EF-Hand Calcium Binding Domain 4B Proteine (EFCAB4B)

Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Zusätzlich bieten wir Ihnen EF-Hand Calcium Binding Domain 4B Antikörper (54) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
EFCAB4B 84766 Q9BSW2
EFCAB4B 381812 Q3UP38
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Top EF-Hand Calcium Binding Domain 4B Proteine auf antikoerper-online.de

Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
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EFCAB4B Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu EF-Hand Calcium Binding Domain 4B (EFCAB4B) Interaktionspartnern

Human EF-Hand Calcium Binding Domain 4B (EFCAB4B) Interaktionspartner

  1. Results show the characterization of CRACR2A protein which encodes a large Rab GTPase (zeige RAB6A Proteine) containing multiple functional domains contrary to small Rab (zeige HRB Proteine) GTPases. It was found to play an unexpected role in regulating intracellular signaling pathways important for T cell activation.

  2. GTP binding (zeige RND2 Proteine) and prenylation of CRACR2A were associated with its localization near the Golgi and its stability

  3. endothelial cells contain a long variant of CRACR2A which is an EF-hand-containing Rab (zeige HRB Proteine) protein that lacks impact on CRAC channels

  4. CRACR2A interacts directly with Orai1 and STIM1 (zeige STIM1 Proteine), forming a ternary complex that dissociates at elevated Ca(2 (zeige CA2 Proteine)+) concentrations; is a key regulator of CRAC channel-mediated SOCE

Mouse (Murine) EF-Hand Calcium Binding Domain 4B (EFCAB4B) Interaktionspartner

  1. GTP binding (zeige RND2 Proteine) and prenylation of CRACR2A (zeige EFCAB4A Proteine) were associated with its localization near the Golgi and its stability

EF-Hand Calcium Binding Domain 4B (EFCAB4B) Protein Überblick

Protein Überblick

Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex (By similarity).

Genbezeichner und Symbole assoziert mit EFCAB4B

  • calcium release activated channel regulator 2A (CRACR2A)
  • calcium release activated channel regulator 2A (Cracr2a)
  • CRACR2A Protein
  • Gm462 Protein
  • Gm1073 Protein

Bezeichner auf Proteinebene für EFCAB4B

CRAC channel regulator 2A , EF-hand calcium-binding domain-containing protein 4B , calcium release-activated calcium channel regulator 2A

GENE ID SPEZIES
84766 Homo sapiens
381812 Mus musculus
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