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EIF1AX encodes an essential eukaryotic translation initiation factor. Zusätzlich bieten wir Ihnen EIF1AX Antikörper (26) und und viele weitere Produktgruppen zu diesem Protein an.
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Study identified a new RNA-induced silencing complex component, eIF1A, which directly interacts with the MID-domain of Ago2 (zeige EIF2C2 Proteine) and functions in DICER (zeige DICER1 Proteine)-independent miRNA biogenesis and miRNA-mediated RNA interference.
EIF1AX alterations occurred infrequently in low-grade gliomas (1.4%), uterus endometrial carcinoma (1.25%), thyroid carcinoma (1%), and lung adenocarcinoma (0.4%).
Coexpression of mutant NRAS (zeige NRAS Proteine) and EIF1AX proteins promoted proliferation and clonogenic survival in LGSC cells, providing the first example of co-occurring, growth-promoting mutational events in ovarian cancer.
Short 5'UTR mRNAs are enriched with TISU (translation initiator of short 5'UTR), a 12-nucleotide element directing efficient scanning-independent translation. This study demonstrate that TISU is particularly dependent on eukaryotic initiation factor (zeige EIF4G1 Proteine) 1A (eIF1A) which interacts with both RPS3 (zeige RPS3 Proteine) and RPS10e.
Mutation in EIF1AX gene is associated with Uveal Melanoma.
we find iris melanomas to be related genetically to choroidal and ciliary body melanomas, frequently harboring GNAQ (zeige GNAQ Proteine), GNA11 (zeige GNA11 Proteine), and EIF1AX mutations.
results indicate that the interactions between eIF1A and eIF5B (zeige EIF5B Proteine) are being continuously rearranged during translation initiation; presentation of a model how the dynamic eIF1A/eIF5B (zeige EIF5B Proteine) interaction network can promote remodeling of the translation initiation complexes, and the roles in the process played by intrinsically disordered protein segments
Patients with uveal melanoma can be classified into 3 groups, of which EIF1AX-mutated tumors and tumors without BAP1 (zeige RNF2 Proteine), SF3B1 (zeige SF3B2 Proteine), or EIF1AX mutations are associated with prolonged survival and low metastatic risk, SF3B1 (zeige SF3B2 Proteine)-mutated tumors are associated with late metastasis
BAP1 (zeige RNF2 Proteine), SF3B1 (zeige SF3B2 Proteine), and EIF1AX mutations occur during uveal melanoma tumor progression in an almost mutually exclusive manner and are associated with different levels of metastatic risk.
We report here the occurrence of EIF1AX mutations not only in thyroid cancer, but also in benign thyroid nodules, and demonstrate that phenotypically these mutations are associated with the encapsulated follicular variant of papillary thyroid carcinoma and benign follicular-pattern nodules.
This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA.
Putative eukaryotic translation initiation factor 1A
, eIF-1A X isoform
, eukaryotic translation initiation factor 1A, X chromosome
, eukaryotic translation initiation factor 1A, X-chromosomal
, eukaryotic translation initiation factor 4C
, eukaryotic translation initiation factor 1A, Y-linked