anti-Eukaryotic Translation Initiation Factor 4E (EIF4E) Antikörper

The protein encoded by EIF4E is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. Zusätzlich bieten wir Ihnen EIF4E Proteine (16) und EIF4E Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
EIF4E 1977 P06730
EIF4E 13684 P63073
EIF4E 117045 P63074
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top anti-EIF4E Antikörper auf antikoerper-online.de

Showing 10 out of 257 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IF (cc), IF (p), IHC (p), WB 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$306.90
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB <b>WB Suggested Anti-EIF4E Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Human brain <b>Sample Type:</b> Lane1 = 10ug HEK293 lysate<br>Lane 2 = 50ug HEK293 lysate<br><b>Primary Antibody Dilution:</b> Anti-EIF4E 1:1000<br><b>Submitted By</b>: Dr. Veronique Dorval, Laval University 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-Eif4e AntibodyTitration: 1.0 µg/mL <br /> Positive Control: Rat Liver 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Huhn Maus Unkonjugiert BI, WB Western blot analysis of eIF-4E on a A431 lysate. Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of the eIF-4E antibody. Immunofluorescent staining of U-2 OS (ATCC HTB-96) cells. Cells were seeded in a 96 well imaging plate at ~ 10 000 cells per well. After overnight incubation, cells were stained using the alcohol perm protocol and the anti-eIF-4E antibody. The second step reagent was Alexa Fluor 488 goat anti mouse Ig (Invitrogen). Images were taken on a BD Pathway™ 855 Bioimager using a 20x objective. This antibody also stained A549 (ATCC CCL-185) and HeLa (ATCC CCL-2) cells. The Triton™ X-100 perm protocol is not recommended for use with this antibody. 150 μg Anmelden zum Anzeigen 6 bis 8 Tage
$305.54
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunohistochemistry: eIF4E [p Ser209] Antibody [ABIN43076388] - Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using elF4E (phospho-Ser209) antibody Western Blot: eIF4E [p Ser209] Antibody [ABIN43076388] - Analysis of extract from NIH/3T3 cells untreated or treated with 10% serum (15min), using elF4E (Ab-209) antibody ( Line 1 and 2) and elF4E (phospho-Ser209) antibody (Line 3 and 4). 0.05 mL Anmelden zum Anzeigen 12 bis 15 Tage
$415.44
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-EIF4E Antibody (N-term) Pab (ABIN388675) in HL60 cell line lysates. EIF4E Antibody (N-term)(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human breast carcinoma reacted with EIF4E antibody (N-term)(ABIN388675), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB Immunohistochemical analysis of EIF4E staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of EIF4E expression in HEK293T (A), NIH3T3 (B) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert DB Dot blot analysis of anti-EIF4E-pS209 Phospho-specific Pab (ABIN389859) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from NIH-3T3 cells, treated with FBS, using eIF4E (Ab-209) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using eIF4E (Ab-209) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from 293 cells treated with Anisomycin 25ug/ml 30', using eIF4E (Phospho-Ser209) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using eIF4E (Phospho-Ser209) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details

EIF4E Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human , , , ,
,
,
, , , , , , , , , , , , , , , ,
Mouse (Murine) ,
,
,
, , , , , , , , , , , , ,
Rat (Rattus) ,
,
,
, , , , , , , , , , , , ,

Am meisten referenzierte anti-EIF4E Antikörper

  1. Chicken Monoclonal EIF4E Primary Antibody für BI, WB - ABIN967870 : De Benedetti, Rhoads: Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology. in Proceedings of the National Academy of Sciences of the United States of America 1990 (PubMed)
    Show all 5 Pubmed References

  2. Chicken Monoclonal EIF4E Primary Antibody für BI, WB - ABIN967869 : Jiang, Ballou, Lin: Rapamycin-insensitive regulation of 4e-BP1 in regenerating rat liver. in The Journal of biological chemistry 2001 (PubMed)
    Show all 5 Pubmed References

  3. Human Monoclonal EIF4E Primary Antibody für FACS, WB - ABIN659031 : Hoeffer, Cowansage, Arnold, Banko, Moerke, Rodriguez, Schmidt, Klosi, Chorev, Lloyd, Pierre, Wagner, LeDoux, Klann: Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation. in Proceedings of the National Academy of Sciences of the United States of America 2011 (PubMed)
    Show all 3 Pubmed References

  4. Human Monoclonal EIF4E Primary Antibody für ICC, FACS - ABIN969094 : Slepenkov, Korneeva, Rhoads: Kinetic mechanism for assembly of the m7GpppG.eIF4E.eIF4G complex. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 Pubmed References

