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The protein encoded by DUOX1 is a glycoprotein and a member of the NADPH oxidase family. Zusätzlich bieten wir Ihnen DUOX1 Proteine (7) und DUOX1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal DUOX1 Primary Antibody für IHC (p), IHC - ABIN449366
Kippner, Finn, Shukla, Kemp: Systemic remodeling of the redox regulatory network due to RNAi perturbations of glutaredoxin 1, thioredoxin 1, and glucose-6-phosphate dehydrogenase. in BMC systems biology 2011
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dual oxidase Udx1 has a role in the oxidative burst at fertilization
The duox expression in zebrafish during early nervous system development from 12 to 48 hours post fertilization.
The results reveal a crucial role for TNFalpha (zeige TNF Antikörper)/TNFR2 (zeige TNFRSF1B Antikörper) axis in the protection of the skin against DUOX1-mediated oxidative stress.
extracellular ATP acting as an early danger signal is responsible for the activation of Duox1 via a P2YR/PLC (zeige PLC Antikörper)/Ca(2 (zeige CA2 Antikörper)+) signaling pathway and the production of H2O2
Zebrafish duox is highly expressed in intestinal epithelial cells. Knockdown of Duox impaired larval capacity to control enteric Salmonella infection.
We analyzed the expression of NADPH oxidase (zeige NOX1 Antikörper) isoforms and found both A431 and HaCaT cells to express the calcium-sensitive NADPH oxidase (zeige NOX1 Antikörper), Dual oxidase 1 (Duox1) and its protein partner Duox activator 1 (DuoxA1 (zeige DUOXA1 Antikörper)).Our observations provide evidence for a new signaling paradigm in which changes of intracellular calcium concentration are transformed into redox signals through the calcium-dependent activation of Duox1.
DUOX1 missense mutation plays a role in congenital hypothyroidism.
Our findings implicate epithelial DUOX1 as a pivotal mediator of IL-33 (zeige IL33 Antikörper)-dependent activation of innate airway type 2 immune responses to common airborne allergens and indicate that enhanced DUOX1 expression and IL-33 (zeige IL33 Antikörper) secretion might present important contributing features of allergic asthma.
Cox (zeige COX8A Antikörper) multivariate regression analysis demonstrated that DUOX1, GLS2 (zeige GLS2 Antikörper), FBP1 (zeige FBP1 Antikörper) and age were independent risk factors for the prognosis of HCC (zeige FAM126A Antikörper) patients after surgery
DUOX1 expression in liver tumors is a potential prognostic tool for patients.
Nox4 (zeige NOX4 Antikörper) and Duox1/Duox2 mediate redox activation of mesenchymal cell migration by PDGF (zeige PDGFA Antikörper).
These data reveal a key role of DUOX1-dependent hydrogen peroxide production in long-term persistent radio-induced DNA damage.
Studies demonstrate the importance of DUOX1 in epithelial redox signaling through reversible S-glutathionylation of a range of proteins, including proteins involved in cytoskeletal regulation and MAPK (zeige MAPK1 Antikörper) signaling pathways involved in cell migration.
Duox2 (zeige DUOX2 Antikörper) proteins possessing the A-loops of Nox1 (zeige NOX1 Antikörper) or Nox5 (zeige NOX5 Antikörper) co-expressed with DuoxA2 (zeige DUOXA2 Antikörper) showed enhanced O2 () release, and Duox1 proteins possessing the A-loops of Nox1 (zeige NOX1 Antikörper) or Nox5 (zeige NOX5 Antikörper) co-expressed with DuoxA1 (zeige DUOXA1 Antikörper) acquired O2 () leakage
DUOX1 is the major H2O2-producing source in NHKs stimulated with Ca(2 (zeige CA2 Antikörper)+), and plays a significant role in regulating the expression of specific markers necessary for the normal differentiation of keratinocytes
Data, including data from studies using transgenic mice, suggest that over-expression of IL4 (interleukin 4) in thyroid tissue/cells up-regulates expression of Duox1 (dual oxidase 1), Duoxa1 (dual oxidase maturation factor 1), and Slc26a4 (pendrin) in thyroid tissue/cells; expression of Slc5a5 (sodium-iodide symporter) is down-regulated.
Redox-dependent regulation of EGFR (zeige EGFR Antikörper) activation in airway epithelial cells was found to strongly depend on activation of either DUOX1 or NOX2 (zeige CYBB Antikörper).
findings suggest that LPS (zeige TLR4 Antikörper)-TLR-4 (zeige TLR4 Antikörper)-induced KC or MIP-2 (zeige CXCL2 Antikörper) cytokine induction and subsequent neutrophil recruitment in the airway does not require DUOX-derived hydrogen peroxide from airway epithelium
These findings suggest that DUOX-derived H2O2 has an important role in signaling neutrophils into allergic airways
PA-LPS (zeige TLR4 Antikörper)-induced MUC5AC and Clca3 (zeige CLCA3P Antikörper) expression is partly through Duox1
In vivo DUOX1 silencing significantly suppressed naphthalene-induced activation of STAT3 (zeige STAT3 Antikörper).
Urothelial cells produce hydrogen peroxide through the activation of Dual oxidase 1
Duox1 is the main source of H(2)O(2) in the rat thyroid cell line PCCl3.
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
dual oxidase 1
, NADPH thyroid oxidase 1
, flavoprotein NADPH oxidase
, large NOX 1
, long NOX 1
, nicotinamide adenine dinucleotide phosphate oxidase
, thyroid oxidase 1
, dual oxidase 2