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Role and function of the EGFR-ERK-MYC axis as a repressor of HBD1 expression and suppression observed in colorectal cancer.
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hBD-1 is prominently expressed in hepatocytes. It is induced during cholestasis through bilirubin and BAs, mediated by CAR and especially FXR. Reduction by TXN activates hBD-1 to a potential key player in innate antimicrobial defense of the liver.
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Being aware of the relatively small sample size and medium power, our results possibly suggest that hBD-1 could influence oocyte and sperm quality, and could improve, when exogenously added, sperm motility.
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DEFB1 -44C/G (rs1800972) is associated with chronic periodontitis in Henan Han population, and the -44CG, GG genotype and G allele may be the protective factors of chronic periodontitis in Henan Han population
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It is a immune component extensively expressed in mucosa and epidermis, which are responsible for the first line of host defense.
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Results provide evidence that DEFB1 is associated with vitiligo. Its polymorphism may modulate vitiligo risk whereas HBD-1 blood levels might be related to its pathogenesis.
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our results suggest beta-defensin 1 plays an important role in protecting HCV progression and liver cancer development.
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Damaging nonsense variants of African ancestry in the DEFB1 and MBL2 genes that encode anti-microbial proteins that presumably defend the fetal membranes from infectious agents confer risk of preterm premature rupture of membranes and preterm birth in African Americans.
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novel DEFB1/hBD-1 properties and biomarker features.
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These results extend the immunoregulatory effects of hBD-1 and provide a potential mechanism for the protective role of hBD-1 in early infants.
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C allele of -44 C/G polymorphism, as well as haplotype AC are associated with the presence of T2DM in the Mexican population.
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The single nucleotide polymorphism in DEFB1 gene is associated with the risk of acute respiratory distress syndrome.
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In this Brazilian population, genetic variations of DEFB1 gene (SNP-20: G allele and GA and GG genotypes) and the DEFB1 5'UTR haplotypes (GCG and ACG) may be associated with a susceptibility to chronic periodontitis in DM2 individuals as well as CP individuals without diabetes mellitus type 2.
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The allelic distribution of the polymorphism rs12355840 in miRNA202 was associated with caries experience in the Brazilian Manaus group. In the Ribeirao Preto group, the allelic and genotypic distributions in the polymorphism rs11362 in DEFB1 were associated with caries experience.
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These studies identified SNPs that were cis-eQTLs for DEFB1 and AHR and, which were associated with variation in plasma KYN concentrations that were related to severity of major depressive disordersymptoms.
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a considerable connection of DEFB1 and TCF7L2 gene polymorphisms with nephrolithiasis
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identification of critical promoter regions of DEFB1 that are epigenetically influenced by lactobacilli in vaginal keratinocytes
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Endometrial tissues and epithelial cells constitutively secreted both BD-1 and -2 mostly at the apical compartment. Both genistein and daidzein induced BDs secretion which reached a peak at 5-15 min. The apical secretion of BDs was coincidence with increased Cl- secretion induced by genistein.
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The polymorphisms in DEFB1 were not associated with hBD salivary level and caries experience (p > 0.05) in children.
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These findings suggest a role for hBD-1 in psoriasis pathogenesis