  5. Human Monoclonal EIF4E Primary Antibody für FACS, IF - ABIN966052 : Holm, Byrnes, Johnson, Abreo, Sehon, Alley, Meschonat, Md, Li: A prospective trial on initiation factor 4E (eIF4E) overexpression and cancer recurrence in node-negative breast cancer. in Annals of surgical oncology 2008 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal EIF4E Primary Antibody für ICC, IF - ABIN4307638 : Chen, Zhu, McCauley, Zhao, Johnson, Rhoads, El-Kadi: Diminished satellite cell fusion and S6K1 expression in myotubes derived from skeletal muscle of low birth weight neonatal pigs. in Physiological reports 2017 (PubMed)

  7. Human Monoclonal EIF4E Primary Antibody für IF, WB - ABIN659032 : Hoeffer, Santini, Ma, Arnold, Whelan, Wong, Pierre, Pelletier, Klann: Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation. in Journal of neurophysiology 2013 (PubMed)

Weitere Antikörper gegen EIF4E Interaktionspartner

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 4E (EIF4E) Interaktionspartner

  1. The structures of eIF4E-eIF4G (zeige EIF4G1 Antikörper) complexes reveal an extended interface to regulate translation initiation.

  2. Phosphorylation of 4E-BP1 (zeige EIF4EBP1 Antikörper) impairs the competition with eIF4G (zeige EIF4G1 Antikörper) for eIF4E binding.

  3. Both eIF4E-1 and eIF4E-3 (zeige EIF4E3 Antikörper) are required in spermatocytes for chromosome condensation and cytokinesis during the meiotic stages.

  4. eIF4E-binding protein (zeige EIF4EBP1 Antikörper) requires non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.

  5. Protein-protein interactions rather than interactions with the mRNA are essential for the recruitment of eIF4E and for a putative nucleation function.

  6. Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.

  7. eIF4E regulates the sex-specific expression of the master switch gene Sxl.

  8. data are consistent with the idea that Parkin (zeige PARK2 Antikörper) and eIF4E act in a common pathway, likely modulating cap-dependent translation initiation events.

  9. results show that LK6 binds to ERK (zeige MAPK1 Antikörper) and is activated by ERK (zeige MAPK1 Antikörper) signalling and it is responsible for phosphorylating eIF4E in Drosophila

  10. our results suggest that the level of eIF4E protein is regulated by Diap1 (zeige DIAPH1 Antikörper), and that IAPs may play a role in cap-dependent translation by regulating the level of eIF4E protein.

Xenopus laevis Eukaryotic Translation Initiation Factor 4E (EIF4E) Interaktionspartner

  1. Pumilio 2 (zeige PUM2 Antikörper) controls translation by competing with eIF4E for 7-methyl guanosine cap recognition.

  2. CDK1 (zeige CDK1 Antikörper) and calcineurin regulate Maskin (zeige TACC3 Antikörper) association with eIF4E and translational control of cell cycle progression

  3. CPEB, partnered with several highly conserved RNA-binding partners, inhibits protein synthesis in oocytes using a novel pairing of 4E-T (zeige EIF4ENIF1 Antikörper) and eIF4E1b (zeige EIF4E1B Antikörper)

Human Eukaryotic Translation Initiation Factor 4E (EIF4E) Interaktionspartner

  1. Our results indicate that AURKA (zeige AURKA Antikörper) plays an important role in the activation of EIF4E and cap-dependent translation. Targeting the AURKA (zeige AURKA Antikörper)-EIF4E-c-MYC (zeige MYC Antikörper) axis using alisertib is a novel therapeutic strategy that can be applicable for everolimus-resistant tumors and/or subgroups of cancers that show overexpression of AURKA (zeige AURKA Antikörper) and activation of EIF4E and c-MYC (zeige MYC Antikörper)

  2. Treatment with 240 mg/l matrine reduced the protein expression levels of PCNA (zeige PCNA Antikörper) and eIF4E. Matrine also reduced the migration ability of A549 cells and inhibited their proliferation, which may be associated with the overexpression of p53 (zeige TP53 Antikörper) and p21 (zeige CDKN1A Antikörper), and the reduction of PCNA (zeige PCNA Antikörper) and eIF4E expression levels.

  3. eIF4E and MMP9 (zeige MMP9 Antikörper) expression in endometrial cancer specimens suggests their potential up-regulation during carcinogenesis.

  4. eIF4E promoted cholangiocarcinoma cell metastasis by up-regulating the expression of VEGF-C (zeige VEGFC Antikörper), MMP-2 (zeige MMP2 Antikörper) and suppressing E-cadherin (zeige CDH1 Antikörper) expression.

