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Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family (By similarity). Zusätzlich bieten wir Ihnen ELMO/CED-12 Domain Containing 1 Antikörper (35) und viele weitere Produktgruppen zu diesem Protein an.
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Data suggest that GPR124 promotes cell adhesion via interaction with Elmo1 (zeige ELMO1 Proteine)-Dock180 (zeige DOCK1 Proteine) and intersectin 1/2; this constitutes a previously unrecognized heteromeric complex that is putatively involved in GPR124-dependent adhesive/angiogenic responses in vascular endothelial cells. (GPR124 = G-protein coupled receptor 124; Elmo1 (zeige ELMO1 Proteine) = ELMO domain-containing protein 1; Dock180 (zeige DOCK1 Proteine) = dedicator of cytokinesis protein 1 (zeige DOCK1 Proteine) 180 kDa)
The non-opioid sigma-1 receptor (S1R) was identified as a novel effector of GAP activity of ELMOD1-3 proteins as its direct binding to either ELMOD1 or ELMOD2 (zeige ELMOD2 Proteine) resulted in loss of GAP activity.
Elmod1 has relatively high and selective expression in the brain but as of 2014 has not been well-studied with respect to CNS function or disease associations. It is part of the core brain ignorome. Elmod1 has a high cis (zeige CISH Proteine)-eQTL (zeige EQTN Proteine) in hippocampus, hypothalamus, striatum. Hearing sensitivity trait in GeneNetwork.org also maps to the region containing Elmod1.
This finding connecting ELMOD1 deficiencies with stereocilia dysmorphologies establishes a link between the Ras superfamily of small regulatory GTPases and the actin cytoskeleton dynamics of hair cell stereocilia.
Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family (By similarity).
ELMO domain containing 1
, ELMO domain-containing protein 1