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Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. Zusätzlich bieten wir Ihnen EIF2S2 Antikörper (71) und viele weitere Produktgruppen zu diesem Protein an.
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Mass spectrometry of CXCR4 (zeige CXCR4 Proteine) immunoprecipitates revealed a specific interaction with the pentameric eukaryotic translation initiation factor (zeige EIF2A Proteine) 2B.
This study provides mechanistic insight into the role of eIF5-carboxyl terminal domain's dynamic interplay with eIF1 and eIF2beta
These findings suggest that alpha and beta subunits of eIF2 (zeige EIF2S1 Proteine) interact with each other and the beta-subunit (zeige POLG Proteine) plays a critical role both in the regulation and function of eIF2 (zeige EIF2S1 Proteine).
This study provides evidence that even a mild mutation in eIF2B (zeige EIF2B4 Proteine), leading merely to a ~ 20% decrease in its enzymatic activity, is associated with mitochondrial malfunction caused by defective oxphos and with increased mitochondrial biogenesis compensating for energetic needs.
GCN2 (zeige EIF2AK4 Proteine) activation increased phosphorylation of its substrate eIF2alpha (zeige EIF2A Proteine) and the induction of the integrated stress response master regulator, ATF4 (zeige ATF4 Proteine).
BMP-2 (zeige BMP2 Proteine) stimulates differentiation of myoblasts into osteoblasts via the PERK (zeige EIF2AK3 Proteine)-eIF2alpha (zeige EIF2A Proteine)-ATF4 (zeige ATF4 Proteine) pathway but in addition stimulates Tmem119, which itself increases ATF4 (zeige ATF4 Proteine)
This study extends our understanding of the roles played by GCN1 in GCN2 (zeige EIF2AK4 Proteine) activation induced by a variety of stress arrangements and suggests that IMPACT and YIH1 use similar mechanisms for regulating this eIF2alpha (zeige EIF2A Proteine) kinase.
Study found that the incidence of testicular germ cell tumor in affected males was reduced 2-fold in mice that were partially deficient for Eif2s2 and embryonic lethality occurred near the time of implantation in mice that were fully deficient for Eif2s2.
Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation.
eukaryotic translation initiation factor 2 subunit 2
, eukaryotic translation initiation factor 2 subunit beta
, protein phosphatase 1, regulatory subunit 67
, eukaryotic translation initiation factor 2, subunit 2 (beta, 38kDa)
, eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
, eukaryote initiation factor 2 beta
, eukaryotic translation initiation factor 2 beta
, eukaryotic initiation factor 2 beta (eIF-2 beta)
, eukaryotic translation initiation factor 2 subunit 2 pseudogene