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Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes.
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Human Polyclonal DLX4 Primary Antibody für IHC (p), IP - ABIN151928
Stevenson, Fu, Pinzone, Rheey, Simmens, Berg: BP1 transcriptionally activates bcl-2 and inhibits TNFalpha-induced cell death in MCF7 breast cancer cells. in Breast cancer research : BCR 2008
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Human Monoclonal DLX4 Primary Antibody für IP, RNAi - ABIN560620
Hara, Samuel, Liu, Rosen, Langley, Naora: A homeobox gene related to Drosophila distal-less promotes ovarian tumorigenicity by inducing expression of vascular endothelial growth factor and fibroblast growth factor-2. in The American journal of pathology 2007
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Polyclonal DLX4 Primary Antibody für IHC (fro), WB - ABIN540743
Chase, Fu, Haga, Davenport, Stevenson, Do, Morgan, Mah, Berg: BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene. in Molecular and cellular biology 2002
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Mouse (Murine) Polyclonal DLX4 Primary Antibody für WB - ABIN610693
Drees, Friederich, Fradelizi, Louvard, Beckerle, Golsteyn: Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. in The Journal of biological chemistry 2000
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Beta protein 1 (BP1) binds to and regulates estrogen receptor (zeige ESR1 Antikörper).
study indicated that DLX4 hypermethylation was a frequent event and acted as an independent prognostic biomarker in de novo myelodysplastic syndrome patients
Our study reveals that BP1 overexpression serves as an independent risk factor in de novo AML (zeige RUNX1 Antikörper) patients.
Collectively, our findings indicate that DLX4 exerts opposing effects on the megakaryocytic and erythroid lineages in part by inducing IL-1beta (zeige IL1B Antikörper) and NF-kappaB (zeige NFKB1 Antikörper) signaling.
DLX4 induces CD44 (zeige CD44 Antikörper) by stimulating IL-1beta (zeige IL1B Antikörper)-mediated NF-kappaB (zeige NFKB1 Antikörper) activity, thereby promoting peritoneal metastasis of ovarian cancer
This first finding of a DLX4 mutation in a family with Cleft lip and/or palate establishes DLX4 as a potential cause of human clefts
DLX4 promotes ovarian tumor angiogenesis in part by stimulating iNOS (zeige NOS2 Antikörper) expression.
Aberrant DNA methylation (zeige HELLS Antikörper) of the DLX4 and SIM1 (zeige SIM1 Antikörper) genes may be a novel progression marker for uterine cervical low-grade squamous intraepithelial lesions.
indicate that gains of DLX4 and ERBB2 (zeige ERBB2 Antikörper) occur in South African breast cancer patients irrespectively of their race and factors known to influence prognosis
a DLX4 overexpression vector lacking the 3'UTR (zeige UTS2R Antikörper) was shown to abolish miR (zeige MLXIP Antikörper)-122-induced inhibition of proliferation in the HCC (zeige FAM126A Antikörper) cell line Hep3B.
Genomic structure and functional control of the Dlx3 (zeige DLX3 Antikörper)-7 bigene cluster
nuclear import of Dlx4 is compromised by specific residues that flank the nuclear localization signal
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function.
distal-less homeobox 4
, beta protein 1
, distal-less homeo box 7
, distal-less homeo box 9
, homeobox protein DLX-4
, homeobox protein DLX-7
, homeobox protein DLX-8
, DII D