Dystrobrevin alpha Proteine (DTNA)

The protein encoded by DTNA belongs to the dystrobrevin subfamily of the dystrophin family. Zusätzlich bieten wir Ihnen DTNA Antikörper (81) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
DTNA 13527 Q9D2N4
DTNA 1837 Q9Y4J8
Ratte DTNA DTNA 307548  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$11,073.30
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$11,073.30
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$333.33
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DTNA Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
, ,

Weitere Proteine zu Dystrobrevin alpha (DTNA) Interaktionspartnern

Zebrafish Dystrobrevin alpha (DTNA) Interaktionspartner

  1. Ordered disorder of the astrocytic dystrophin (zeige DMD Proteine)-associated protein complex in the norm and pathology.

Mouse (Murine) Dystrobrevin alpha (DTNA) Interaktionspartner

  1. A phosphorylation site on alpha-dystrobrevin-1 is essential for functional interactions with several proteins at the neuromuscular junction.

  2. Alpha-dystrobrevin is a multifunctional protein that increases dystrophin's binding to the dystrophin (zeige DMD Proteine)-glycoprotein complex.

  3. Loss of alpha dystrobrevin is associated with perturbation in cell cycle progression and nuclei shape.

  4. Ordered disorder of the astrocytic dystrophin (zeige DMD Proteine)-associated protein complex in the norm and pathology.

  5. alpha-dystrobrevin emerges as a central organizer of dystrophin-associated protein in glial endfeet and a rare example of a glial protein with a role in maintaining BBB function

  6. the interaction between alpha-catulin (zeige CTNNAL1 Proteine) and alpha-dystrobrevin is evolutionarily conserved in C. elegans and mouse muscles and strongly suggests that this interaction contributes to the integrity of the dystrophin (zeige DMD Proteine) complex

  7. The ErbB2 (zeige ERBB2 Proteine) signaling maintains high efficacy of synaptic transmission by stabilizing the postsynaptic apparatus via phosphorylation of alpha-dystrobrevin1.

  8. This is the first demonstration in which assembly of an astroglial protein scaffold containing syntrophin and dystrophin (zeige DMD Proteine) in perivascular astrocytes is dependent on the presence of alpha-dystrobrevin.

  9. Fundamental functional differences between the alpha-dystrobrevins of mice and humans raises questions about the use of the mouse as a model animal for Duchenne muscular dystrophy (zeige DMD Proteine).

  10. identified a new dystrobrevin-associated protein, DAMAGE; interacts with the N-terminal region of alpha-dystrobrevin

Human Dystrobrevin alpha (DTNA) Interaktionspartner

  1. our findings suggest that novel mutations in FAM136A and DTNA genes are probably causal variants in FMD (zeige FLNA Proteine).

  2. Ordered disorder of the astrocytic dystrophin (zeige DMD Proteine)-associated protein complex in the norm and pathology.

  3. Results suggest that alpha-dystrobrevin isoforms play a central role in cytoskeleton reorganization via their multiple interactions with actin and actin-associating proteins.

  4. Data show that alpha-dystrobrevin-1 recruits alpha-catulin (zeige CTNNAL1 Proteine), which supersensitizes alpha(1D)-AR functional responses by recruiting effector molecules to the signalosome.

  5. Fundamental functional differences between the alpha-dystrobrevins of mice and humans raises questions about the use of the mouse as a model animal for Duchenne muscular dystrophy (zeige DMD Proteine).

  6. During a cycle of regeneration in tibialis anterior muscle following myonecrosis, alpha-dystrobrevin reaches 50% of the protein level on day 28 by 6.6 days, regenerating more slowly than dystrophin (zeige DMD Proteine).

  7. alpha-dystrobrevin and its splice isoforms have a role in signal transduction in myeloid cells during induction of granulocytic differentiation and/or at the commitment stage of differentiation or phagocytic cells

  8. Transgenic expression of either isoform of alpha-dystrobrevin prevented muscle fiber degeneration in knockout mice; however, only alphaDB1 corrected defects at neuromuscular and musculotendinous junctions.

  9. patients with deficiency of beta2-syntrophin and alpha-dystrobrevin presented with severe congenital weakness and died in the first year, and patients with deficiency of alpha-DNT (zeige NT5C Proteine) had congenital muscular dystrophy with complete external ophthalmoplegia.

  10. findings suggest that a-dystrobrevin specifically is associated with the tight junctions during their reorganization

DTNA Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Genbezeichner und Symbole assoziert mit Dystrobrevin alpha Proteine (DTNA)

  • dystrobrevin alpha (DTNA)
  • dystrobrevin, alpha (dtna)
  • dystrobrevin alpha (LOC100195747)
  • dystrobrevin alpha (dtna)
  • dystrobrevin alpha (Dtna)
  • dystrobrevin, alpha (Dtna)
  • 2210407P21Rik Protein
  • a-DB-1 Protein
  • A0 Protein
  • adbn Protein
  • adtn Protein
  • atnb Protein
  • D18S892E Protein
  • DRP3 Protein
  • DTN Protein
  • DTN-A Protein
  • Dtna-ps1 Protein
  • LVNC1 Protein
  • MGC146484 Protein
  • RGD1561985 Protein

Bezeichner auf Proteinebene für Dystrobrevin alpha Proteine (DTNA)

alpha-dystrobrevin isoform 1a- , alpha-dystrobrevin isoform 1b+ , alpha-dystrobrevin isoform 1c- , alpha-dystrobrevin isoform 4a- , dystrobrevin, alpha , dystrobrevin alpha , Dystrobrevin alpha , DTN-A , alpha-dystrobrevin , dystrophin-related protein 3 , dystrobrevin alpha, pseudogene 1

GENE ID SPEZIES
421104 Gallus gallus
455367 Pan troglodytes
794932 Danio rerio
100195747 Salmo salar
100351412 Oryctolagus cuniculus
779813 Xenopus (Silurana) tropicalis
13527 Mus musculus
100627907 Sus scrofa
1837 Homo sapiens
490488 Canis lupus familiaris
541153 Bos taurus
307548 Rattus norvegicus
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