Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) ELISA Kits

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. Zusätzlich bieten wir Ihnen DTL Antikörper (50) und DTL Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Human DTL DTL 51514 Q9NZJ0
Anti-Ratte DTL DTL 305073  
Anti-Maus DTL DTL 76843 Q3TLR7
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Weitere ELISA Kits für DTL Interaktionspartner

Human Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) Interaktionspartner

  1. Findings suggest that DTL (zeige TNFSF13B ELISA Kits) overexpression plays a crucial role in tumor cell proliferation in gastric carcinoma.

  2. CDT2 mediated XPG (zeige ERCC5 ELISA Kits) elimination from DNA damage sites clears the chromatin space needed for repair.

  3. CDT2 likely is a non-oncogene (zeige RAB1A ELISA Kits) to which transformed cells become addicted because of their enhanced cellular stress, such as replicative stress and DNA damage.

  4. These findings reveal C/EBPalpha (zeige CEBPA ELISA Kits) regulates G1/S cell cycle arrest in response to DNA damage via the control of CRL4(Cdt2) mediated degradation of p21 (zeige CDKN1A ELISA Kits).

  5. CDK1 activity blocks CRL4CDT2 by preventing chromatin recruitment of the substrate receptor, CDT2.

  6. while interaction with PCNA (zeige PCNA ELISA Kits) was important for targeting p21 (zeige CDKN1A ELISA Kits) to the CRL4Cdt2 ligase re-localized to MVM replication centers

  7. CRL4(Cdt2)-dependent degradation of TDG (zeige TDG ELISA Kits) occurs in S phase because of the requirement for TDG (zeige TDG ELISA Kits) to interact with chromatin-loaded PCNA (zeige PCNA ELISA Kits), and this degradation is important for preventing toxicity from excess TDG (zeige TDG ELISA Kits).

  8. Data shows that phosphorylation of Cdt2 at T464 is important fot its interaction with Cdt2.

  9. TGF-beta signaling promotes exit from the cell cycle and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.

  10. ubiquitination of p12 through CRL4(Cdt2) and subsequent degradation form one mechanism by which a cell responds to DNA damage to inhibit fork progression.

Mouse (Murine) Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) Interaktionspartner

  1. while interaction with PCNA (zeige PCNA ELISA Kits) was important for targeting p21 to the CRL4Cdt2 ligase re-localized to MVM replication centers

  2. L2dtl gene expression is essential for very early mouse embryonic development

DTL Antigen-Profil

Beschreibung des Gens

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).

Genbezeichner und Symbole assoziert mit DTL

  • denticleless E3 ubiquitin protein ligase homolog (DTL) Antikörper
  • denticleless E3 ubiquitin protein ligase homolog (Dtl) Antikörper
  • denticleless E3 ubiquitin protein ligase (Dtl) Antikörper
  • 2810047L02Rik Antikörper
  • 5730564G15Rik Antikörper
  • CDT2 Antikörper
  • DCAF2 Antikörper
  • L2DTL Antikörper
  • Ramp Antikörper
  • RGD1310439 Antikörper

Bezeichner auf Proteinebene für DTL

DDB1 and CUL4 associated factor 2 , DDB1- and CUL4-associated factor 2 , RA regulated nuclear matrix associated protein , RA-regulated nuclear matrix-associated protein , denticleless homolog , denticleless protein homolog , lethal(2) denticleless protein homolog , retinoic acid-regulated nuclear matrix-associated protein , Meth A ramp , meth A retinoic acid-regulated nuclear matrix-associated protein , retinoic-acid regulated nuclear matrix-associated protein

GENE ID SPEZIES
51514 Homo sapiens
490279 Canis lupus familiaris
539953 Bos taurus
305073 Rattus norvegicus
421373 Gallus gallus
76843 Mus musculus
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