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DEFB118 encodes a member of the beta subfamily of defensins.
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DEFB118 may contribute to epididymal innate immunity and provide antimicrobial activity against microorganisms attacking sperm in the male and female reproductive tracts.
This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. Expression of this gene is regulated by androgen, and the encoded protein binds to sperm and exhibits antibacterial activity. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20.
, beta-defensin 118
, defensin, beta 18
, epididymal secretory protein 13.6
, epididymus specific clone 42
, beta defensin 118
, epididymis-specific protein ESP13.6