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DVL3 is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh.
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Dvl3 is overexpressed in human HCCs (zeige HCCS Antikörper). The NP-Dvl3 is the more stable and active form of the protein and enhances HCC (zeige FAM126A Antikörper) stemness.
we found that Wnt3a (zeige WNT3A Antikörper) treatment rapidly induces hyperphosphorylation and stabilization of Dvl2 (zeige DVL2 Antikörper) and Dvl3. Our findings suggest a model of positive regulation of PKCzeta (zeige PRKCZ Antikörper)-mediated Dvl (zeige DVL2 Antikörper) signaling activity, to produce a strong and sustained response to Wnt3a (zeige WNT3A Antikörper) treatment by stabilizing Dvl (zeige DVL2 Antikörper) protein levels.
Studied and identified candidate biomarkers of biochemical recurrence (BCR (zeige BCR Antikörper)) of prostate adenocarcinoma by integrating reverse-phase protein array (RPPA) and mRNA datafrom The Cancer Genome Atlas (TCGA). Found DVL3 was expressed in patients with a higher risk of BCR (zeige BCR Antikörper). DVL3 may be a novel and easily applicable recurrence predictor of localised prostate adenocarcinoma.
two mutually exclusive functions of the DEP (zeige ZDHHC21 Antikörper) domain in Wnt (zeige WNT2 Antikörper) signal transduction - binding to Frizzled to recruit Dishevelled (zeige DVL2 Antikörper) to the receptor complex, is reported.
Genetic changes between MLH1 (zeige MLH1 Antikörper) and MSH2 (zeige MSH2 Antikörper) were significantly positively correlated (p = 0.032). We also noted a positive correlation between genetic changes of MSH2 (zeige MSH2 Antikörper) and DVL3 genes (p = 0.034).
Data show that dishevelled (zeige DVL2 Antikörper) proteins DVL1 (zeige DVL1 Antikörper), 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).
Kif26b (zeige KIF26B Antikörper), together with Dvl3/Daam1 (zeige DAAM1 Antikörper), initiates cell polarity through the control of planar cell polarity-signaling pathway-dependent activation in endothelial cells.
DVL3 transcripts decreased in individuals with major depressive disorder
we demonstrate that normally ALFY (zeige WDFY3 Antikörper) attenuates the canonical Wnt (zeige WNT2 Antikörper) signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 (zeige DVL1 Antikörper) or Dvl2 (zeige DVL2 Antikörper).
All variants in DVL3 result in a -1 frameshift, indicating that these highly specific alterations might be a common cause of dominant Robinow syndrome.
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.
DSH homolog 3
, dishevelled 3 (homologous to Drosophila dsh)
, dishevelled, dsh homolog 3
, segment polarity protein dishevelled homolog DVL-3