  5. Translational initiation pathway inhibition could be of clinical utility in male breast cancer patients overexpressing eIF4E and eIF5 (zeige EIF5 Antikörper). With mTOR (zeige FRAP1 Antikörper) inhibitors that target this pathway now in the clinic, these biomarkers may represent new targets for therapeutic intervention, although further independent validation is required

  6. Data show association of eIF4E expression with chemotherapeutic response in esophageal squamous cell carcinoma (ESCC), and suggest that therapeutically targeting eIF4E may be a viable means of improving chemotherapy response in ESCC.

  7. We performed bioinformatics analyses of ESTs and the 3'UTRs of the main transcript splice variants of the translational initiation factor eIF4E1 and its family members, eIF4E2 (zeige EIF4E2 Antikörper) and eIF4E3 (zeige EIF4E3 Antikörper). We propose to elucidate the minor splice variants of eIF4E2 (zeige EIF4E2 Antikörper) and eIF4E3 (zeige EIF4E3 Antikörper) in great detail because they might produce proteins with modified features that fulfill different cellular roles from their major counterparts.

  8. EIF4E associated signaling pathways are associated with lymphangiogenesis and lymph node metastases of hypopharyngeal cancer.

  9. The authors show that LARP1 directly binds the cap and adjacent 5'TOP motif of TOP mRNAs, effectively impeding access of eIF4E to the cap and preventing eIF4F (zeige EIF4A2 Antikörper) assembly. Thus, LARP1 is a specialized TOP mRNA cap-binding protein that controls ribosome biogenesis.

  10. Mitogen-activated protein kinase (zeige MAPK1 Antikörper) interacting protein (zeige CIB1 Antikörper) kinases (Mnks) control translation by phosphorylation of eIF4E, whereas the mTOR (zeige FRAP1 Antikörper) kinase phosphorylates/de-activates the eIF4E inhibitor, 4E-BP1 (zeige EIF4EBP1 Antikörper), to release translational repression.

Mouse (Murine) Eukaryotic Translation Initiation Factor 4E (EIF4E) Interaktionspartner

  1. Lack of Def6 (zeige DEF6 Antikörper) results in deregulation of Bcl6 (zeige BCL6 Antikörper) protein synthesis in T cells as a result of enhanced activation of the mTORC1-4E-BP-eIF4E axis.

  2. Mitogen-activated protein kinase (zeige MAPK1 Antikörper) interacting protein (zeige CIB1 Antikörper) kinases (Mnks) control translation by phosphorylation of eIF4E, whereas the mTOR (zeige FRAP1 Antikörper) kinase phosphorylates/de-activates the eIF4E inhibitor, 4E-BP1 (zeige EIF4EBP1 Antikörper), to release translational repression.

  3. PRMT1 (zeige PRMT1 Antikörper) inhibition prevents gastric cancer progression by downregulating eIF4E and targeting type II PRMT5 (zeige PRMT5 Antikörper).

  4. Our work demonstrates that a single phosphorylation site on the 5' cap-binding protein eIF4E is a critical mechanism for changes in nociceptor excitability that drive the development of chronic pain.

  5. data suggest a physiological role for MNK1a-Ser (zeige SIGLEC1 Antikörper)(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E phosphorylation in vitro and in vivo.

  6. Results of our study suggest that the eIF4E/Fmr1 (zeige FMR1 Antikörper) double mutant mouse may be a reliable model to study cognitive dysfunction in the context of autism spectrum disorder.

  7. Our findings identify the eIF4E- beta-catenin (zeige CTNNB1 Antikörper) axis as a critical regulator of lung cancer cell growth and survival, and suggest that its pharmacological inhibition may be therapeutically useful in lung cancer.

  8. Unphosphorylated HSP27 (zeige HSPB1 Antikörper) associates with eIF4E in osteoblasts and suppresses the translation initiation process.

  9. Rotenone induction of hydrogen peroxide inhibits mTOR (zeige FRAP1 Antikörper)-mediated S6K1 (zeige RPS6KB1 Antikörper) and 4E-BP1 (zeige EIF4EBP1 Antikörper)/eIF4E pathways, resulting in caspase (zeige CASP3 Antikörper)-dependent and -independent apoptosis in neuronal cells.

  10. Findings indicate eIF4E is maintained at levels in excess (zeige RCC1 Antikörper) for normal development that are hijacked by cancer cells to drive a translational program supporting tumorigenesis.

Pig (Porcine) Eukaryotic Translation Initiation Factor 4E (EIF4E) Interaktionspartner

  1. These data suggest that sapovirus VPg can hijack the cellular translation initiation mechanism by recruiting the eIF4F (zeige EIF4A2 Antikörper) complex through a direct eIF4E interaction

  2. it is proposed that a balanced regulation of the truncation of the cap-binding complex component eIF4F (zeige EIF4A2 Antikörper) and degradation of 4E-BP1 (zeige EIF4EBP1 Antikörper) and/or truncation of 4E-BP2 (zeige EIF4EBP2 Antikörper) that together ensures correct translational control during the dynamic process of conceptus implantation

  3. Results show that in pigs, the truncated eIF4E is located in the endometrial luminal epithelium during implantation. Neither glandulary tissue nor stroma expressed any truncated eIF4E.

