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The protein encoded by EIF4G1 is a component of the multi-subunit protein complex EIF4F. Zusätzlich bieten wir Ihnen Eukaryotic Translation Initiation Factor 4 Gamma, 1 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal EIF4G1 Primary Antibody für IP, WB - ABIN151736 : Escobar, Frank, Suryawan, Nguyen, Davis: Amino acid availability and age affect the leucine stimulation of protein synthesis and eIF4F formation in muscle. in American journal of physiology. Endocrinology and metabolism 2007 (PubMed) Show all 25 Pubmed References
Human Polyclonal EIF4G1 Primary Antibody für IHC (p), IHC - ABIN316278 : Dobrikov, Dobrikova, Shveygert, Gromeier: Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1. in Molecular and cellular biology 2011 (PubMed) Show all 3 Pubmed References
The structures of eIF4E (zeige EIF4E Antikörper)-eIF4G complexes reveal an extended interface to regulate translation initiation.
Phosphorylation of 4E-BP1 (zeige EIF4EBP1 Antikörper) impairs the competition with eIF4G for eIF4E (zeige EIF4E Antikörper) binding.
The eIF4G knockdown did not affect male fertility.
Data show that in the early embryo dFMRP (zeige FMR1 Antikörper) associates specifically with Caprin, and with eIF4G, a key regulator of translational initiation.
A novel eIF4G homolog, Off-schedule, couples translational control to meiosis and differentiation in Drosophila spermatocytes.
coordinated and selective recruitment of eIF4E (zeige EIF4E Antikörper) and eIF4G factors at a very early step in potyvirus infection
EIF4G1 overexpression is associated with non-small cell lung cancers.
High EIF4G expression is associated with malignant peripheral nerve sheath tumors and vestibular schwannomas.
The study indicates that the EIF4G1 mutation is rare in Taiwan, which is consistent with other reports from Asia. Ethnicity could have a great influence on EIF4G1 in Parkinson's disease.
the IRES of encephalomyocarditis virus (EMCV) interacts with the HEAT-1 domain of eukaryotic initiation factor 4G (eIF4G).
Data show that targeting translation initiation (TI) factors eIF4E (zeige EIF4E Antikörper)/eIF4GI reduces migration and epithelial-to-mesenchymal transition (EMT (zeige ITK Antikörper)), both essential for metastasis, thereby underscoring the potential of TI targeting in non-small cell lung cancer (NSCLC) therapy.
EIF4G1 mutations are not related to Parkinson's disease
VPS35 (zeige vps35 Antikörper) D620N and EIF4G1 R1205H mutations are not a common cause of Parkinson disease in the Greek population.
This study is the first to directly assess the relative contribution of eIF4F (zeige EIF4A2 Antikörper) components to the expressed cellular proteome, transcription factors, microRNAs, and phenotype in multiple myeloma
EIF4GI shares this activity and also interacts with eIF1 (zeige EIF1 Antikörper).
Our studies reveal unexpected genetic and functional interactions between VPS35 and EIF4G1, two seemingly unrelated PD genes, and functionally connect them to alpha-synuclein pathobiology in yeast, worms, and mouse.
Disruption of insulin receptor (IR (zeige INSR Antikörper)) expression in beta cells has a direct impact on the expression of the convertase enzyme carboxypeptidase E (CPE (zeige CPE Antikörper)) by inhibition of the eukaryotic translation initiation factor (zeige EIF2A Antikörper) Eif4g1.
Data indicate that MNK2 (zeige MKNK2 Antikörper) plays a unique role, not shared by its closest paralog MNK1 (zeige MKNK1 Antikörper), in limiting protein translation through its negative effect on eIF4G Ser1108 phosphorylation and p70S6K (zeige RPS6KB1 Antikörper) activation.
expression of 3e5 diminishes eIF4G interaction with eIF3 (zeige EIF3A Antikörper) and causes abnormal gene expression at the translational level.
findings assign NAD(P)H (zeige NQO1 Antikörper) quinone-oxydoreductase 1 an original role in the regulation of mRNA translation via the control of eIF4GI stability by the proteasome.
downregulated expression in T cells following treatment with bis (zeige BAG3 Antikörper)(tri (zeige VANGL2 Antikörper)-n-butylin)oxide (TBTO), an immunotoxic organotin compound
eIF4G binding to Mnk (zeige ATP7A Antikörper) is inhibted by Mnk1 (zeige MKNK1 Antikörper) phosphorylation by caspase (zeige CASP3 Antikörper)-activated Pak2/gamma-PAK (zeige PAK2 Antikörper)
Comparison of the p53 (zeige TP53 Antikörper)-induced patterns of eIF4GI and 4E-BP1 (zeige EIF4EBP1 Antikörper) dephosphorylation and cleavage with those caused by the mammalian target of rapamycin (zeige FRAP1 Antikörper) inhibitor rapamycin
These findings suggest that the ability of cells to rephosphorylate 4E-BP1 (zeige EIF4EBP1 Antikörper), resynthesise eIF4GI and restore the rate of protein synthesis after inactivation of p53 (zeige TP53 Antikörper) is an important aspect of recovery following the relief of physiological stress.
interactions between Pdcd4 (zeige PDCD4 Antikörper) and components of the translation initiation complex, namely, the RNA helicase eIF4A (zeige EIF4A1 Antikörper) and the scaffolding protein eIF4G
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.
eukaryotic translation initiation factor 4 gamma 1 , CG10811-PA , CG10811-PB , CG10811-PC , Eukaryotic-initiation-factor-4G , eIF-4G , eIF4G-PA , eIF4G-PB , eIF4G-PC , eukaryotic initiation factor 4G , translation initiation factor , translation initiation factor eIF4G , eukaryotic translation initiation factor 4 gamma, 1 , fb50a05 , eukaryotic initiation factor , eukaryotic translation initiation factor 4 gamma , eukaryotic translation initiation factor 4 gamma 1-like , EIF4-gamma , eIF-4-gamma 1 , eucaryotic translation initiation factor 4G , eIF-4G 1 , eIF-4G1