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DEGS1 encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. Zusätzlich bieten wir Ihnen Delta(4)-Desaturase, Sphingolipid 1 Kits (5) und Delta(4)-Desaturase, Sphingolipid 1 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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genetic ablation of DEGS1 in preadipocytes prevented adipogenesis and decreased lipid accumulation. This was associated with elevated oxidative stress, cellular death, and blockage of the cell cycle.
The role of Degs1 in the hypoxic mouse heart.Hand2 and NFATC physically interact on the DEGS1 promoter.
Ablation of dihydroceramide desaturase 1 simultaneously stimulates anabolic and catabolic signaling.
Des1 ablation activated pro-survival and anabolic signaling intermediates (e.g. Akt/PKB (zeige AKT1 Antikörper), mTOR (zeige FRAP1 Antikörper), MAPK (zeige MAPK1 Antikörper), etc.) and provided protection from apoptosis caused by etoposide.
overexpression of DEGS1 or DEGS2 attenuates the DHC accumulation and increased cell proliferation during hypoxia
analysis of dihydroceramide desaturase regulation by palmitate versus monounsaturated fatty acids and its implications for insulin (zeige INS Antikörper) resistance
Data show that CS-mediated SCC (zeige CYP11A1 Antikörper) lethality was mitigated in irradiated gain-of-function Rad50 (zeige RAD50 Antikörper)(s/s) mice, and epistasis studies order Rad50 (zeige RAD50 Antikörper) upstream of Mre11 (zeige MRE11A Antikörper).
GT11 is the first specific inhibitor of dihydroceramide desaturase described so far
DES1 plays a key role in palmitic acid-mediated caspase 9 and caspase 3 (zeige CASP3 Antikörper) activation.
SKI (zeige SKI Antikörper) II is a noncompetitive inhibitor (Ki = 0.3 muM) of Des1 activity with effect also in intact cells without modifying Des1 protein levels. Molecular modeling studies support that the SKI (zeige SKI Antikörper) II-induced decrease in Des1 activity could result from inhibition of NADH-cytochrome b5 reductase (zeige CYB5RL Antikörper).
ABC294640 may reduce the proliferative capacity of castration-resistant prostate cancer cells through inhibition of both sphingosine kinase 2 (zeige SPHK2 Antikörper) and dihydroceramide desaturase.
Dihydroceramide desaturase 1 (DES (zeige DES Antikörper)) is a potential molecular target for regulating apoptotic resistance to photodynamic therapy
changes in lipid homeostasis and gene expression in Huh7 hepatocytes when the synthesis of ceramide is perturbed by knocking down serine pal mitoyltransferase subunits 1, 2, and 3 (SPTLC123) or dihydroceramide desaturase 1 (DEGS1)
a role of the sphingolipid pathway, dihydroceramides desaturase in particular, in confluence-induced growth arrest in neuroblastoma (zeige ARHGEF16 Antikörper) cells
oxidative stress leads to potent inhibition of dihydroceramide desaturase resulting in significant elevation in dihydroceramide levels in vivo
identification of sphingolipid delta 4-desaturase family
partial loss of DEGS-1 inhibited cell growth, with cell cycle arrest at G(0)/G(1). This was accompanied by a significant decrease in the amount of phosphorylated retinoblastoma protein
This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor.
degenerative spermatocyte homolog 1, lipid desaturase
, sphingolipid delta(4)-desaturase DES1
, dihydroceramide desaturase
, degenerative spermatocyte homolog, lipid desaturase
, cell migration-inducing gene 15 protein
, membrane fatty acid (lipid) desaturase
, membrane lipid desaturase
, migration-inducing gene 15 protein
, sphingolipid delta 4 desaturase
, sphingolipid delta(4)-desaturase 1
, degenerative spermatocyte-like protein RDES