  4. The translation initiation in the endometrium is differently regulated by the two eIF4E forms with regard to different 4E-BP1 (zeige EIF4EBP1 Antikörper) abundance and phosphorylation as well as different eIF4E/4E-BP1 (zeige EIF4EBP1 Antikörper) binding dynamic depending on the type of implantation.

  5. Modified translational initiation of eIF4E may particularly regulate protein synthesis during conceptus attachment at the time of implantation in swine.

  6. Translation initiation factor eIF4E is phosphorylated during in vitro maturation of pig oocytes with a maximum in metaphase II stage oocytes.

EIF4E Antigen-Profil

Protein Überblick

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit EIF4E

  • Eukaryotic initiation factor 4E (eIF-4E) Antikörper
  • eucaryotic initiation factor 6 (eif6) Antikörper
  • eukaryotic translation initiation factor 4E (eif4e) Antikörper
  • eukaryotic translation initiation factor 4E family member 1B S homeolog (eif4e1b.S) Antikörper
  • eukaryotic translation initiation factor 4E (EIF4E) Antikörper
  • eukaryotic translation initiation factor 4E (Eif4e) Antikörper
  • eukaryotic translation initiation factor 4E L homeolog (eif4e.L) Antikörper
  • eukaryotic translation initiation factor 4ea (eif4ea) Antikörper
  • translation initiation factor eIF4E (LOC100533326) Antikörper
  • 2 Antikörper
  • 0260/09 Antikörper
  • 0587/11 Antikörper
  • 0589/11 Antikörper
  • 0919/12 Antikörper
  • 1004/13 Antikörper
  • 7238 Antikörper
  • AUTS19 Antikörper
  • cbp Antikörper
  • CG4035 Antikörper
  • CT13384 Antikörper
  • CT39424 Antikörper
  • CT39426 Antikörper
  • D-eIF4E Antikörper
  • deIF-4E Antikörper
  • deIF4E Antikörper
  • Dmel\\CG4035 Antikörper
  • EG668879 Antikörper
  • EIF-4E Antikörper
  • eIF-4E1 Antikörper
  • eIF-4E2 Antikörper
  • eIF-4EII Antikörper
  • eif4e Antikörper
  • eIF 4E Antikörper
  • eif4e-1 Antikörper
  • eIF4E-1/2 Antikörper
  • eIF4E-2 Antikörper
  • Eif4e-ps Antikörper
  • EIF4E1 Antikörper
  • eIF4EI Antikörper
  • EIF4EL1 Antikörper
  • EIF4F Antikörper
  • If4e Antikörper
  • l(3)07238 Antikörper
  • l(3)67Af Antikörper
  • l(3)S025007 Antikörper
  • l(3)S026009 Antikörper
  • l(3)S058711 Antikörper
  • l(3)S091912 Antikörper
  • zgc:86680 Antikörper

Bezeichner auf Proteinebene für EIF4E

CG4035-PA , CG4035-PB , CG4035-PC , CG4035-PD , CG4035-PE , CG4035-PF , CG4035-PG , CG4035-PH , CG4035-PI , cap binding protein , eIF-4E-PA , eIF-4E-PB , eIF-4E-PC , eIF-4E-PD , eIF-4E-PE , eIF-4E-PF , eIF-4E-PG , eIF-4E-PH , eIF-4E-PI , eukaryotic initiation factor 4E , eukaryotic translation initiation factor 4E , lethal(3)67Af , eucaryotic initiation factor6 , eIF4E , PCO081734 , PCO081734_ov , mRNA cap-binding protein , eukaryotic translation initiation factor small subunit , eIF-4F 25 kDa subunit , eIF-4E , eukaryotic translation initiation factor 4E-like 1 , elongation initiation factor 4E , eukaryotic translation initiation factor 4e 1a , eukaryotic translation initiation factor eIF4E-1

GENE ID SPEZIES
45525 Drosophila melanogaster
542608 Zea mays
548663 Xenopus (Silurana) tropicalis
399255 Xenopus laevis
1977 Homo sapiens
13684 Mus musculus
117045 Rattus norvegicus
422703 Gallus gallus
734259 Xenopus laevis
281751 Bos taurus
100009338 Oryctolagus cuniculus
487870 Canis lupus familiaris
100038030 Sus scrofa
79380 Danio rerio
100533326 Aplysia californica
Ausgewählte Anbieter für anti-EIF4E (EIF4E) Antikörper
Haben Sie etwas anderes gesucht?