeige CDK2 Antikörper), and it could be a potential biomarker for cancer prognosis and target for cancer treatment.
Data indicate BEND3 as a new interaction partner for PICH in mitosis, and have defined the residues within a TPR-BEN domain interface that mediate this interaction.
Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex has been reported.
a novel SUMO-dependent regulation of PICH's function on mitotic centromeres, is reported.
PICH and Topo II (zeige TOP2 Antikörper) cooperate to prevent chromosome missegregation events in mitosis.
PICH is a SUMO-interacting protein and a mitotic SUMO substrate.
PICH binds to BLM (zeige BLM Antikörper) and enables BLM (zeige BLM Antikörper) localization to anaphase centromeric threads. PICH and BLM (zeige BLM Antikörper) unravel centromeric chromatin and keep anaphase DNA threads mostly free of nucleosomes.
the PICH-Plk1 complex plays a critical role in maintaining prometaphase chromosome architecture
the spindle checkpoint failure formerly attributed to the depletion of PICH most likely reflects an off-target effect that causes the lowering of Mad2 (zeige MAD2L1 Antikörper) transcript and protein.
PICH phosphorylation and its ATPase activity are required for mitotic chromosome compaction through the targeting of Plk1 to chromosome arms.
DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase.
ATP-dependent helicase ERCC6-like
, DNA excision repair protein ERCC-6-like
, Plk1-interacting checkpoint helicase
, SNF2/RAD54 family protein
, excision repair cross-complementing rodent repair deficiency complementation group 6 - like
, excision repair protein ERCC6-like
, tumor antigen BJ-HCC-15
, excision repair cross-complementing rodent repair deficiency complementation group 6-like
, excision repair cross-complementing rodent repair deficiency, complementation group 6-like