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The protein encoded by EGR2 is a transcription factor with three tandem C2H2-type zinc fingers. Zusätzlich bieten wir Ihnen EGR2 Antikörper (124) und EGR2 Kits (25) und viele weitere Produktgruppen zu diesem Protein an.
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Low EGR2 expression is associated with hepatocellular carcinoma.
The study suggests that acetylation of EGR2 is regulated independently of nucleosome remodeling and deacetylase.
Egr2-driven cell surface proteins LAG-3 (zeige LAG3 Proteine) and 4-1BB (zeige TNFRSF9 Proteine) can identify dysfunctional tumor antigen-specific CD8 (zeige CD8A Proteine)(+) TIL (zeige TLR1 Proteine).
Egr2 and Egr3 (zeige EGR3 Proteine) have emerged as regulatory molecules that suppress excessive immune responses. Mice deficient for Egr2 and Egr3 (zeige EGR3 Proteine) develop a lupus-like disease with dysregulated activation of effector T cells. Egr2 and Egr3 (zeige EGR3 Proteine) confer suppressive activity to CD4 (zeige CD4 Proteine)(+) T cells and regulate the production of inhibitory cytokines such as IL-10 (zeige IL10 Proteine) and TGF-beta1 (zeige TGFB1 Proteine).
Analysis of consensus EGR (zeige EGR1 Proteine)-binding elements (EBEs) showed that the immediate early response 3 (zeige IER3 Proteine) gene (IER3 (zeige IER3 Proteine)) is a novel transcriptional target gene of EGR2 as confirmed by the luciferase assay, electrophoretic mobility-shift assay (EMSA), chromatin immunoprecipitation (ChIP), and western blot analysis.
In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2 (zeige NR4A2 Proteine))early growth response (EGR)2 and NR4A2EGR3. Therefore, RUNX1 (zeige RUNX1 Proteine), NR4A2 (zeige NR4A2 Proteine), EGR2, EGR3 (zeige EGR3 Proteine) and ID4 (zeige ID4 Proteine) may be key genes associated with the pathogenesis of DS.
EGR2 mutation presents as an axonal Charcot-Marie-Tooth phenotype with variable severity.
MicroRNA20a promotes the proliferation and cell cycle of human osteosarcoma cells by suppressing EGR2 expression.
These results suggested that EGR2 overexpression has a pivotal role in the downregulation of cytokines implicated in the pathophysiology of Guillain-Barre syndrome
A recurrent mutation was identified in EGR2 which appears to be associated with the pathogenesis of schizophrenia.
Prss56 expression was regulated by Egr2 during mouse decidualization.
Egr2 and 3 are upstream regulators of effector CD4 (zeige CD4 Proteine) and CD8 (zeige CD8A Proteine) T cells that are essential for optimal responses with limited immunopathology.
Egr2 and 3 are antagonists of T-bet function in effector T cells and are important for the control of inflammatory responses of T cells.
We discovered that Tead1 (zeige TEAD1 Proteine) and co-activators Yap (zeige YAP1 Proteine) and Taz (zeige TAZ Proteine) are required for Pmp22 (zeige PMP22 Proteine) expression, as well as for the expression of Egr2 Tead1 (zeige TEAD1 Proteine) directly binds Pmp22 (zeige PMP22 Proteine) and Egr2 enhancers early in development and Tead1 (zeige TEAD1 Proteine) binding is induced during myelination, correlating with Pmp22 (zeige PMP22 Proteine) expression. The data identify Tead1 (zeige TEAD1 Proteine) as a novel regulator of Pmp22 (zeige PMP22 Proteine) expression during development in concert with Sox10 (zeige SOX10 Proteine) and Egr2
endogenous KLF4 (zeige KLF4 Proteine) and Krox20 are dispensable for adipogenesis in culture and for brown adipose tissue development in mice. In contrast, the master adipogenic transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma (zeige PPARG Proteine)) is essential.
Decreased expression of Krox20 in mice causes degeneration of the aortic leaflets and disorganization of the extracellular matrix, causing valvular dysfunction.
Mir106b regulates pro-allergic properties of dendritic cells and Th2 polarisation by targeting Egr-2 in vitro
let-7 miRNAs promote expression of the myelination-driving master transcription factor Krox20
The data suggest that Pak2 (zeige PAK2 Proteine) controls thymic Natural Killer T-cell development by providing a signal that links Egr2 to induce PLZF (zeige ZBTB16 Proteine), in part by regulating signaling lymphocyte activation molecule (zeige SLAMF1 Proteine) 6 expression.
demonstrate a novel function of EGR2/3 that is important for Tfh cell development and Tfh cell-mediated B cell immune responses
A direct, positive autoregulatory loop amplifies and maintains the expression of Krox20, a transcription factor governing vertebrate hindbrain segmentation.
Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.
Data show that Irx7 and Irx1b are required for the proper formation and specification of rhombomeres 1 to 4, and that Irx7 functionally interacts with Meis1.1 (zeige MEIS1 Proteine) to activate the expression of anterior hindbrain markers, such as krox20.
The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene.
E3 SUMO-protein ligase EGR2
, KROX-20, Drosophila, homolog (early growth response-2)
, early growth response protein 2
, zinc finger protein Krox-20
, early growth response 2 (Krox-20 homolog, Drosophila)
, early growth response protein 2b
, protein krx-20