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Cytoplasmic dynein is a microtubule-associated motor protein (Hughes et al., 1995 [PubMed 7738094]). Zusätzlich bieten wir Ihnen Dynein, Cytoplasmic 1, Light Intermediate Chain 2 Antikörper (34) und und viele weitere Produktgruppen zu diesem Protein an.
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Cortically localized dynein, essential for maintaining correct spindle orientation, consists majorly of LIC2-dynein, which interacts with cortical 14-3-3 epsilon- zeta and Par3, conserved proteins required for orienting the spindle.
This study uncovers a novel functional hierarchy during mitotic checkpoint inactivation between the closely related but homologous LIC subunits of cytoplasmic dynein.
These results suggest that cytoplasmic dynein 1 binds to BRCA2 through the latter's centrosomal localization signal and BRCA2 mediates the cohesion between centrosomes during the S phase, potentially serving as a cell-cycle checkpoint.
although dynein lacking light intermediate chains (LICs) drives microtubule gliding at normal rates, the LICs are required for the formation and maintenance of a bipolar spindle.
using a variety of complementary approaches, our results indicate a novel specific role for the LICs in dynein recruitment to components of the late endocytic pathway.
FIP3 was identified as the first membrane-associated interacting-partner for DLIC-2.
Cytoplasmic dynein is a microtubule-associated motor protein (Hughes et al., 1995
cytoplasmic dynein 1 light intermediate chain 2
, dynein, cytoplasmic 1, light intermediate chain 2
, LIC-2 dynein light intermediate chain 53/55
, dynein light intermediate chain 2, cytosolic
, dynein, cytoplasmic, light intermediate polypeptide 2
, dynein, cytoplasmic, light intermediate chain 2