Discs, Large Homolog 3 (Drosophila) (DLG3) ELISA Kits

DLG3 encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Zusätzlich bieten wir Ihnen DLG3 Antikörper (101) und DLG3 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
DLG3 1741 Q92796
Anti-Maus DLG3 DLG3 53310 P70175
Anti-Ratte DLG3 DLG3 58948 Q62936
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 0.115 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
$736.84
Details

Weitere ELISA Kits für DLG3 Interaktionspartner

Human Discs, Large Homolog 3 (Drosophila) (DLG3) Interaktionspartner

  1. These data provide evidence for a novel mechanism in regulating SAP102 function and glutamate receptor trafficking.

  2. This family broadens the mutational and phenotypical spectrum of DLG3-associated non-syndromic X-linked intellectual disability and demonstrates that heterozygous female mutation carriers can be as severely affected as males.

  3. Following the critical period NMDA receptor function was unaffected by loss of SAP102 but there was a reduction in the divergence of TC connectivity. These data suggest that changes in synaptic function early in development caused by mutations in SAP102 result in changes in network connectivity later in life.

  4. Insertion of a guanine into the DLG3 5' UTR, 7 bp upstream of the start codon, down regulated DLG3 protein levels. This non-coding variant segregates with X-linked intellectual disability in a large family.

  5. Trans-homophilic interaction of CADM1 activates PI3K by forming a complex with MAGuK-family proteins MPP3 and Dlg.

  6. miR-1246 might play a role in neurological pathogenesis of human enterovirus 71 by regulating DLG3 gene in infected cells.

  7. These data shed new light on the role of SAP102 in the regulation of NMDAR trafficking.

  8. This study identified DLG3 significantly associated loci with a biologically plausible role in schizophrenia.

  9. The data of this study suggested that DLG3 is down-regulated in this cancer type.

  10. The PDZ-independent interaction between SAP102 and GluN2B mediates the synaptic clearance of GluN2B-containing NMDARs.(SAP102 protein)

  11. Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin.

  12. A total of six novel and 11 known single nucleotide polymorphisms were identified. Further studies are warranted to analyze the candidate genes at Xq11.1-q21.33.

  13. DLG3 was identified by genome-wide gene expression analyses as correlated with cellular sensitivity to cisplatin and carboplatin. DLG3 was also found to correlate with cellular sensitivity to platinating agents in NCI-60 cancer cell lines.

  14. DLG3 did not associate with non-syndromic mental retardation in Chinese Han population; however, further studies are needed.

  15. Results identified a novel splice site mutation in the disc-large homolog 3 (DLG3) gene, encoding the synapse-associated protein 102 (SAP102) in one out of 300 families with moderate to severe non-syndromic mental retardation.

  16. Loss may lead to altered synaptic plasticity and may explain the intellectual impairment observed in individuals with DLG3 mutations

  17. E6AP is extensively involved in the ubiquitin-mediated degradation of Dlg (an HPV E6-dependent substrate) as a cellular E3 ubiquitin-protein ligase.

  18. The results of this study suggested a putative role for DLG3/SAP102 in cortical hyperexcitability and epileptogenicity of malformations of cortical development.

Mouse (Murine) Discs, Large Homolog 3 (Drosophila) (DLG3) Interaktionspartner

  1. Following the critical period NMDA receptor function was unaffected by loss of SAP102 but there was a reduction in the divergence of TC connectivity. These data suggest that changes in synaptic function early in development caused by mutations in SAP102 result in changes in network connectivity later in life.

  2. our current study identified a functional interplay between PSD-95 and synapse-associated protein 102 (SAP102) to regulate synaptic AMPA receptors

  3. SAP102 has a fundamental role in trafficking the NMDA receptor complex to the synaptic sites.

  4. The Dlg3 have functions in complex cognitive processes.

  5. Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin.

  6. Dlg3 exerts a distinct function by recruiting the ubiquitin ligases Nedd4 and Nedd4-2 through its PPxY motifs. These interactions are required for Dlg3 monoubiquitination, apical membrane recruitment, and tight junction consolidation.

  7. Membrane-associated guanylate kinase homolog SAP102 is a central organizers of the postsynaptic density at excitatory synapses on pyramidal neurons.

  8. SAP102 interacts with the PDZ-binding domain of Sec8, a member of the exocyst complex. nteractions between the two proteins are involved in the delivery of N-methyl-D-aspartate receptors to the cell surface in heterologous cells and neurons.

  9. SAP102 was required for normal spatial learning. Loss of SAP102 results in changes in spatial strategy usage. Altered long term potentiation and spike-timing-dependent plasticity in SAP102 mutants. Couples NMDA receptors to MAPK/ERK pathway.

  10. Results describe E-dlg, a mouse homologue of the Drosophila discs large tumor suppressor (Dlg, also known as SAP97), that binds preferentially to SAP102.

  11. SAP102 and PSD-95 regulate the synaptic trafficking of distinct glutamate receptor subtypes at different developmental stages, thereby playing necessary roles in excitatory synapse development.

DLG3 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described.

Genbezeichner und Symbole assoziert mit DLG3

  • discs large MAGUK scaffold protein 3 (DLG3) Antikörper
  • discs, large homolog 3 (Drosophila) (dlg3) Antikörper
  • discs, large homolog 3 (Drosophila) (Dlg3) Antikörper
  • discs large MAGUK scaffold protein 3 (Dlg3) Antikörper
  • Dlgh3 Antikörper
  • fa66c08 Antikörper
  • fa66e02 Antikörper
  • fd02c12 Antikörper
  • fu95c12 Antikörper
  • im:7138640 Antikörper
  • mKIAA1232 Antikörper
  • MPP3 Antikörper
  • MRX Antikörper
  • MRX90 Antikörper
  • NEDLG Antikörper
  • SAP102 Antikörper
  • si:ch211-276g21.1 Antikörper
  • wu:fa66c08 Antikörper
  • wu:fa66e02 Antikörper
  • wu:fd02c12 Antikörper
  • wu:fu95c12 Antikörper
  • XLMR Antikörper

Bezeichner auf Proteinebene für DLG3

disks large homolog 3 , neuroendocrine-DLG , synapse-associated protein 102 , SAP-102 , discs large homolog 3 , discs, large homolog 3 (neuroendocrine-dlg, Drosophila) , membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) , PSD-95/SAP90-related protein 1 , SAP102

GENE ID SPEZIES
1741 Homo sapiens
564081 Danio rerio
53310 Mus musculus
428706 Gallus gallus
491942 Canis lupus familiaris
100516124 Sus scrofa
509882 Bos taurus
58948 Rattus norvegicus
100732206 Cavia porcellus
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