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The protein encoded by DBR1 is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. Zusätzlich bieten wir Ihnen DBR1 Antikörper (24) und DBR1 Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.
findings support a new view of the early steps in HIV genome replication - they support a model in which lariat formation of viral genomic RNA is important for minus-strand transfer, with DBR1 being required to resolve the lariat to allow reverse transcription to proceed
saturation mutagenesis of DBR1 and Gal4 (zeige LGALS4 ELISA Kits) and show that the experimental phenotypes for over 80% of the mutations correlate well with predicted effects of mutations on protein stability and RNA binding affinity.
Results of protein-protein interaction between human Dbr1 and factors found in the Intron Large complex identify Xab2 (zeige XAB2 ELISA Kits) and a novel protein CWF19L1 as specific interactors of DBR1.
Inhibition of DBR1 caused a significant reduction in the formation of intermediate and full-length HIV-1 cDNA.
Dbr1 protein cleaves the 2'-5' phosphodiester bond of intron lariats, necessary for subsequent intron degradation that follows pre-mRNA splicing.
Lariat RNAs localized in nuclear bodies, and partially co-localize with HYL1 (zeige EPHX1 ELISA Kits), and both DCL1 (zeige CD302 ELISA Kits) and HYL1 (zeige EPHX1 ELISA Kits) were mis (zeige AMH ELISA Kits)-localized in dbr1-2... we thus propose that lariat RNAs, as decoys, inhibit miRNA processing, suggesting a hitherto unknown layer of regulation in miRNA biogenesis.
The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication.
lariat debranching enzyme
, debranching enzyme homolog 1 (S. cerevisiae)
, lariat debranching enzyme-like
, RNA lariat debranching enzyme
, debranching enzyme homolog 1